Zobrazeno 1 - 10 of 1 012 pro vyhledávání: '"5.2 Cellular and gene therapies"'
1
Recent advances in stem cell therapy for erectile dysfunction: a narrative review
Autor: Wang, Bohan, Gao, Wenjun, Zheng, Micha Y, Lin, Guiting, Lue, Tom F
Publikováno v: Expert opinion on biological therapy, vol 23, iss 6
IntroductionWhile phosphodiesterase type 5 inhibitors (PDE5is) and others are used to treat Erectile dysfunction (ED), many patients are either unresponsive or resistant to it. Stem cell therapy (SCT) is a promising alternative approach. Numerous pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2354e6d216e3721e716d7d109b2b420
https://doi.org/10.1080/14712598.2023.2203811
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2
In Vitro Generated Equine Hepatic-Like Progenitor Cells as a Novel Potent Cell Pool for Equine Metabolic Syndrome (EMS) Treatment
Autor: Krzysztof Marycz, Nabila Bourebaba, Anna Serwotka-Suszczak, Malwina Mularczyk, Larry Galuppo, Lynda Bourebaba
Publikováno v: Stem cell reviews and reports, vol 19, iss 4
Equine metabolic syndrome (EMS) is recognized as one of the leading cause of health threatening in veterinary medicine worldwide. Recently, PTP1B inhibition has been proposed as an interesting strategy for liver insulin resistance reversion in both e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde78f1c8f327c640dbdc519476a32c5
https://doi.org/10.1007/s12015-023-10507-3
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3
Hypophosphatemia Due to Increased Effector Cell Metabolic Activity Is Associated with Neurotoxicity Symptoms in CD19-Targeted CAR T-cell Therapy
Autor: Jack Pengfei Tang, Cole W. Peters, Crystal Quiros, Xiaoyan Wang, Alexandra M. Klomhaus, Reiko E. Yamada, John M. Timmerman, Theodore B. Moore, Theodore S. Nowicki
Publikováno v: Cancer immunology research, vol 10, iss 12
Cancer Immunol Res
A major complication of chimeric antigen receptor (CAR) T-cell therapy is immune effector cell–associated neurotoxicity syndrome (ICANS), which presents as aphasia, confusion, weakness, somnolence, seizures, and coma. This is similar to the neurolo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0f8f770d6b22bd92fe70d4e1f67a66
https://doi.org/10.1158/2326-6066.cir-22-0418
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4
Fluidic Device System for Mechanical Processing and Filtering of Human Lipoaspirate Enhances Recovery of Mesenchymal Stem Cells
Autor: Jeremy A. Lombardo, Derek A. Banyard, Alan D. Widgerow, Jered B. Haun
Publikováno v: Plast Reconstr Surg
Plastic and reconstructive surgery, vol 151, iss 1
BackgroundAdipose tissue is an easily accessible source of stem and progenitor cells that offers exciting promise as an injectable autologous therapeutic for regenerative applications. Mechanical processing is preferred over enzymatic digestion, and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc15651cac7376dfba8312dfe79ffe42
https://doi.org/10.1097/prs.0000000000009798
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6
Recent Advances in Site-Specific Lipid Nanoparticles for mRNA Delivery
Autor: Xiao Xu, Tian Xia
Publikováno v: ACS nanoscience Au, vol 3, iss 3
The success of mRNA vaccines during the COVID-19 pandemic has greatly accelerated the development of mRNA therapy. mRNA is a negatively charged nucleic acid that serves as a template for protein synthesis in the ribosome. Despite its utility, the ins
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971e3061dacd2c1f9bbb098db61d85dc
https://escholarship.org/uc/item/648009tv
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7
Regulation of neural stem cell differentiation and brain development by MGAT5-mediated N-glycosylation
Autor: Andrew R. Yale, Estelle Kim, Brenda Gutierrez, J. Nicole Hanamoto, Nicole S. Lav, Jamison L. Nourse, Marc Salvatus, Robert F. Hunt, Edwin S. Monuki, Lisa A. Flanagan
Publikováno v: Stem cell reports, vol 18, iss 6
Undifferentiated neural stem and progenitor cells (NSPCs) encounter extracellular signals that bind plasma membrane proteins and influence differentiation. Membrane proteins are regulated by N-linked glycosylation, making it possible that glycosylati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c07f02debd0939146de0b07e3c4100e
https://escholarship.org/uc/item/0v46398t
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8
High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails
Autor: Brian R. Shy, Vivasvan S. Vykunta, Alvin Ha, Alexis Talbot, Theodore L. Roth, David N. Nguyen, Wolfgang G. Pfeifer, Yan Yi Chen, Franziska Blaeschke, Eric Shifrut, Shane Vedova, Murad R. Mamedov, Jing-Yi Jing Chung, Hong Li, Ruby Yu, David Wu, Jeffrey Wolf, Thomas G. Martin, Carlos E. Castro, Lumeng Ye, Jonathan H. Esensten, Justin Eyquem, Alexander Marson
Publikováno v: Nat Biotechnol
Nature biotechnology, vol 41, iss 4
Enhancing CRISPR-mediated site-specific transgene insertion efficiency by homology-directed repair (HDR) using high concentrations of double-stranded DNA (dsDNA) with Cas9 target sequences (CTSs) can be toxic to primary cells. Here, we develop single
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6abc27058fcb320900fce44e32d76f
https://doi.org/10.1038/s41587-022-01418-8
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9
Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma
Autor: Jaehoon Shin, Matthew F. L. Parker, Iowis Zhu, Aryn Alanizi, Carlos I. Rodriguez, Raymond Liu, Payal B. Watchmaker, Mausam Kalita, Joseph Blecha, Justin Luu, Brian Wright, Suzanne E. Lapi, Robert R. Flavell, Hideho Okada, Thea D. Tlsty, Kole T. Roybal, David M. Wilson
Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol 64, iss 1
For the past several decades, chimeric antigen receptor T cell (CAR T) therapies have shown promise in the treatment of cancers. These treatments would greatly benefit from companion imaging biomarkers to follow the trafficking of T cells in vivo. Us
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802e364c992d32156f510ca36ba5715a
https://doi.org/10.2967/jnumed.122.264284
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10
Epigenetic Regulation of NGF-Mediated Osteogenic Differentiation in Human Dental Mesenchymal Stem Cells
Autor: Zhenqing Liu, Jin Sook Suh, Peng Deng, Olga Bezouglaia, Megan Do, Mojan Mirnia, Zhong-Kai Cui, Min Lee, Tara Aghaloo, Cun-Yu Wang, Christine Hong
Publikováno v: Stem cells (Dayton, Ohio), vol 40, iss 9
Stem Cells
Nerve growth factor (NGF) is the best-characterized neurotrophin and is primarily recognized for its key role in the embryonic development of the nervous system and neuronal cell survival/differentiation. Recently, unexpected actions of NGF in bone r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9a10b5bb05a07819994225589739f3
https://doi.org/10.1093/stmcls/sxac042
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