Zobrazeno 1 - 10
of 335
pro vyhledávání: '"5-fu resistance"'
Autor:
Rong Xu, Ashuai Du, Xinpei Deng, Wei Du, Kaiying Zhang, Jianbo Li, Yingxue Lu, Xiaoli Wei, Qinglong Yang, Hailin Tang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Background tRNA-derived small RNAs (tsRNAs) are newly discovered non-coding RNA, which are generated from tRNAs and are reported to participate in several biological processes in diseases, especially cancer; however, the mechanism of tsRNA i
Externí odkaz:
https://doaj.org/article/75d41d7449714cf7a822002e9d2bb575
Autor:
Ran Duan, Yujia Zhai, Qiushuang Wang, Liqin Zhao, Yixuan Wang, Nuoya Yu, Jieyun Zhang, Weijian Guo
Publikováno v:
MedComm, Vol 5, Iss 11, Pp n/a-n/a (2024)
Abstract Few biomarkers are available for predicting chemotherapeutic response and prognosis in colorectal cancer (CRC). Long‐noncoding RNAs (lncRNAs) are essential for CRC development and growth. Therefore, studying lncRNAs may reveal potential pr
Externí odkaz:
https://doaj.org/article/cd22939b6b8c41279d9959c6ee3f1f2a
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 1, Pp 121-139 (2023)
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and is responsible for approximately one million deaths each year. The current standard of care is surgical resection of the lesion and chemotherapy with 5-fluorouracil (5-FU). How
Externí odkaz:
https://doaj.org/article/be72817f4e7d4914ab7c80ab267701d0
Autor:
Yu Zheng, Jiansheng Wu, Hong Chen, Dajia Lin, Hongyuan Chen, Junyin Zheng, Haoyun Xia, Liangxiang Huang, Changqing Zeng
Publikováno v:
Cancer Biology & Therapy, Vol 24, Iss 1 (2023)
Background Accumulating studies demonstrated that resistance of colon cancer (CC) to 5-fluorouracil (5-FU) contributes to adverse prognosis. We investigated how Kruppel-like factor 4 (KLF4) affected 5-FU resistance and autophagy in CC cells. Methods
Externí odkaz:
https://doaj.org/article/5f48e6e1cf744020897b2c34005f27b9
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-16 (2022)
Abstract Background Gastric cancer (GC) is a commonly occurring human malignancy. The 5-fluorouracil (5-Fu) is a first-line anti-gastric cancer agent. However, a large number of GC patients developed 5-Fu resistance. Currently, the roles and molecula
Externí odkaz:
https://doaj.org/article/06e381ab614242378211cb70b353943d
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Janusz Matuszyk
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-33 (2022)
Abstract Background The active metabolite of 5-Fluorouracil (5FU), used in the treatment of several types of cancer, acts by inhibiting the thymidylate synthase encoded by the TYMS gene, which catalyzes the rate-limiting step in DNA replication. The
Externí odkaz:
https://doaj.org/article/0c7a6cd5c5a9400ab2d7395821708cce
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Resistance to 5-fluorouracil (5-FU) in chemotherapy and recurrence of colorectal tumors is a serious concern that impedes improvements to clinical outcomes. In the present study, we found that conditioned medium (CM) derived from 5-FU-resist
Externí odkaz:
https://doaj.org/article/80eca240813a41b9a34ae29888ba42f5
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and one of the major causes of cancer-related death. Thymidylate synthase (TYMS) catalyzes the methylation of deoxy guanosine to deoxy thymidylate, whi
Externí odkaz:
https://doaj.org/article/b07bd7bb46f149da9801557b78257232