Výsledky vyhledávání - "5-Iodouracil"

Akademický článek

Synthesis of N-Substituted 5-Iodouracils as Antimicrobial and Anticancer Agents

Autor: Virapong Prachayasittikul, Somsak Ruchirawat, Apilak Worachartcheewan, Ratchanok Pingaew, Nirun Sornsongkhram, Supaluk Prachayasittikul

Publikováno v: Molecules, Vol 14, Iss 8, Pp 2768-2779 (2009)

This study reports the synthesis of some substituted 5-iodouracils and their bioactivities. Alkylation of 5-iodouracils gave predominately N1-substituted-(R)-5-iodouracil compounds 7a-d (R = n-C4H9, s-C4H9, CH2C6H11, CH2C6H5) together with N1,N3-disu

Externí odkaz: https://doaj.org/article/8ea26a84de174b0d82770b102a6d1313

Zobrazit plný text záznamu

Direct Arylation of 5-Iodouracil and 5-Iodouridine with Heteroarenes and BenzeneviaPhotochemical Reaction

Autor: Yun He, Qian Yang, Yong Liang, Zunting Zhang, Tao Wei

Publikováno v: Helvetica Chimica Acta. 98:953-960

A method for the direct arylation of 5-iodouracil and 5-iodouridine was found to proceed in moderate yields. By irradiating mixtures of 5-iodouracil or 5-iodouridine and a series of five-membered heterocycles such as 1H-pyrrole, furan, 2-methylfuran,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0579063fe02c155c41298c410a527a93
https://doi.org/10.1002/hlca.201400351

Zobrazit plný text záznamu

Evaluation of 1-(2-deoxy-2-fluoro-1-d-arabinofuranosyl)-5-iodouracil (FIAU) as an ex vivo bacterial detection agent

Autor: David Tung, Decrescenzo Gary A, Dean Welsch, Peter H. Cheung, Chetan Bettegowda, Saurabh Saha

Publikováno v: World Journal of Microbiology and Biotechnology. 30:3003-3010

The nucleoside analogue, 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU) is a substrate for thymidine kinase (TK), which is commonly expressed in bacteria. It is currently being investigated in clinical studies as an in vivo bacterial i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912333670f567ede2c4a783d2f5bfc16
https://doi.org/10.1007/s11274-014-1709-x

Zobrazit plný text záznamu

Metal Complexes of Uracil Derivatives with Cytotoxicity and Superoxide Scavenging Activity

Autor: Apilak Worachartcheewan, Somsak Ruchirawat, Supaluk Prachayasittikul, Chartchalerm Isarankura-Na-Ayudhya, Virapong Prachayasittikul, Ratchanok Pingaew, Thummaruk Suksrichavalit

Publikováno v: Letters in Drug Design & Discovery. 9:282-287

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d5939eb6f5daf557baf8712ab554165
https://doi.org/10.2174/157018012799129918

Zobrazit plný text záznamu

Effects of structural differences between radioiodine-labeled 1-(2′-fluoro-2′-deoxy-d-arabinofuranosyl)-5-iodouracil (FIAU) and 1-(2′-fluoro-2′-deoxy-d-ribofuranosyl)-5-iodouracil (FIRU) on HSV1-TK reporter gene imaging

Autor: Su Hee Hong, Sang Moo Lim, Tae Hyun Choi, Chang Woon Choi, Eun Ah Lee, Kyeong Min Kim, Mohammed I. El-Gamal, Eun-Jung Kim, Kyo Chul Lee, Gwang Il An, Gi Jeong Cheon

Publikováno v: Applied Radiation and Isotopes. 68:971-978

The goal of this investigation was to evaluate the effects of structural differences between FIAU and FIRU on their ability to serve as a potential tracer for reporter gene imaging. To examine the characteristics of different configurations of FIAU a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b373cb4a94ed424057ee14aa5f7bae6
https://doi.org/10.1016/j.apradiso.2009.12.032

Zobrazit plný text záznamu

Structures of native human thymidine phosphorylase and in complex with 5-iodouracil

Autor: K. R. Acharya, Anastassios C. Papageorgiou, Stephen H. Prior, Darrell Sleep, E Mitsiki, Nethaji Thiyagarajan, Shalini Iyer, C Finnis

Publikováno v: Biochemical and Biophysical Research Communications

Thymidine phosphorylase (TP) first identified as platelet derived endothelial cell growth factor (PD-ECGF) plays a key role in nucleoside metabolism. Human TP (hTP) is implicated in angiogenesis and is overexpressed in several solid tumors. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc653531b89fd2d5da2224c691d8842
https://doi.org/10.1016/j.bbrc.2009.06.104

Zobrazit plný text záznamu

Synthesis of N-Substituted 5-Iodouracils as Antimicrobial and Anticancer Agents

Autor: Nirun Sornsongkhram, Apilak Worachartcheewan, Somsak Ruchirawat, Supaluk Prachayasittikul, Virapong Prachayasittikul, Ratchanok Pingaew

Publikováno v: Molecules, Vol 14, Iss 8, Pp 2768-2779 (2009)
Molecules
Volume 14
Issue 8
Pages 2768-2779

This study reports the synthesis of some substituted 5-iodouracils and their bioactivities. Alkylation of 5-iodouracils gave predominately N1-substituted-(R)-5-iodouracil compounds 7a-d (R = n-C(4)H(9), s-C(4)H(9), CH(2)C(6)H(11), CH(2)C(6)H(5)) toge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142a1232d03af800d924740564c39d1f
http://www.mdpi.com/1420-3049/14/8/2768/

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání