Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT1A receptor partial agonism and α1-adrenoceptor antagonism.

Autor: Montalbano, Alberto¹, Mlinar, Boris¹, Bonfiglio, Francesco¹, Polenzani, Lorenzo², Magnani, Maurizio², Corradetti, Renato¹ renato.corradetti@unifi.it

Publikováno v: PLoS ONE. 9/26/2019, Vol. 14 Issue 9, p1-19. 19p.

Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT1A receptor partial agonism and α1-adrenoceptor antagonism.

Autor: Alberto Montalbano, Boris Mlinar, Francesco Bonfiglio, Lorenzo Polenzani, Maurizio Magnani, Renato Corradetti

Publikováno v: PLoS ONE, Vol 14, Iss 9, p e0222855 (2019)

Trazodone is an antidepressant drug with considerable affinity for 5-HT1A receptors and α1-adrenoceptors for which the drug is competitive agonist and antagonist, respectively. In this study, we used cell-attached or whole-cell patch-clamp recording

Externí odkaz: https://doaj.org/article/07ef699a206b4b5dafefeb5073ffa4b4

Interaction of Dopamine D2 and 5-HT1A Receptor Partial Agonism on Antipsychotic Efficacy.

Autor: Lloyd H; Antipsychotic Research Laboratory, Illawarra Health and Medical Research Institute, Wollongong, New South Wales, AustraliaSchool of Medicine, University of Wollongong, Wollongong, New South Wales, AustraliaIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong, New South Wales, Australia chao@uow.edu.auSchool of Medicine, University of Wollongong, Wollongong, New South Wales, Australia., Deng C

Publikováno v: Journal of clinical psychopharmacology [J Clin Psychopharmacol] 2016 Apr; Vol. 36 (2), pp. 192-3.

HTR1A gene polymorphisms and 5-HT1A receptor partial agonist antipsychotics efficacy in Schizophrenia

Autor: Naotaka Sunada, Yosuke Koshikawa, Yoshiteru Takekita, Masaki Kato, Shinpei Nonen, Chiara Fabbri, Toshihiko Kinoshita, Gaku Okugawa, Masataka Wakeno, Shiho Sakai, Alessandro Serretti

Individual differences in serotonin 1A (5-HT1A) receptor may result in variable response to antipsychotics with 5-HT1A receptor partial agonism. We investigated the relationship between 5-HT1A receptor gene (HTR1A) single nucleotide polymorphisms (SN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c755043b0e6d8dc01446b8e0512e8bb
http://hdl.handle.net/11585/542912

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