Zobrazeno 1 - 10
of 105
pro vyhledávání: '"5-Diphosphate"'
Autor:
Zhiqiang Chen, Xinyi Zhou, Xiaojun Zhou, Yi Tang, Mingzhu Lu, Jianhong Zhao, Chenhui Tian, Mingzhi Wu, Yanliang Liu, Edward V. Prochownik, Fubing Wang, Youjun Li
Publikováno v:
Advanced Science, Vol 10, Iss 12, Pp n/a-n/a (2023)
Abstract β‐catenin signaling is abnormally activated in cancer. Here, this work screens the mevalonate metabolic pathway enzyme PMVK to stabilize β‐catenin signaling using a human genome‐wide library. On the one hand, PMVK‐produced MVA‐5P
Externí odkaz:
https://doaj.org/article/0597d71d8ea24677a6a0c5db2e8da9dd
Autor:
Voelker, Taylor L, Del Villar, Silvia G, Westhoff, Maartje, Costa, Alexandre D, Coleman, Andrea M, Hell, Johannes W, Horne, Mary C, Dickson, Eamonn J, Dixon, Rose E
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 14
CaV1.2 channels are critical players in cardiac excitation-contraction coupling, yet we do not understand how they are affected by an important therapeutic target of heart failure drugs and regulator of blood pressure, angiotensin II. Signaling throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::23325339dd525c7cad9b280fe4caed32
https://escholarship.org/uc/item/9cz4g77z
https://escholarship.org/uc/item/9cz4g77z
Akademický článek
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Autor:
Vedbar S. Khadka, F. David Horgen, Sharon Rozovsky, Peter R. Hoffmann, Greg S. Gojanovich, Michael P. Marciel, Ellis N.L. Akana, Chi Ma, Melodie A. Williams-Aduja, Mariana Gerschenson, Johann Urschitz, FuKun W. Hoffmann, Stefan Moisyadi, Kathleen E. Page, Youping Deng
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 47, Iss, Pp 101170-(2021)
Molecular Metabolism, Vol 47, Iss, Pp 101170-(2021)
Objective T cell activation triggers metabolic reprogramming to meet increased demands for energy and metabolites required for cellular proliferation. Ethanolamine phospholipid synthesis has emerged as a regulator of metabolic shifts in stem cells an
Autor:
Ronald M. Krauss, Ba-Bie Teng, Yuanyuan Qin, Rosanne M. Crooke, Andréa C. Dosé, Zemin Yao, Jacob Strelnikov, Mohsen Amir Alipour, Marisa W. Medina, Mee J. Kim, Joseph Harmon, Feng Gao, Flora Ting
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology, vol 40, iss 5
Arterioscler Thromb Vasc Biol
Arterioscler Thromb Vasc Biol
Objective: TMEM55B (transmembrane protein 55B) is a phosphatidylinositol-(4,5)-bisphosphate (PI[4,5]P 2 ) phosphatase that regulates cellular cholesterol, modulates LDLR (low-density lipoprotein receptor) decay, and lysosome function. We tested the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b00aa74b4d5405c9ef9f2cd1ff80a3a
https://escholarship.org/uc/item/3jh2c75s
https://escholarship.org/uc/item/3jh2c75s
Autor:
Amrita Samanta, Aysenur Yazici, Taylor E. T. Hughes, Vincenzo Carnevale, Tibor Rohacs, Edwin C. Fluck, Z. Hong Zhou, Kevin W. Huynh, Marina A. Kasimova, Ruth A. Pumroy, Vera Y. Moiseenkova-Bell, Sudheer K. Molugu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature communications, vol 9, iss 1
Nature Communications
Nature communications, vol 9, iss 1
Nature Communications
TRPV5 is a transient receptor potential channel involved in calcium reabsorption. Here we investigate the interaction of two endogenous modulators with TRPV5. Both phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and calmodulin (CaM) have been shown
Autor:
Richard T. Wyatt, Christopher Lim, Rajendra Singh, Charlotte A. Stoneham, Joel O. Wertheim, John C. Guatelli, Xiaofei Jia, Javier Guenaga, Yong Xiong
Publikováno v:
Journal of Biological Chemistry
The Journal of biological chemistry, vol 293, iss 40
The Journal of biological chemistry, vol 293, iss 40
Protein trafficking in the endosomal system involves the recognition of specific signals within the cytoplasmic domains (CDs) of transmembrane proteins by clathrin adaptors. One such signal is the phosphoserine acidic cluster (PSAC), the prototype of
Autor:
Bree K. Grillo-Hill, André Schönichen, Bradley A. Webb, Changhoon Choi, Katharine A. White, Diane L. Barber
Publikováno v:
The Journal of biological chemistry, vol 291, iss 46
The Na-H exchanger NHE1 contributes to intracellular pH (pHi) homeostasis in normal cells and the constitutively increased pHi in cancer. NHE1 activity is allosterically regulated by intracellular protons, with greater activity at lower pHi. However,
Autor:
Martinez Marshall, Maria Nieves, Emmerstorfer-Augustin, Anita, Leskoske, Kristin L, Zhang, Lydia H, Li, Biyun, Thorner, Jeremy
Publikováno v:
Molecular biology of the cell, vol 30, iss 12
Martinez Marshall, Maria Nieves; Emmerstorfer-Augustin, Anita; Leskoske, Kristin L; Zhang, Lydia H; Li, Biyun; & Thorner, Jeremy. (2019). Analysis of the roles of phosphatidylinositol-4,5-bisphosphate and individual subunits in assembly, localization and function of Saccharomyces cerevisiae Target of Rapamycin Complex 2.. Molecular biology of the cell, mbcE18100682. doi: 10.1091/mbc.e18-10-0682. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/97z8s7hr
Martinez Marshall, Maria Nieves; Emmerstorfer-Augustin, Anita; Leskoske, Kristin L; Zhang, Lydia H; Li, Biyun; & Thorner, Jeremy. (2019). Analysis of the roles of phosphatidylinositol-4,5-bisphosphate and individual subunits in assembly, localization and function of Saccharomyces cerevisiae Target of Rapamycin Complex 2.. Molecular biology of the cell, mbcE18100682. doi: 10.1091/mbc.e18-10-0682. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/97z8s7hr
Eukaryotic cell survival requires maintenance of plasma membrane (PM) homeostasis in response to environmental insults and changes in lipid metabolism. In yeast, a key regulator of PM homeostasis is Target of Rapamycin (TOR) complex 2 (TORC2), a mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fc2ffdf4770baee2e357fe21830788cd
https://escholarship.org/uc/item/97z8s7hr
https://escholarship.org/uc/item/97z8s7hr
Autor:
Meng-Ling Shih, John A. Morgan
Publikováno v:
Metabolic Engineering Communications, Vol 10, Iss, Pp e00123-(2020)
Metabolic Engineering Communications
Metabolic Engineering Communications
Numerous secondary metabolites from plants are important for their medicinal, nutraceutical or sensory properties. Recently, significant progress has been made in the identification of the genes and enzymes of plant secondary metabolic pathways. Henc