Výsledky vyhledávání - "5′-monophosphate"

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Causal relationship between plasma metabolites and carpal tunnel syndrome risk: evidence from a mendelian randomization study

Autor: Wenbao Wu, Daofeng Fan, Chong Zheng, Binfu Que, Qing qing Lian, Yangui Chen, Rui Qiu

Publikováno v: Frontiers in Molecular Biosciences, Vol 11 (2024)

BackgroundCarpal tunnel syndrome (CTS) is a common symptom of nerve compression and a leading cause of pain and hand dysfunction. However, the underlying biological mechanisms are not fully understood. The aim of this study was to reveal the causal e

Externí odkaz: https://doaj.org/article/3803f7f231124a07ba316b6ddb9ab183

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An electrochemical adsorption-catalysis sensor based on 2D MXene/g-C3N4 doped with Au-COOH for selective detection of GMP in meat

Autor: Shi, Yingkun ^a, Niu, Zijun ^a, Rodas-Gonzalez, Argenis ^b, Wang, Songlei ^{a, ⁎}, Wang, Yihua ^a, Yang, Lingfan ^a

Publikováno v: In Chemical Engineering Journal 15 November 2024 500

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Unlocking the potential of CMP synthesis: Merging enzyme design, host genome editing, and fermentation optimization strategy

Autor: Qing, Zhou-Lei ^a, Sun, Chuan-Qi ^a, Li, Zong-Lin ^{a, ⁎}, Li, Zhi-Min ^{a, b, ⁎⁎}

Publikováno v: In Process Biochemistry February 2025 149:204-212

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5′-UMP inhibited muscle atrophy due to detraining: a randomized, double-blinded, placebo-controlled, parallel-group comparative study

Autor: Mika Inoue, Atsushi Kubota, Yuji Takazawa, Kosuke Nakagawara, Kazuya Ishige, Yoshio Suzuki

Publikováno v: Frontiers in Sports and Active Living, Vol 6 (2024)

PurposeA short period of disuse of 1–2 weeks due to factors such as illness or injury can lead to muscle atrophy, affecting both athletic performance and health. Recent research has shown that uridine 5′-monophosphate (5′-UMP) can counteract di

Externí odkaz: https://doaj.org/article/49db9082987942a49ecc281e5c17e93a

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Effects of UBE3A on the insulin resistance in polycystic ovary syndrome through the ubiquitination of AMPK

Autor: Ning Ma, Jing Zhou, Zhi Zhou, Bangbei Wan, Weiying Lu

Publikováno v: BMC Endocrine Disorders, Vol 23, Iss 1, Pp 1-10 (2023)

Abstract Background Polycystic ovary syndrome (PCOS) is a reproductive hormonal abnormality and a metabolic disorder, which is frequently associated with insulin resistance (IR). We aim to investigate the potential therapeutic effects of Ubiquitin-pr

Externí odkaz: https://doaj.org/article/bdd511568f234055b40764b367a1c531

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Improving the Phosphatase-Catalyzed Synthesis of 5′-Nucleotides: A Reaction Engineering Approach

Autor: Marina S. Robescu, Teodora Bavaro, Fabrizio Medici, Giovanna Speranza, Daniela Ubiali, Marco Rabuffetti

Publikováno v: Applied Sciences, Vol 14, Iss 14, p 6227 (2024)

5′-Phosphorylation of nucleosides is a reaction as important in nature and in industry as it is cumbersome to be performed. Whilst chemical phosphorylation relies on the use of harsh reagents, solvents, and conditions, as well as on the need for pr

Externí odkaz: https://doaj.org/article/5d93e64059444213a9750ddce09128ef

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Inhibition of SARS–CoV–2 NSP–15 by Uridine–5′–Monophosphate Analogues Using QSAR Modelling, Molecular Dynamics Simulations, and Free Energy Landscape

Autor: Mohammed Merae Alshahrani

Publikováno v: Saudi Pharmaceutical Journal, Vol 32, Iss 1, Pp 101914- (2024)

SARS–CoV–2 is accountable for severe social and economic disruption around the world causing COVID–19. Non–structural protein–15 (NSP15) possesses a domain that is vital to the viral life cycle and is known as uridylate–specific endoribon

Externí odkaz: https://doaj.org/article/02b32ea57423487488d3bd5ea2bfe3a0

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5′-CMP and 5′-UMP alleviate dexamethasone-induced muscular atrophy in C2C12 myotubes

Autor: Kosuke Nakagawara, Chieri Takeuchi, Kazuya Ishige

Publikováno v: Biochemistry and Biophysics Reports, Vol 34, Iss , Pp 101460- (2023)

Atrogin-1 and muscle RING finger 1 (MuRF1) are ubiquitin ligases specifically expressed during skeletal muscle atrophy and mediate muscle protein degradation. In contrast, PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1α), which

Externí odkaz: https://doaj.org/article/ea0a45a0ce664be983445bb904408db3

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Synthesis and Preliminary Evaluation of an ASGPr-Targeted Polycationic β-Cyclodextrin Carrier for Nucleosides and Nucleotides

Autor: Jang-Ha Ryu, Weizhong Zheng, Xiao-Hong Yang, Hassan Elsaidi, Jim Diakur, Leonard I. Wiebe

Publikováno v: Pharmaceutics, Vol 16, Iss 3, p 323 (2024)

Most antiviral and anticancer nucleosides are prodrugs that require stepwise phosphorylation to their triphosphate nucleotide form for biological activity. Monophosphorylation may be rate-limiting, and the nucleotides may be unstable and poorly inter

Externí odkaz: https://doaj.org/article/4b6943cd81af4df299dfbf4056fbdc1b

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