Výsledky vyhledávání - "4-d]pyrimidine"

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Synthesis of fused heterocycles from 2-aryl-5-(chlorosulfonyl)-1,3-oxazole-4-carboxylates and α-aminoazoles involving the Smiles rearrangement

Autor: Maryna Kachaeva, Stepan Pilyo, Sergiy Popilnichenko, Andrii Kornienko, Eduard Rusanov, Volodymyr Prokopenko, Vladimir Zyabrev, Volodymyr S. Brovarets

Publikováno v: Current Chemistry Letters, Vol 7, Iss 4, Pp 101-110 (2018)

Reaction of methyl 2-aryl-5-(chlorosulfonyl)-1,3-oxazole-4-carboxylates with 1H-pyrazol-5-amines and 1H-1,2,4-triazol-5-amines proceeds with the participation of endocyclic aminoazole nitrogen atoms to yield products containing a primary amino group.

Externí odkaz: https://doaj.org/article/0c7caff22a474872ba7bdfd3aa659e10

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Preconcentration and Determination of Lead for Trace Levels in Water and Wastewater Samples by Vortex-Assisted Microextraction Using TPAS as a New Synthetic Complexing Agent with Electrothermal Atomic Absorption Spectroscopy Detection

Autor: Hassanali Moradi, Hossein Eshghi, Mahmoud Chamsaz, Abolfazl Darroudi, Fatemeh Dousti, Issa Zakeri Mofrad

Publikováno v: Iranian Journal of Chemistry & Chemical Engineering, Vol 36, Iss 3, Pp 97-106 (2017)

A simple and rapid solidified vortex assisted 1-undecanol based liquid-liquid microextraction technique was proposed for preconcentration of trace levels of lead ions. The extraction solvent (1-undecanol) was dispersed into the aqueous samples by the

Externí odkaz: https://doaj.org/article/bb1612fb23af492796110723c44ca682

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A PYRAZOLO[3,4-d]PYRIMIDINE COMPOUND REDUCES CELL VIABILITY AND INDUCES APOPTOSIS IN DIFFERENT HEMATOLOGICAL MALIGNANCIES

Autor: Ilaria Laurenzana, Antonella Caivano, Francesco La Rocca, Stefania Trino, Luciana De Luca, Francesca D'Alessio, Silvia Schenone, Geppino Falco, Maurizio Botta, Luigi Del Vecchio, Pellegrino Musto

Publikováno v: Frontiers in Pharmacology, Vol 7 (2016)

Molecular targeted therapies are based upon drugs acting on tumors by interfering with specific targets involved in growth and spread of cancer. Many targeted therapies were approved by Food and Drug Administration as standard treatment, others were

Externí odkaz: https://doaj.org/article/626a72154ca342d08cd52f8c8fcfe89b

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Akademický článek

Synthesis and Antimicrobial Activity of Some New Pyrazole, Fused Pyrazolo[3,4-d]-pyrimidine and Pyrazolo[4,3-e][1,2,4]- triazolo[1,5-c]pyrimidine Derivatives

Autor: Omar A. Miqdad, Nadia G. Kandile, Hamdi M. Hassaneen, Nada M. Abunada

Publikováno v: Molecules, Vol 13, Iss 7, Pp 1501-1517 (2008)

Hydrazonyl bromides 2a,b reacted with active methylene compounds (dibenzoylmethane, acetylacetone, ethyl acetoacetate, phenacyl cyanide, acetoacetanilide, ethyl cyanoacetate, cyanoacetamide and malononitrile) to afford the corresponding 1,3,4,5- tetr

Externí odkaz: https://doaj.org/article/b45b488de1ad4bb591d8414348550f47

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Akademický článek

Synthesis of some pyrazolo[3,4-d]pyrimidines and their fused triazole and tetrazole derivatives

Autor: MAGDI E. A. ZAKI, OSAMA I. ABD EL-SALAM, SAMIRA A. SWELAM

Publikováno v: Journal of the Serbian Chemical Society, Vol 64, Iss 11, Pp 655-662 (1999)

Reaction of 2 with different reagents, namely formic acid, acetic anhydride and trichloroacetonitrile, yielded pyrazolo[3,4-d]pyrimidine derivatives 3, 5 and 6, respectively. Pyrazolo[3,4-d]pyrimidine m-thiazine(7) and 2,4-(1H,3H)dithione (8) derivat

Externí odkaz: https://doaj.org/article/7b33e27aeb3943cda051ba09fa8ac0f8

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Pyrazole[3,4-d]pyrimidine derivatives loaded into halloysite as potential CDK inhibitors

Autor: Aldo Di Leonardo, Patrizia Cancemi, Silvia Schenone, Marina Massaro, Fabrizio Lo Celso, César Viseras Iborra, Serena Riela, Giancarlo Grossi, Viviana Barra, Giampaolo Barone

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Uncontrolled cell proliferation is a hallmark of cancer as a result of rapid and deregulated progression through the cell cycle. The inhibition of cyclin-dependent kinases (CDKs) activities is a promising therapeutic strategy to block cell cycle of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7107a32ddffa4a0ed3fa1da454d34bea
http://hdl.handle.net/10261/276435

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PRECLINICAL CHARACTERIZATION OF SFK INHIBITORS, PYRAZOLO[3,4-d]PYRIMIDINE SCAFFOLD-BASED DERIVATIVES, FOR CANCER TREATMENT

Autor: RANGO, ENRICO

The first part of this thesis essentially focuses on the preclinical characterization of Si306, a pyrazolo[3,4-d]pyrimidine derivative, identified as a very promising anticancer agent. This compound has shown a favorable in vitro and in vivo activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c04aef68a1e2de1d7dec0a3f364bd5f
http://hdl.handle.net/11365/1140389

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