Zobrazeno 1 - 10
of 56
pro vyhledávání: '"4-Phenylpiperidine"'
Autor:
Maria Rosa Mazzoni, Elisabetta Orlandini, Gino Giannaccini, Susanna Nencetti, Gabriella Maria Pia Ortore, Laura Betti, Caterina Camodeca
Publikováno v:
ACS Chemical Neuroscience
The most commonly used antidepressant drugs are the serotonin transporter inhibitors. Their effects depend strongly on the selectivity for a single monoamine transporter compared to other amine transporters or receptors, and the selectivity is roughl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222e63cacf4a9e005f7cf67be240afde
http://hdl.handle.net/11568/1060301
http://hdl.handle.net/11568/1060301
Autor:
V. T. Panyushkin, R. A. Sharipov, V. K. Yu, V. A. Volynkin, K. S. Sharapov, K. D. Praliev, U. S. Kemel’bekov
Publikováno v:
Journal of Inclusion Phenomena and Macrocyclic Chemistry. 87:141-148
Inclusion complex of 4-acetoxy-1-(2-ethoxyethyl)-4-phenylpiperidine with β-cyclodextrin was synthesized. Composition (1:2) and the structure of the complex were confirmed by NMR spectroscopy and thermal analysis. The results of pharmacological studi
Autor:
Jörg Steinbach, Xia Wang, Hongmei Jia, Xiaojun Zhang, Peter Brust, Jinming Zhang, Jiajun Ye, Winnie Deuther-Conrad, Jianzhou Li, Liang Wang
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 59:332-339
We report the design and synthesis of several 4-phenylpiperidine-4-carbonitrile derivatives as σ1 receptor ligands. In vitro radioligand competition binding assays showed that all the ligands exhibited low nanomolar affinity for σ1 receptors (Ki(σ
Publikováno v:
Russian Chemical Bulletin. 65:834-839
Specific features of the structure of the synthesized inclusion complex of 4-acetoxy-1-(2ethoxyethyl)-4-phenylpiperidine with β-cyclodextrin were considered. The composition (1: 2) and structure of the obtained complex were confirmed by NMR spectros
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Publikováno v:
Advanced Materials Research. :263-267
A predictive 3D-QSAR model which correlates the biological activities with the chemical structures of a series of 4-phenylpiperidine derivatives as μ opioid agonists was developed by means of comparative molecular field analysis (CoMFA). The stabili
Autor:
Jacques Poupaert, Philip S. Portoghese
Publikováno v:
Bulletin des Sociétés Chimiques Belges. 86:863-867
A CD study of 8 representatives of 4-phenylpiperidine analgetics is presented to correlate their solid-state conformations with their chiroptical properties in solution. In addition to the benzenoid 1Lb fingerprint, the studied compounds exhibit two
Autor:
Anatoly T. Soldatenkov, Le Tuan Anh, Tran Thanh Tung, Zh. A. Mamyrbekova, V. N. Khrustalev, S. A. Soldatova, K. B. Polyanskiy
Publikováno v:
Chemistry of Heterocyclic Compounds. 44:1404-1412
4,8a-Diphenyl-substituted 2-(2-propoxy)perhydro[1,3,2]dioxaborinino[5.4-c]pyridine was obtained by the condensation of 4-hydroxy-3-(α-hydroxybenzyl)-1-methyl-4-phenylpiperidine with triisopropyl borate, and its 2-hydroxysubstituted analog in the pre
Publikováno v:
The FASEB Journal. 29
Publikováno v:
Tetrahedron Letters. 52:1199-1201
Liquid–liquid phase transfer conditions have been found to provide highly selective monoalkylation of tert-butyl 3,4-dihydroxy-4-phenylpiperidine-1-carboxylate, a transformation for which many other common alkylation protocols proved inadequate. Th