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Akademický článek
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Publikováno v:
Engineering Biology (2020)
Inducible genetic switches based on tyrosine recombinase-based DNA excision are a promising platform for the regulation and control of chimeric antigen receptor (CAR) T cell activity in cancer immunotherapy. These switches exploit the increased stabi
Externí odkaz:
https://doaj.org/article/53138d4c7d29466fb5d54aaab9de8cc7
Autor:
Belak, Monika
Nadzor imunskih celic T, ki izražajo himerni antigenski receptor (CAR-T celice, angl. Chimeric Antigen Receptor T cells) z uporabo destabilizacijskih domen, je pomembno orodje za natančno in prilagodljivo regulacijo aktivnosti celic CAR-T. Destabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3505::4e7222d8e49355024ca787f3d7ed0f0c
https://repozitorij.uni-lj.si/Dokument.php?id=170673&dn=
https://repozitorij.uni-lj.si/Dokument.php?id=170673&dn=
Autor:
Ivan Quétier, Jacqueline J.T. Marshall, Bradley Spencer-Dene, Sylvie Lachmann, Adele Casamassima, Claudio Franco, Sarah Escuin, Joseph T. Worrall, Priththivika Baskaran, Vinothini Rajeeve, Michael Howell, Andrew J. Copp, Gordon Stamp, Ian Rosewell, Pedro Cutillas, Holger Gerhardt, Peter J. Parker, Angus J.M. Cameron
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 440-448 (2016)
In animals, the protein kinase C (PKC) family has expanded into diversely regulated subgroups, including the Rho family-responsive PKN kinases. Here, we describe knockouts of all three mouse PKN isoforms and reveal that PKN2 loss results in lethality
Externí odkaz:
https://doaj.org/article/96edc553b94e4ce0be7befee57ac296c
Publikováno v:
Neuroscience
Highlights • Human hippocampal progenitor cells (HPCs) and tissue express classical sex hormone receptors. • Prolactin does not impact human HPCs maintained in a proliferative state. • Prolactin increases neuronal differentiation of human HPCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79be9ca5ba6757d62536be1fef095375
http://europepmc.org/articles/PMC7839971
http://europepmc.org/articles/PMC7839971
Autor:
Ahmed Emam Abdelnaby, Ryan E. Yoast, Jung Min Han, Natalia Lakomski, Vikas Arige, Scott M. Emrich, David I. Yule, James Sneyd, Geneviève Dupont, J. Cory Benson, Mohamed Trebak, Martin Johnson, Xuexin Zhang, Trayambak Pathak, Ping Xin, Nadine Hempel
Publikováno v:
The Journal of biological chemistry, 279 (4
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Mitochondrial Ca2+ uptake tailors the strength of stimulation of plasma membrane phospholipase C–coupled receptors to that of cellular bioenergetics. However, how Ca2+ uptake by the mitochondrial Ca2+ uniporter (MCU) shapes receptor-evoked interorg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203ae3650d01b502a62b4333bd567b31
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/333671
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/333671
Autor:
Xueying Tian, Bin Zhou
Publikováno v:
The Journal of Biological Chemistry
Site-specific recombinases (SSRs) are invaluable genome engineering tools that have enormously boosted our understanding of gene functions and cell lineage relationships in developmental biology, stem cell biology, regenerative medicine, and multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd835550bfb4c5ce331da13d1125a3f
http://europepmc.org/articles/PMC8050033
http://europepmc.org/articles/PMC8050033
Autor:
Tim Wallis, David C. Hancock, Aiman Alzetani, Anna Rattu, Rob M. Ewing, Ben G. Marshall, Yilu Zhou, Mark Jones, Franco Conforti, Julian Downward, Paul Skipp, Leanne Wickens, Donna E. Davies, Juanjuan Li, Sophie V. Fletcher, Fathima Maneesha Ibrahim, Luca Richeldi, Liudi Yao, Yihua Wang
Publikováno v:
The Journal of Biological Chemistry
Idiopathic pulmonary fibrosis (IPF) is the prototypic progressive fibrotic lung disease with a median survival of 2 to 4 years. Injury to and/or dysfunction of the alveolar epithelium is strongly implicated in IPF disease initiation, but the factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b544c8092b2c24aec7c311ded9edc111
Autor:
Tomio Ono, Satoshi Yamazaki, Kaoru Mita-Yoshida, Yasumasa Nishito, Hisao Masai, Naoko Yoshizawa-Sugata
Publikováno v:
The Journal of Biological Chemistry
Rif1 regulates DNA replication timing and double-strand break repair, and its depletion induces transcriptional bursting of 2-cell (2C) zygote-specific genes in mouse ES cells. However, how Rif1 regulates zygotic transcription is unclear. We show her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b5e1dc373f25211d250f4f7ee32408
https://doi.org/10.1016/j.jbc.2021.101367
https://doi.org/10.1016/j.jbc.2021.101367
Akademický článek
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