Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity.

Autor: Hamouda AEI; Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.; Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Filtjens J; etherna, Ghent, Belgium., Brabants E; etherna, Ghent, Belgium., Kancheva D; Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.; Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Debraekeleer A; Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.; Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Brughmans J; Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.; Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Jacobs L; etherna, Ghent, Belgium., Bardet PMR; Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.; Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Knetemann E; Liver Cell Biology Research Group, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Lefesvre P; Department of Anatomo-Pathology, Universitair Ziekenhuis Brussel (UZB), Brussels, Belgium., Allonsius L; Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.; Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Gontsarik M; Department of Pharmaceutics, University of Ghent, Ghent, Belgium., Varela I; etherna, Ghent, Belgium., Crabbé M; etherna, Ghent, Belgium., Clappaert EJ; Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.; Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium., Cappellesso F; Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.; Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Caro AA; Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.; Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; Laboratory of Tumor Immunology and Immunotherapy, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium., Gordún Peiró A; Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.; Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; Laboratory of Tumor Immunology and Immunotherapy, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium., Fredericq L; Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.; Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium., Hadadi E; Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.; Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium., Estapé Senti M; CDL Research, University Medical Center, Utrecht, The Netherlands., Schiffelers R; CDL Research, University Medical Center, Utrecht, The Netherlands., van Grunsven LA; Liver Cell Biology Research Group, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Aboubakar Nana F; Institut de Duve, Université Catholique de Louvain, Brussels, Belgium.; Service de Pneumologie, Cliniques Universitaires Saint-Luc, Brussels, Belgium., De Geest BG; Department of Pharmaceutics, University of Ghent, Ghent, Belgium., Deschoemaeker S; Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.; Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium., De Koker S; etherna, Ghent, Belgium., Lambolez F; etherna, Ghent, Belgium. florence.lambolez@etherna.be., Laoui D; Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium. dlaoui@vub.be.; Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium. dlaoui@vub.be.

Publikováno v: Nature communications [Nat Commun] 2024 Dec 06; Vol. 15 (1), pp. 10635. Date of Electronic Publication: 2024 Dec 06.

CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy.

Autor: Qiu F; Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Shenzhen, 518110, Guangdong, China.; Center for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, Guangdong, China.; Guangdong Medical University, Zhanjiang, Guangdong, China., Liu Y; Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Shenzhen, 518110, Guangdong, China., Liu Y; Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Shenzhen, 518110, Guangdong, China., Zhao Z; Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Shenzhen, 518110, Guangdong, China., Zhou L; Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Shenzhen, 518110, Guangdong, China., Chen P; Department of Traumatic Orthopedics, Shenzhen Longhua District Central Hospital, Shenzhen, China., Du Y; Department of Critical Care Medicine, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China., Wang Y; Department of Critical Care Medicine, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China., Sun H; Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China., Zeng C; Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China., Wang X; Department of Pharmacy, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China., Liu Y; Department of Anesthesiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518025, Guangdong, China. yq_liu886@163.com., Pan H; Center for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, Guangdong, China. hb.pan@siat.ac.cn., Ke C; Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Shenzhen, 518110, Guangdong, China. kekey88@163.com.

Publikováno v: Neuromolecular medicine [Neuromolecular Med] 2023 Dec; Vol. 25 (4), pp. 616-631. Date of Electronic Publication: 2023 Oct 05.

4-1BB-4-1BBL cis-interaction contributes to the survival of self-reactive CD8 ⁺ T cell.

Autor: Cho E; Immuno-oncology Branch, Division of Rare and Refractory Cancer, National Cancer Center, Goyang, 10408, Republic of Korea.; Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea., Singh R; Immuno-oncology Branch, Division of Rare and Refractory Cancer, National Cancer Center, Goyang, 10408, Republic of Korea., Han C; Immuno-oncology Branch, Division of Rare and Refractory Cancer, National Cancer Center, Goyang, 10408, Republic of Korea.; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, 10408, Republic of Korea., Kim SH; Immuno-oncology Branch, Division of Rare and Refractory Cancer, National Cancer Center, Goyang, 10408, Republic of Korea.; Department of Biomedical Laboratory Science, Catholic Kwandong University, Gangneung, 25601, Republic of Korea., Kim KH; Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea., Park BM; Biomedicine Production Branch, Research Institute, National Cancer Center, Goyang, 10408, Republic of Korea., Shin DH; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, 10408, Republic of Korea.; Anticancer Resistance Branch, Division of Rare and Refractory Cancer, Research Institute, National Cancer Center, Goyang, 10408, Republic of Korea., Han S; Immuno-oncology Branch, Division of Rare and Refractory Cancer, National Cancer Center, Goyang, 10408, Republic of Korea., Kim YH; Eutilex Co., Ltd., Geumcheon-gu, Seoul, 08594, Republic of Korea., Kwon BS; Eutilex Co., Ltd., Geumcheon-gu, Seoul, 08594, Republic of Korea.; Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, 70112, USA., Nam KT; Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea. kitaek@yuhs.ac., Choi BK; Immuno-oncology Branch, Division of Rare and Refractory Cancer, National Cancer Center, Goyang, 10408, Republic of Korea. magetin@gmail.com.; Innobationbio Co., Ltd., Mapo-gu, Seoul, 03929, Republic of Korea. magetin@gmail.com.

Publikováno v: Cellular & molecular immunology [Cell Mol Immunol] 2023 Sep; Vol. 20 (9), pp. 1077-1080. Date of Electronic Publication: 2023 Jun 26.

Batf3 ⁺ DCs and the 4-1BB/4-1BBL axis are required at the effector phase in the tumor microenvironment for PD-1/PD-L1 blockade efficacy.

Autor: Ziblat A; Department of Pathology, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA., Horton BL; Department of Pathology, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA., Higgs EF; Department of Pathology, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA., Hatogai K; Department of Pathology, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA., Martinez A; Department of Pathology, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA., Shapiro JW; Center for Research Informatics, University of Chicago, Chicago, IL 60637, USA., Kim DEC; Department of Pathology, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA., Zha Y; Human Immunological Monitoring Facility, University of Chicago, Chicago, IL 60637, USA., Sweis RF; Department of Medicine, University of Chicago, Chicago, IL 60612, USA., Gajewski TF; Department of Pathology, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA; Department of Medicine, University of Chicago, Chicago, IL 60612, USA. Electronic address: tgajewsk@bsd.uchicago.edu.

Publikováno v: Cell reports [Cell Rep] 2024 May 28; Vol. 43 (5), pp. 114141. Date of Electronic Publication: 2024 Apr 23.

CD137L and CD4 T cells limit BCL6-expressing pre-germinal center B cell expansion and BCL6-driven B cell malignancy.

Autor: Ding Z; Department of Immunology and Pathology, Alfred Medical Research and Education Precinct, Monash University, Melbourne, VIC, Australia., Quast I; Department of Immunology and Pathology, Alfred Medical Research and Education Precinct, Monash University, Melbourne, VIC, Australia., Yan F; Australian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, VIC, Australia., Liao Y; Olivia Newton John Cancer Research Institute, Melbourne, VIC, Australia., Pitt C; Department of Immunology and Pathology, Alfred Medical Research and Education Precinct, Monash University, Melbourne, VIC, Australia., O-Donnell K; Department of Immunology and Pathology, Alfred Medical Research and Education Precinct, Monash University, Melbourne, VIC, Australia., Robinson MJ; Department of Immunology and Pathology, Alfred Medical Research and Education Precinct, Monash University, Melbourne, VIC, Australia., Shi W; Olivia Newton John Cancer Research Institute, Melbourne, VIC, Australia.; School of Medicine, La Trobe University, Heidelberg, VIC, Australia., Kallies A; The Peter Doherty Institute, University of Melbourne, Melbourne, VIC, Australia., Zotos D; Department of Immunology and Pathology, Alfred Medical Research and Education Precinct, Monash University, Melbourne, VIC, Australia., Tarlinton DM; Department of Immunology and Pathology, Alfred Medical Research and Education Precinct, Monash University, Melbourne, VIC, Australia.

Publikováno v: Immunology and cell biology [Immunol Cell Biol] 2022 Oct; Vol. 100 (9), pp. 705-717. Date of Electronic Publication: 2022 Aug 17.