Výsledky vyhledávání - "4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 formyl 4 methylphenoxymethyl]benzonitrile"

Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1

Autor: Przemyslaw Grudnik, Lukasz Skalniak, Bogdan Musielak, Katarzyna Magiera, Grzegorz Dubin, Tad A. Holak, Krzysztof M. Zak, Ricarda Törner, Alexander Dömling, Katarzyna Guzik

Publikováno v: Journal of Medicinal Chemistry, 60(13), 5857-5867. AMER CHEMICAL SOC

Blockade of the PD-1/PD-L1 immune checkpoint pathway with monoclonal antibodies has provided significant advances in cancer treatment. The antibody-based immunotherapies carry a number of disadvantages such as the high cost of the antibodies, their l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625d97b965a27503a0c562a8cfaf459d
https://pubmed.ncbi.nlm.nih.gov/28613862

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