Zobrazeno 1 - 10
of 186
pro vyhledávání: '"3R Principle"'
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 14, Iss 5, Pp 553-560 (2024)
INTRODUCTION. Raw materials of biological origin can contaminate medicines with depressor substances, such as histamine, acetylcholine, bradykinin, serotonin, and prostaglandins. In the Russian Federation, tests for the content of these impurities ar
Externí odkaz:
https://doaj.org/article/a4ca603279db4f1391bc5cdd44d20c72
Publikováno v:
International Journal of Sustainable Engineering, Vol 17, Iss 1, Pp 1-20 (2024)
The Institute of Engineering (IOE), Pulchowk Campus in Lalitpur, Nepal, faces serious solid waste mismanagement issues that threaten the environment and public health. In a comprehensive investigation from June 5 to 12 June 2022, IOE students sorted
Externí odkaz:
https://doaj.org/article/853b279e01b440658b52e753af41583e
Publikováno v:
Environment International, Vol 186, Iss , Pp 108607- (2024)
Practical, legal, and ethical reasons necessitate the development of methods to replace animal experiments. Computational techniques to acquire information that traditionally relied on animal testing are considered a crucial pillar among these so-cal
Externí odkaz:
https://doaj.org/article/a767a2aa373a49f3a02c1c05ccf101d6
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 263, Iss , Pp 115250- (2023)
A major challenge in ecological risk assessment is estimating chemical-induced effects across taxa without species-specific testing. Where ecotoxicological data may be more challenging to gather, information on species physiology is more available fo
Externí odkaz:
https://doaj.org/article/46e84d3148ba4764a5e5073ae83f69af
Autor:
Astrid Enkelmann, Sabine J. Bischoff
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
The 3Rs principle is highly topical in animal-based research. These include, above all, new scientific methods for conducting experiments without an animal model, by using non-animal models (Replace), reducing the number of laboratory animals (Reduct
Externí odkaz:
https://doaj.org/article/739d82f6c4d644c7a6ec21e2b8b4c064
Potential of Electrospun Fibrous Scaffolds for Intestinal, Skin, and Lung Epithelial Tissue Modeling
Autor:
Andreia M. Gonçalves, Filipa Leal, Anabela Moreira, Tobias Schellhorn, Veronika Hefka Blahnová, Scarlett Zeiringer, Karolina Vocetková, Carolin Tetyczka, Aiva Simaite, Matej Buzgo, Eva Roblegg, Pedro F. Costa, Peter Ertl, Eva Filová, Yvonne Kohl
Publikováno v:
Advanced NanoBiomed Research, Vol 3, Iss 4, Pp n/a-n/a (2023)
Herein, intestinal, skin, and pulmonary in vitro tissue models based on electrospun membranes of poly(ε‐caprolactone) (PCL) and cellulose acetate (CA), cellulose acetate phthalate (CAP), ethylcellulose (EC), or methylcellulose (MC) are presented.
Externí odkaz:
https://doaj.org/article/64a58d4b8e81407d954c7d5558132342
Akademický článek
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Autor:
Patrick Stephan Sebastian, Nina Król, María Belén Novoa, Ard Menzo Nijhof, Martin Pfeffer, Santiago Nava, Anna Obiegala
Publikováno v:
Microorganisms, Vol 11, Iss 5, p 1107 (2023)
Hard ticks pose a threat to animal and human health. Active life stages need to feed on a vertebrate host in order to complete their life cycle. To study processes such as tick-pathogen interactions or drug efficacy and pharmacokinetics, it is necess
Externí odkaz:
https://doaj.org/article/4a4beb6b4e3140f6b3f1410324eff7e4
Publikováno v:
Advanced Science, Vol 9, Iss 10, Pp n/a-n/a (2022)
Abstract With the definition of the 3R principle by Russel and Burch in 1959, the search for an adequate substitute for animal testing has become one of the most important tasks and challenges of this time, not only from an ethical, but also from a s
Externí odkaz:
https://doaj.org/article/8c1d83faa0ed49898d6e8b24a9a0e447
Akademický článek
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