Zobrazeno 1 - 10
of 6 095
pro vyhledávání: '"3D-QSAR"'
Autor:
EL-Mernissi Reda, Alaqarbeh Marwa, Khaldan Ayoub, Kara Mohammed, Al kamaly Omkulthom, Alnakhli Anwar M., Lakhlifi Tahar, Sbai Abdelouahid, Ajana Mohammed Aziz, Bouachrine Mohammed
Publikováno v:
Open Chemistry, Vol 22, Iss 1, Pp 354-61 (2024)
Breast cancer is the most common illness among women, accounting for 25% of all diagnoses, as stated by the American Cancer Society. Current research focuses on 43 compounds of styrylquinoline derivatives as potential inhibitors of tubulin to design
Externí odkaz:
https://doaj.org/article/ec89b799f4c94f198c0819c5b4c36265
Autor:
Caiyue Liu, Yuelan Yin, Hao Liu, Longfei Yang, Minghui Chen, Ting Ma, Guoqiang Zhang, Chunjuan Wang, Sifeng Zhao, Xiaoqiang Han
Publikováno v:
Advanced Agrochem, Vol 3, Iss 2, Pp 171-181 (2024)
To discover novel and efficient compounds against Aphis gossypii Glover, a series of novel terpene ester derivatives containing the structure of bicyclo[2.2.1]heptane were designed and synthesized using tschimganin as the lead compound. Bioactivity a
Externí odkaz:
https://doaj.org/article/fc464eb1af274ac191514704ef9c42e3
Autor:
Priscila Goes Camargo, Carine Ribeiro dos Santos, Magaly Girão Albuquerque, Carlos Rangel Rodrigues, Camilo Henrique da Silva Lima
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-23 (2024)
Abstract Leishmaniasis is a disease caused by a protozoan of the genus Leishmania, affecting millions of people, mainly in tropical countries, due to poor social conditions and low economic development. First-line chemotherapeutic agents involve high
Externí odkaz:
https://doaj.org/article/978454de952c42ce9c0cc57dc144c2bb
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-28 (2024)
Abstract Decaprenylphosphoryl-β-D-ribose-2′-epimerase (DprE1), a crucial enzyme in the process of arabinogalactan and lipoarabinomannan biosynthesis, has become the target of choice for anti-TB drug discovery in the recent past. The current study
Externí odkaz:
https://doaj.org/article/e5e9f23baecf4dc9b2a4b614722a10dd
Autor:
Yanfeng Liu, Liangying Deng, Feng Ding, Qiang Wang, Shuran Zhang, Nana Mi, Wenhui Zhang, Bailin Zeng, Huangjin Tong, Lixing Wu
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-16 (2024)
Abstract Cholesteryl ester transfer protein (CETP) is a promising therapeutic target for cardiovascular diseases. It effectively lowers the low-density lipoprotein cholesterol levels and increases the high-density lipoprotein cholesterol levels in th
Externí odkaz:
https://doaj.org/article/90fb942c79524cd19977b7e84f3fe01a
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
ObjectiveBiological studies have elucidated that phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the serine synthesis pathway in humans that is abnormally expressed in numerous cancers. Inhibition of the PHGDH activity is though
Externí odkaz:
https://doaj.org/article/f0ebabd0fb9c407c804bb64209dc4023
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Akademický článek
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Autor:
Nedjla Khelfa, Salah Belaidi, Oussama Abchir, Imane Yamari, Samir Chtita, Abdelouahid Samadi, Muneerah Mogren Al-Mogren, Majdi Hochlaf
Publikováno v:
Scientific African, Vol 24, Iss , Pp e02202- (2024)
Plasmodium falciparum dihydrofolate reductase (PfDHFR) is a promising therapeutic target for antimalarial interventions. Diaminodihydrotriazine derivatives have demonstrated their efficacy as antimalarial agents by targeting PfDHFR inhibition. In thi
Externí odkaz:
https://doaj.org/article/ab45d1614d5e4ab2a876b2e531f99ecc