Zobrazeno 1 - 10
of 1 713
pro vyhledávání: '"3D genome"'
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 11, Pp 1156-1172 (2024)
Abstract The 3D genome prediction in cancer is crucial for uncovering the impact of structural variations (SVs) on tumorigenesis, especially when they are present in noncoding regions. We present InfoHiC, a systemic framework for predicting the 3D ca
Externí odkaz:
https://doaj.org/article/56ee9efbf26e48459167206cbba57bc8
Autor:
Mofan Feng, Liangjie Liu, Kai Su, Xianbin Su, Luming Meng, Zehua Guo, Dan Cao, Jiayi Wang, Guang He, Yi Shi
Publikováno v:
BMC Genomics, Vol 25, Iss S2, Pp 1-16 (2024)
Abstract Reliable and ultra-fast DNA and RNA sequencing have been achieved with the emergence of high-throughput sequencing technology. When combining the results of DNA and RNA sequencing for tumor cells of cancer patients, neoantigens that potentia
Externí odkaz:
https://doaj.org/article/043fca89c4d24e0ea85a89a96651c81c
Autor:
Sean M. Flynn, Somdutta Dhir, Krzysztof Herka, Colm Doyle, Larry Melidis, Angela Simeone, Winnie W. I. Hui, Rafael de Cesaris Araujo Tavares, Stefan Schoenfelder, David Tannahill, Shankar Balasubramanian
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Methods to measure chromatin contacts at genomic regions bound by histone modifications or proteins are important tools to investigate chromatin organization. However, such methods do not capture the possible involvement of other epigenomic
Externí odkaz:
https://doaj.org/article/64f8f18f52c349d5bcf820beb8d79a27
Autor:
Chrisostomos Drogaris, Yanlin Zhang, Eric Zhang, Elena Nazarova, Roman Sarrazin-Gendron, Sélik Wilhelm-Landry, Yan Cyr, Jacek Majewski, Mathieu Blanchette, Jérôme Waldispühl
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Over the past two decades, scientists have increasingly realized the importance of the three-dimensional (3D) genome organization in regulating cellular activity. Hi-C and related experiments yield 2D contact matrices that can be used to inf
Externí odkaz:
https://doaj.org/article/9883fb4235054b849ee2e9030d8e56ba
Publikováno v:
eLife, Vol 12 (2024)
In insects and mammals, 3D genome topology has been linked to transcriptional states yet whether this link holds for other eukaryotes is unclear. Using both ligation proximity and fluorescence microscopy assays, we show that in Saccharomyces cerevisi
Externí odkaz:
https://doaj.org/article/56f3a911554a435cbd94a079c9b4cbfa
Publikováno v:
eLife, Vol 13 (2024)
Some transcription factors (TFs) can form liquid–liquid phase separated (LLPS) condensates. However, the functions of these TF condensates in 3-Dimentional (3D) genome organization and gene regulation remain elusive. In response to methionine (met)
Externí odkaz:
https://doaj.org/article/b8a40d66bfcf464ab36ce17f37280377
Autor:
Eva D’haene, Víctor López-Soriano, Pedro Manuel Martínez-García, Soraya Kalayanamontri, Alfredo Dueñas Rey, Ana Sousa-Ortega, Silvia Naranjo, Stijn Van de Sompele, Lies Vantomme, Quinten Mahieu, Sarah Vergult, Ana Neto, José Luis Gómez-Skarmeta, Juan Ramón Martínez-Morales, Miriam Bauwens, Juan Jesús Tena, Elfride De Baere
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-24 (2024)
Abstract Background Vision depends on the interplay between photoreceptor cells of the neural retina and the underlying retinal pigment epithelium (RPE). Most genes involved in inherited retinal diseases display specific spatiotemporal expression wit
Externí odkaz:
https://doaj.org/article/a3d8d2ce3b6a449b865a48720cdd33d6
Autor:
Aura Stephenson-Gussinye, Luis A. Rendón-Bautista, Blanca E. Ruiz-Medina, Eduardo Blanco-Olais, Rosario Pérez-Molina, Cleofas Marcial-Medina, Yanin Chavarri-Guerra, Enrique Soto-Pérez-de-Celis, Andrea Morales-Alfaro, Ayerim Esquivel-López, Fernando Candanedo-González, Armando Gamboa-Domínguez, Rubén Cortes-González, Alejandro Alfaro-Goldaracena, Sara E. Vázquez-Manjarrez, Guido Grajales-Figueroa, Beatriz Astudillo-Romero, Jesús Ruiz-Manriquez, A. César Poot-Hernández, Paula Licona-Limón, Mayra Furlan-Magaril
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Molecular and cellular characterization of tumors is essential due to the complex and heterogeneous nature of cancer. In recent decades, many bioinformatic tools and experimental techniques have been developed to achieve personalized characterization
Externí odkaz:
https://doaj.org/article/331fba8ae42c45d880cce5649e067768
Publikováno v:
eLife, Vol 13 (2024)
The intricate structural organization of the human nucleus is fundamental to cellular function and gene regulation. Recent advancements in experimental techniques, including high-throughput sequencing and microscopy, have provided valuable insights i
Externí odkaz:
https://doaj.org/article/107637df2b5c41bba83bd4b5f6f1825e
Autor:
Arpit Mishra, Ajay Jajodia, Eryn Weston, Naresh Doni Jayavelu, Mariana Garcia, Daniel Hossack, R. David Hawkins
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Type I diabetes is an autoimmune disease mediated by T-cell destruction of β cells in pancreatic islets. Currently, there is no known cure, and treatment consists of daily insulin injections. Genome-wide association studies and twin studies have ind
Externí odkaz:
https://doaj.org/article/289347cc65d04d078c937b222b6228b9