Zobrazeno 1 - 10
of 1 692
pro vyhledávání: '"3D genome"'
Autor:
Chrisostomos Drogaris, Yanlin Zhang, Eric Zhang, Elena Nazarova, Roman Sarrazin-Gendron, Sélik Wilhelm-Landry, Yan Cyr, Jacek Majewski, Mathieu Blanchette, Jérôme Waldispühl
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Over the past two decades, scientists have increasingly realized the importance of the three-dimensional (3D) genome organization in regulating cellular activity. Hi-C and related experiments yield 2D contact matrices that can be used to inf
Externí odkaz:
https://doaj.org/article/9883fb4235054b849ee2e9030d8e56ba
Autor:
Sean M. Flynn, Somdutta Dhir, Krzysztof Herka, Colm Doyle, Larry Melidis, Angela Simeone, Winnie W. I. Hui, Rafael de Cesaris Araujo Tavares, Stefan Schoenfelder, David Tannahill, Shankar Balasubramanian
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Methods to measure chromatin contacts at genomic regions bound by histone modifications or proteins are important tools to investigate chromatin organization. However, such methods do not capture the possible involvement of other epigenomic
Externí odkaz:
https://doaj.org/article/64f8f18f52c349d5bcf820beb8d79a27
Autor:
Eva D’haene, Víctor López-Soriano, Pedro Manuel Martínez-García, Soraya Kalayanamontri, Alfredo Dueñas Rey, Ana Sousa-Ortega, Silvia Naranjo, Stijn Van de Sompele, Lies Vantomme, Quinten Mahieu, Sarah Vergult, Ana Neto, José Luis Gómez-Skarmeta, Juan Ramón Martínez-Morales, Miriam Bauwens, Juan Jesús Tena, Elfride De Baere
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-24 (2024)
Abstract Background Vision depends on the interplay between photoreceptor cells of the neural retina and the underlying retinal pigment epithelium (RPE). Most genes involved in inherited retinal diseases display specific spatiotemporal expression wit
Externí odkaz:
https://doaj.org/article/a3d8d2ce3b6a449b865a48720cdd33d6
Autor:
Aura Stephenson-Gussinye, Luis A. Rendón-Bautista, Blanca E. Ruiz-Medina, Eduardo Blanco-Olais, Rosario Pérez-Molina, Cleofas Marcial-Medina, Yanin Chavarri-Guerra, Enrique Soto-Pérez-de-Celis, Andrea Morales-Alfaro, Ayerim Esquivel-López, Fernando Candanedo-González, Armando Gamboa-Domínguez, Rubén Cortes-González, Alejandro Alfaro-Goldaracena, Sara E. Vázquez-Manjarrez, Guido Grajales-Figueroa, Beatriz Astudillo-Romero, Jesús Ruiz-Manriquez, A. César Poot-Hernández, Paula Licona-Limón, Mayra Furlan-Magaril
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Molecular and cellular characterization of tumors is essential due to the complex and heterogeneous nature of cancer. In recent decades, many bioinformatic tools and experimental techniques have been developed to achieve personalized characterization
Externí odkaz:
https://doaj.org/article/331fba8ae42c45d880cce5649e067768
Publikováno v:
eLife, Vol 13 (2024)
The intricate structural organization of the human nucleus is fundamental to cellular function and gene regulation. Recent advancements in experimental techniques, including high-throughput sequencing and microscopy, have provided valuable insights i
Externí odkaz:
https://doaj.org/article/107637df2b5c41bba83bd4b5f6f1825e
Autor:
Jie Cheng, Xiukai Cao, Shengxuan Wang, Jiaqiang Zhang, Binglin Yue, Xiaoyan Zhang, Yongzhen Huang, Xianyong Lan, Gang Ren, Hong Chen
Publikováno v:
Journal of Integrative Agriculture, Vol 23, Iss 1, Pp 39-58 (2024)
Eukaryotic genomes are hierarchically packaged into cell nucleus, affecting gene regulation. The genome is organized into multiscale structural units, including chromosome territories, compartments, topologically associating domains (TADs), and DNA l
Externí odkaz:
https://doaj.org/article/86ec7238abdd4ba2810f6df3bff9b3a6
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Arpit Mishra, Ajay Jajodia, Eryn Weston, Naresh Doni Jayavelu, Mariana Garcia, Daniel Hossack, R. David Hawkins
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Type I diabetes is an autoimmune disease mediated by T-cell destruction of β cells in pancreatic islets. Currently, there is no known cure, and treatment consists of daily insulin injections. Genome-wide association studies and twin studies have ind
Externí odkaz:
https://doaj.org/article/289347cc65d04d078c937b222b6228b9
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 5, Pp n/a-n/a (2024)
Abstract Background The three‐dimensional (3D) genome architecture plays a critical role inregulating gene expression. However, the specific alterations in thisarchitecture within somatotroph tumors and their implications for gene expression remain
Externí odkaz:
https://doaj.org/article/e3ec72533ddc4d279a679c798bbc5fc3
Autor:
Ningjun Duan, Yijia Hua, Xueqi Yan, Yaozhou He, Tianyu Zeng, Jue Gong, Ziyi Fu, Wei Li, Yongmei Yin
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract Secondary trastuzumab resistance represents an evolutionary adaptation of HER2‐positive breast cancer during anti‐HER2 treatment. Most current studies have tended to prioritize HER2 and its associated signaling pathways, often overlookin
Externí odkaz:
https://doaj.org/article/e14eb688c2e34550b89313acb25395d1