Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Autor: Eijsbouts, Chris, Zheng, Tenghao, Kennedy, Nicholas A., Bonfiglio, Ferdinando, Anderson, Carl A., Moutsianas, Loukas, Holliday, Joanne, Shi, Jingchunzi, Shringarpure, Suyash, Voda, Alexandru-Ioan, Farrugia, Gianrico, Franke, Andre, H��benthal, Matthias, Abecasis, Gon��alo, Zawistowski, Matthew, Skogholt, Anne Heidi, Ness-Jensen, Eivind, Hveem, Kristian, Esko, T��nu, Teder-Laving, Maris, Zhernakova, Alexandra, Camilleri, Michael, Boeckxstaens, Guy, Whorwell, Peter J., Spiller, Robin, McVean, Gil, D���Amato, Mauro, Jostins, Luke, Parkes, Miles, Agee, Michelle, Aslibekyan, Stella, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Clark, Sarah K., Elson, Sarah L., Fletez-Brant, Kipper, Fontanillas, Pierre, Furlotte, Nicholas A., Gandhi, Pooja M., Heilbron, Karl, Hicks, Barry, Hinds, David A., Huber, Karen E., Jewett, Ethan M., Jiang, Yunxuan, Kleinman, Aaron, Lin, Keng-Han, Litterman, Nadia K., Luff, Marie K., McCreight, Jey C., McIntyre, Matthew H., McManus, Kimberly F., Mountain, Joanna L., Mozaffari, Sahar V., Nandakumar, Priyanka, Noblin, Elizabeth S., Northover, Carrie A. M., O���Connell, Jared, Petrakovitz, Aaron A., Pitts, Steven J., Poznik, G. David, Sathirapongsasuti, J. Fah, Shastri, Anjali J., Shelton, Janie F., Tian, Chao, Tung, Joyce Y., Tunney, Robert J., Vacic, Vladimir, Wang, Xin, Zare, Amir S., Kashyap, Purna, Chang, Lin, Mayer, Emeran, Heitkemper, Margaret, Sayuk, Gregory S., Ringel-Kulka, Tamar, Ringel, Yehuda, Chey, William D., Eswaran, Shanti, Merchant, Juanita L., Shulman, Robert J., Bujanda, Luis, Garcia-Etxebarria, Koldo, Dlugosz, Aldona, Lindberg, Greger, Schmidt, Peter T., Karling, Pontus, Ohlsson, Bodil, Walter, Susanna, Faresj��, ��shild O., Simren, Magnus, Halfvarson, Jonas, Portincasa, Piero, Barbara, Giovanni, Usai-Satta, Paolo, Neri, Matteo, Nardone, Gerardo, Cuomo, Rosario, Galeazzi, Francesca, Bellini, Massimo, Latiano, Anna, Houghton, Lesley, Jonkers, Daisy, Kurilshikov, Alexander, Weersma, Rinse K., Netea, Mihai, Tesarz, Jonas, Gauss, Annika, Goebel-Stengel, Miriam, Andresen, Viola, Frieling, Thomas, Pehl, Christian, Schaefert, Rainer, Niesler, Beate, Lieb, Wolfgang, Hanevik, Kurt, Langeland, Nina, Wensaas, Knut-Arne, Litleskare, Sverre, Gabrielsen, Maiken E., Thomas, Laurent, Thijs, Vincent, Lemmens, Robin, Van Oudenhove, Lukas, Wouters, Mira

Publikováno v: Nature Genetics
Nature genetics, 53(11), 1543-1552. Nature Publishing Group

Funder: Kennedy Trust Rheumatology Research Prize Studentship
Funder: DFG Cluster of Excellence ���Precision Medicine in Chronic In-flammation��� (PMI; ID: EXC2167)
Funder: EC | EC Seventh Framework Programm | FP7 Ideas: Europea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d3e63ecdfa51d27cd4c008b5d1360d
https://doi.org/10.1038/s41588-021-00950-8

The trans-omics landscape of COVID-19

Autor: Wu, Peng, Chen, Dongsheng, Ding, Wencheng, Wu, Ping, Hou, Hongyan, Bai, Yong, Zhou, Yuwen, Li, Kezhen, Xiang, Shunian, Liu, Panhong, Ju, Jia, Guo, Ensong, Liu, Jia, Yang, Bin, Fan, Junpeng, He, Liang, Sun, Ziyong, Feng, Ling, Wang, Jian, Wu, Tangchun, Wang, Hao, Cheng, Jin, Xing, Hui, Meng, Yifan, Li, Yongsheng, Zhang, Yuanliang, Luo, Hongbo, Xie, Gang, Lan, Xianmei, Tao, Ye, Li, Jiafeng, Yuan, Hao, Huang, Kang, Sun, Wan, Qian, Xiaobo, Li, Zhichao, Huang, Mingxi, Ding, Peiwen, Wang, Haoyu, Qiu, Jiaying, Wang, Feiyue, Wang, Shiyou, Zhu, Jiacheng, Ding, Xiangning, Chai, Chaochao, Liang, Langchao, Wang, Xiaoling, Luo, Lihua, Sun, Yuzhe, Yang, Ying, Zhuang, Zhenkun, Li, Tao, Tian, Lei, Zhang, Shaoqiao, Zhu, Linnan, Chang, Ashley, Chen, Lei, Wu, Yiquan, Ma, Xiaoyan, Chen, Fang, Ren, Yan, Xu, Xun, Liu, Siqi, Yang, Huanming, Wang, Lin, Sun, Chaoyang, Ma, Ding, Jin, Xin, Chen, Gang

The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20c8e1c1411b708e87416c412cb14d5
https://www.repository.cam.ac.uk/handle/1810/325963

Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis

Autor: Graeme Davies, Julian L. Griffin, Anna Whitehead, Amanda D. V. MacCannell, Jürgen E. Schneider, Christopher Church, Steven A. Murfitt, Jason L. Scragg, Andrew J. Murray, Samuel Virtue, Fynn N. Krause, Edward Boateng, Jack Garnham, Amy Moran, Ben D. McNally, Antonio Vidal-Puig, Lee D. Roberts, Klaus K. Witte, James Dodgson, John Wright

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)

Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35c35aa1f5dc2a16de5ff5b842bce2a
http://europepmc.org/articles/PMC7998027

ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response

Autor: Adeyemo, Adebowale A., Zaghloul, Norann A., Chen, Guanjie, Doumatey, Ayo P., Leitch, Carmen C., Hostelley, Timothy L., Nesmith, Jessica E., Zhou, Jie, Bentley, Amy R., Shriner, Daniel, Fasanmade, Olufemi, Okafor, Godfrey, Eghan, Benjamin, Agyenim-Boateng, Kofi, Chandrasekharappa, Settara, Adeleye, Jokotade, Balogun, William, Owusu, Samuel, Amoah, Albert, Acheampong, Joseph, Johnson, Thomas, Oli, Johnnie, Adebamowo, Clement, Collins, Francis, Dunston, Georgia, Rotimi, Charles N., Chen, Ji, Sun, Meng, Pirie, Fraser, Carstensen, Tommy, Pomilla, Cristina, Young, Elizabeth H., Sandhu, Manjinder, Morris, Andrew P., Barroso, Inês, McCarthy, Mark I., Mahajan, Anubha, Wheeler, Eleanor, Motala, Ayesha A.

Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact. Here, we report a genome-wide analysis of type 2 diabetes (T2D) in sub-Saharan Africans,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7075fd67425695a9b1e90886e764b682

Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income

Autor: Shen Xueyi, David J. Porteous, Neil M Davies, Andrew M. McIntosh, Emanuele Di Angelantonio, Catharine R. Gale, Ian J. Deary, W. David Hill, David J. Roberts, Julien Bryois, Gail Davies, David C. Liewald, Nathan G. Skene, Steven Bell, Stuart J. Ritchie, Adam S. Butterworth, Caroline Hayward

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Hill, W D, Davies, N M, Ritchie, S J, Skene, N G, Bryois, J, Bell, S, Di Angelantonio, E, Roberts, D J, Xueyi, S, Davies, G, Liewald, D C M, Porteous, D J, Hayward, C, Butterworth, A S, Mcintosh, A M, Gale, C R & Deary, I J 2019, ' Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income ', Nature Communications, vol. 10, no. 1, 5741 . https://doi.org/10.1038/s41467-019-13585-5
Hill, W D, Davies, N M, Ritchie, S J, Skene, N G, Bryois, J, Bell, S, Di Angelantonio, E, Roberts, D J, Xueyi, S, Davies, G, Liewald, D C M, Porteous, D J, Hayward, C, Butterworth, A S, McIntosh, A M, Gale, C R & Deary, I J 2019, ' Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income ', Nature Communications, vol. 10, no. 1, 5741 . https://doi.org/10.1038/s41467-019-13585-5

Socioeconomic position (SEP) is a multi-dimensional construct reflecting (and influencing) multiple socio-cultural, physical, and environmental factors. In a sample of 286,301 participants from UK Biobank, we identify 30 (29 previously unreported) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359d7e03401cb5b627bd217a3645c0d4
https://www.repository.cam.ac.uk/handle/1810/315404