Zobrazeno 1 - 10
of 14
pro vyhledávání: '"38/109"'
Autor:
Hakkaart, Christopher, Pearson, John F, Marquart, Louise, Dennis, Joe, Wiggins, George AR, Barnes, Daniel R, Robinson, Bridget A, Mace, Peter D, Aittomäki, Kristiina, Andrulis, Irene L, Arun, Banu K, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B, Belhadj, Sami, Berger, Lieke, Blok, Marinus J, Boonen, Susanne E, Borde, Julika, Bradbury, Angela R, Brunet, Joan, Buys, Saundra S, Caligo, Maria A, Campbell, Ian, Chung, Wendy K, Claes, Kathleen BM, GEMO Study Collaborators, EMBRACE Collaborators, Collonge-Rame, Marie-Agnès, Cook, Jackie, Cosgrove, Casey, Couch, Fergus J, Daly, Mary B, Dandiker, Sita, Davidson, Rosemarie, De La Hoya, Miguel, De Putter, Robin, Delnatte, Capucine, Dhawan, Mallika, Diez, Orland, Ding, Yuan Chun, Domchek, Susan M, Donaldson, Alan, Eason, Jacqueline, Easton, Douglas F, Ehrencrona, Hans, Engel, Christoph, Evans, D Gareth, Faust, Ulrike, Feliubadaló, Lidia, Fostira, Florentia, Friedman, Eitan, Frone, Megan, Frost, Debra, Garber, Judy, Gayther, Simon A, Gehrig, Andrea, Gesta, Paul, Godwin, Andrew K, Goldgar, David E, Greene, Mark H, Hahnen, Eric, Hake, Christopher R, Hamann, Ute, Hansen, Thomas VO, Hauke, Jan, Hentschel, Julia, Herold, Natalie, Honisch, Ellen, Hulick, Peter J, Imyanitov, Evgeny N, SWE-BRCA Investigators, KConFab Investigators, HEBON Investigators, Isaacs, Claudine, Izatt, Louise, Izquierdo, Angel, Jakubowska, Anna, James, Paul A, Janavicius, Ramunas, John, Esther M, Joseph, Vijai, Karlan, Beth Y, Kemp, Zoe, Kirk, Judy, Konstantopoulou, Irene, Koudijs, Marco, Kwong, Ava, Laitman, Yael, Lalloo, Fiona, Lasset, Christine, Lautrup, Charlotte, Lazaro, Conxi, Legrand, Clémentine, Leslie, Goska, Lesueur, Fabienne, Mai, Phuong L, Manoukian, Siranoush, Mari, Véronique, Martens, John WM, McGuffog, Lesley, Mebirouk, Noura, Meindl, Alfons, Miller, Austin, Montagna, Marco, Moserle, Lidia, Mouret-Fourme, Emmanuelle, Musgrave, Hannah, Nambot, Sophie, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Yie, Joanne Ngeow Yuen, Nguyen-Dumont, Tu, Nikitina-Zake, Liene, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I, Osorio, Ana, Ott, Claus-Eric, Park, Sue K, Parsons, Michael T, Pedersen, Inge Sokilde, Peixoto, Ana, Perez-Segura, Pedro, Peterlongo, Paolo, Pocza, Timea, Radice, Paolo, Ramser, Juliane, Rantala, Johanna, Rodriguez, Gustavo C, Rønlund, Karina, Rosenberg, Efraim H, Rossing, Maria, Schmutzler, Rita K, Shah, Payal D, Sharif, Saba, Sharma, Priyanka, Side, Lucy E, Simard, Jacques, Singer, Christian F, Snape, Katie, Steinemann, Doris, Stoppa-Lyonnet, Dominique, Sutter, Christian, Tan, Yen Yen, Teixeira, Manuel R, Teo, Soo Hwang, Thomassen, Mads, Thull, Darcy L, Tischkowitz, Marc, Toland, Amanda E, Trainer, Alison H, Tripathi, Vishakha, Tung, Nadine, Van Engelen, Klaartje, Van Rensburg, Elizabeth J, Vega, Ana, Viel, Alessandra, Walker, Lisa, Weitzel, Jeffrey N, Wevers, Marike R, Chenevix-Trench, Georgia, Spurdle, Amanda B, Antoniou, Antonis C, Walker, Logan C
The contribution of germline copy number variants (CNVs) to risk of developing cancer in individuals with pathogenic BRCA1 or BRCA2 variants remains relatively unknown. We conducted the largest genome-wide analysis of CNVs in 15,342 BRCA1 and 10,740
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444b9427cde6163d24f6adc68f9fbbc1
Autor:
Patel, Saroor A, Hirosue, Shoko, Rodrigues, Paulo, Vojtasova, Erika, Richardson, Emma K, Ge, Jianfeng, Syafruddin, Saiful E, Speed, Alyson, Papachristou, Eva, Baker, David, Clarke, David, Purvis, Stephenie, Wesolowski, Ludovic, Dyas, Anna, Castillon, Leticia, Caraffini, Veronica, Bihary, Dóra, Yong, Cissy, Harrison, David J, Stewart, Grant, Machiela, Mitchell J, Purdue, Mark P, Chanock, Stephen J, Warren, Anne, Samarajiwa, Shamith A, Carroll, Jason, Vanharanta, Sakari
Large-scale human genetic data1-3 have shown that cancer mutations display strong tissue-selectivity, but how this selectivity arises remains unclear. Here, using experimental models, functional genomics and analyses of patient samples, we demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73fd3c6a5bdeb92e6648f4131d9c3372
Autor:
Novoyatleva, Tatyana, Rai, Nabham, Kojonazarov, Baktybek, Veeroju, Swathi, Ben-Batalla, Isabel, Caruso, Paola, Shihan, Mazen, Presser, Nadine, Götz, Elsa, Lepper, Carina, Herpel, Sebastian, Manaud, Grégoire, Perros, Frédéric, Gall, Henning, Ghofrani, Hossein Ardeschir, Weissmann, Norbert, Grimminger, Friedrich, Wharton, John, Wilkins, Martin, Upton, Paul D, Loges, Sonja, Morrell, Nicholas W, Seeger, Werner, Schermuly, Ralph T
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Communications Biology
Communications Biology
Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e., monocrotaline and Su5416/hypoxia treated r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55808d09bf69bcabbb77ddde5652041c
Autor:
Amra Saric, David C. Gershlick, Chad D. Williamson, Michael S. Fernandopulle, Carlos M. Guardia, Juan S. Bonifacino, Spencer A. Freeman, Michal Jarnik
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Funder: Intramural Program, National Institute of Child Health and Human Development, NIH, project # ZIA HD001607
The ability of endolysosomal organelles to move within the cytoplasm is essential for the performance of their functions. Long-rang
The ability of endolysosomal organelles to move within the cytoplasm is essential for the performance of their functions. Long-rang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005b3a95b2a13dd4f8a51125fe746701
https://www.repository.cam.ac.uk/handle/1810/327355
https://www.repository.cam.ac.uk/handle/1810/327355
Autor:
Sofia Tapanelli, Katarzyna A. Sala, George K. Christophides, Andrew M. Blagborough, Fiona Angrisano
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Inhibiting transmission of Plasmodium is an essential strategy in malaria eradication, and the biological process of gamete fusion during fertilization is a proven target for this approach. Lack of knowledge of the mechanisms underlying fertilization
Autor:
Petra Kodajova, Sonia Sánchez Martínez, Nicola A. Probst, Liam C. Lee, Ines Garces de los Fayos Alonso, Miaojun Han, Sandra Högler, Joaquín Pastor, G. A. Amos Burke, C. Patrick Reynolds, Hong Kai Lim, Eleanor Manners, Carmen Blanco-Aparicio, Leila Jahangiri, Jamie D. Matthews, Ji Luo, Suzanne D. Turner, Nina Prokoph, Simone Tangermann, Lukas Kenner, Olaf Merkel, Ricky M Trigg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications
Repisalud
Instituto de Salud Carlos III (ISCIII)
Resistance to anaplastic lymphoma kinase (ALK)-targeted therapy in ALK-positive non-small cell lung cancer has been reported, with the majority of acquired resistance mechanisms relying on bypass signaling. To proactively identify resistance mechanis
Autor:
David O. Bates, Eleanor Star, Sebastian Oltean, Steve J Harper, Christopher W.J. Smith, Monica Lamici Ayine, Ling Li, Clare Gooding, Megan Stevens
Publikováno v:
Oncogenesis, Vol 10, Iss 5, Pp 1-12 (2021)
Oncogenesis
Oncogenesis
Funder: RCUK | Biotechnology and Biological Sciences Research Council (BBSRC); doi: https://doi.org/10.13039/501100000268
Funder: Diabetes UK; doi: https://doi.org/10.13039/501100000361
Alternative splicing of the vascular endothelial growt
Funder: Diabetes UK; doi: https://doi.org/10.13039/501100000361
Alternative splicing of the vascular endothelial growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e712dfbfd96868b2faa40bc0a68afc
Autor:
Clara Lopes Novo, Emily V. Wong, Colin Hockings, Chetan Poudel, Eleanor Sheekey, Meike Wiese, Hanneke Okkenhaug, Simon J. Boulton, Srinjan Basu, Simon Walker, Gabriele S. Kaminski Schierle, Geeta J. Narlikar, Peter J. Rugg-Gunn
Publikováno v:
Nature communications, vol 13, iss 1
Heterochromatin maintains genome integrity and function, and is organised into distinct nuclear domains. Some of these domains are proposed to form by phase separation through the accumulation of HP1ɑ. Mouse heterochromatin contains noncoding major
Autor:
Adeyemo, Adebowale A., Zaghloul, Norann A., Chen, Guanjie, Doumatey, Ayo P., Leitch, Carmen C., Hostelley, Timothy L., Nesmith, Jessica E., Zhou, Jie, Bentley, Amy R., Shriner, Daniel, Fasanmade, Olufemi, Okafor, Godfrey, Eghan, Benjamin, Agyenim-Boateng, Kofi, Chandrasekharappa, Settara, Adeleye, Jokotade, Balogun, William, Owusu, Samuel, Amoah, Albert, Acheampong, Joseph, Johnson, Thomas, Oli, Johnnie, Adebamowo, Clement, Collins, Francis, Dunston, Georgia, Rotimi, Charles N., Chen, Ji, Sun, Meng, Pirie, Fraser, Carstensen, Tommy, Pomilla, Cristina, Young, Elizabeth H., Sandhu, Manjinder, Morris, Andrew P., Barroso, Inês, McCarthy, Mark I., Mahajan, Anubha, Wheeler, Eleanor, Motala, Ayesha A.
Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact. Here, we report a genome-wide analysis of type 2 diabetes (T2D) in sub-Saharan Africans,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7075fd67425695a9b1e90886e764b682
Autor:
Robert J. Lee, Frances A. Collins, George S. Vassiliou, Yi Zheng, Andreas Petri, Krzysztof Mrózek, Sara Terreri, Prasanthi Kumchala, Christopher J. Walker, Deedra Nicolet, Kellie J. Archer, Michael A. Freitas, Nina C. Zitzer, Felice Pepe, Guramrit Singh, Eric Wang, Allison E. Walker, Virginia Camilotto, Sakari Kauppinen, Adrienne M. Dorrance, Lauren A. Woodward, Miranda L. Gardner, Jonathan L. Cooper, Ramiro Garzon, Jessica Kohlschmidt, Dimitrios Papaioannou, Xiongwei Cai, Xiaoqing Rong-Mullins, Iannis Aifantis, Clara D. Bloomfield, Marius Bill, Oliver M. Dovey, Malith Karunasiri
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Papaioannou, D, Petri, A, Dovey, O M, Terreri, S, Wang, E, Collins, F A, Woodward, L A, Walker, A E, Nicolet, D, Pepe, F, Kumchala, P, Bill, M, Walker, C J, Karunasiri, M, Mrózek, K, Gardner, M L, Camilotto, V, Zitzer, N, Cooper, J L, Cai, X, Rong-Mullins, X, Kohlschmidt, J, Archer, K J, Freitas, M A, Zheng, Y, Lee, R J, Aifantis, I, Vassiliou, G, Singh, G, Kauppinen, S, Bloomfield, C D, Dorrance, A M & Garzon, R 2019, ' The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia ', Nature Communications, vol. 10, no. 1, 5351 . https://doi.org/10.1038/s41467-019-13259-2
Nature Communications
Papaioannou, D, Petri, A, Dovey, O M, Terreri, S, Wang, E, Collins, F A, Woodward, L A, Walker, A E, Nicolet, D, Pepe, F, Kumchala, P, Bill, M, Walker, C J, Karunasiri, M, Mrózek, K, Gardner, M L, Camilotto, V, Zitzer, N, Cooper, J L, Cai, X, Rong-Mullins, X, Kohlschmidt, J, Archer, K J, Freitas, M A, Zheng, Y, Lee, R J, Aifantis, I, Vassiliou, G, Singh, G, Kauppinen, S, Bloomfield, C D, Dorrance, A M & Garzon, R 2019, ' The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia ', Nature Communications, vol. 10, no. 1, 5351 . https://doi.org/10.1038/s41467-019-13259-2
Nature Communications
Long non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in cellular physiology and pathology. In this work, we dissect the functional role of the HOXB-AS3 lncRNA in patients with NPM1-mutated (NPM1mut) acute myeloid leuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43af3f5cfc7c1d83ce5e4144993eaf2b
https://www.repository.cam.ac.uk/handle/1810/299643
https://www.repository.cam.ac.uk/handle/1810/299643