Zobrazeno 1 - 10
of 60
pro vyhledávání: '"3102 Bioinformatics and Computational Biology"'
We report the complete genome sequence of the Ornithobacterium hominis type strain MSHR-COH1 (ATCC TSD-185/NCTC 14317), a bacterial species isolated from the human nasopharynx. Long-read sequencing reveals that the genome is 2,036,909 bp in length, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfde7de28e5cde32297d3fce8b348ba
https://www.repository.cam.ac.uk/handle/1810/350883
https://www.repository.cam.ac.uk/handle/1810/350883
Motivation The advent of long-read DNA sequencing is allowing complete assembly of highly repetitive genomic regions for the first time, including the megabase-scale satellite repeat arrays found in many eukaryotic centromeres. The assembly of such r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee29701f2e8cde96f18fe3f017a8ba2
Autor:
Stacey, David, Fauman, Eric, Ziemek, Daniel, Sun, Benjamin, Harshfield, Eric, Wood, Angela, Butterworth, Adam, Suhre, Karsten, Paul, Dirk
Quantitative trait locus (QTL) mapping of molecular phenotypes such as metabolites, lipids, and proteins through genome-wide association studies (GWAS) represents a powerful means of highlighting molecular mechanisms relevant to human diseases. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bdf62e5ca162c87b35a32350fae411
Autor:
Xu, Zhuang
Distinct localisation of macromolecular structures relative to cell shape is a common feature across the domains of life. One mechanism for achieving spatiotemporal intracellular organisation is the Turing reaction-diffusion system (e.g. Min system i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c66d8cebaf398c73980a077e3c2c313
Autor:
Shah, Anushi
De novo mutations (DNMs) are novel mutations which occur for the first time in an offspring and are not inherited from the parents. High-Throughput Sequencing (HTS) technologies such as whole genome sequencing (WGS) and whole exome sequencing (WES) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbfbd083ffe5af9e7179b5c162192db4
Autor:
Kieran O. Russell, Rosana Collepardo-Guevara, Adiran Garaizar, Anne Aguirre, Jorge R. Espinosa, Jerelle A. Joseph, Pin Yu Chew, Aleks Reinhardt
Publikováno v:
Nature Computational Science
Nat Comput Sci
Nat Comput Sci
Various physics- and data-driven sequence-dependent protein coarse-grained models have been developed to study biomolecular phase separation and elucidate the dominant physicochemical driving forces. Here we present Mpipi, a multiscale coarse-grained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85944a747dfdb2685d0df54e8a21015d
https://doi.org/10.1038/s43588-021-00155-3
https://doi.org/10.1038/s43588-021-00155-3
Despite increasingly detailed knowledge of gene expression patterns, the regulatory architectures that drive them are not well understood. To address this, we compared transcriptional and regulatory element activities across five adult tissues ofC. e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51ab02de7d499a3fcb952be9b1b4c8e
Transfer RNAs (tRNAs) are ubiquitous adapter molecules that link specific codons in messenger RNA (mRNA) with their corresponding amino acids during protein synthesis. The tRNA genes of Drosophila have been investigated for over half a century but ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79243034dafe022632daf4994b34462f
Autor:
Zhang, Mengqi, Guo, F Richard
MOTIVATION: Single-cell sequencing brings about a revolutionarily high resolution for finding differentially expressed genes by disentangling highly heterogeneous cell tissues. Yet, such analysis is so far mostly focused on comparing between differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d8959b4e64c6b1165b82d0340a6151
Autor:
Jahangiri, Leila
Publikováno v:
Onco; Volume 2; Issue 2; Pages: 85-112
A complex interaction occurs between cancer cells and the extracellular matrix (ECM) in the tumour microenvironment (TME). In this study, the expressions and mutational profiles of 964 ECM-related genes and their correlations with patient overall sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66833aff8555dd3c47381f760cc72af
https://www.repository.cam.ac.uk/handle/1810/337359
https://www.repository.cam.ac.uk/handle/1810/337359