Zobrazeno 1 - 10
of 154
pro vyhledávání: '"3000 General Pharmacology, Toxicology and Pharmaceutics"'
Autor:
Vasil Kecheliev, Leo Boss, Upasana Maheshwari, Uwe Konietzko, Annika Keller, Daniel Razansky, Roger M. Nitsch, Jan Klohs, Ruiqing Ni
Publikováno v:
Life sciences, 321
Aims: Neurovascular-glymphatic dysfunction plays an important role in Alzheimer's disease and has been analysed mainly in relation to amyloid-beta (Aβ) pathology. Here, we aim to investigate the neurovascular alterations and mapping of aquaporin 4 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5db0d64b3925f7d82f3158c843ed1d4
https://hdl.handle.net/20.500.11850/606146
https://hdl.handle.net/20.500.11850/606146
Autor:
A. Dolbois, Elena Bochenkova, Amedeo Caflisch, Elena V. Moroz-Omori, Maciej D. Rzeczkowski, L. Wiedmer, Paweł Śledź, Sherry J. Cheriyamkunnel, R.K. Bedi, Danzhi Huang
Publikováno v:
Chemmedchem
The methylase METTL3 is the writer enzyme of the N6‐methyladenosine (m6A) modification of RNA. Using a structure‐based drug discovery approach, we identified a METTL3 inhibitor with potency in a biochemical assay of 280 nM, while its enantiomer i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d129e78a66bc0589b8e79fd2d55d07e
https://doi.org/10.1002/cmdc.202100291
https://doi.org/10.1002/cmdc.202100291
Autor:
Quirke, Jonathan C K, Sati, Girish C, Sonousi, Amr, Gysin, Marina, Haldimann, Klara, Böttger, Erik C, Vasella, Andrea, Hobbie, Sven N, Crich, David
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______885::80b7da9566ebbd3ac7e791bbb13b42f2
https://doi.org/10.5167/uzh-218834
https://doi.org/10.5167/uzh-218834
Autor:
van Spijk, Julia N, Beckmann, Katrin, Wehrli Eser, Meret, Stirn, Martina, Steuer, Andrea E, Saleh, Lanja, Schoster, Angelika
Publikováno v:
Antibiotics; Volume 12; Issue 5; Pages: 854
Neuro- and nephrotoxicity of polymyxins are known but clinical studies in horses are lacking. The aim of this study was to describe neurogenic and nephrogenic side effects of hospitalized horses receiving Polymyxin B (PolyB) as part of their treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb98c704d0c2b04fb71bc9645722b18e
https://doi.org/10.3390/antibiotics12050854
https://doi.org/10.3390/antibiotics12050854
Publikováno v:
ChemMedChem. 17
A rationally-designed scaffold of cyclic octapeptides composed of two units of the natural tripeptide glutathione (GSH) was optimized to strongly and selectively capture toxic lead ions (Pb(II)). Using state-of-the-art computational tools, a list of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2107b44d23a98b0e084d82137811163b
https://doi.org/10.1002/cmdc.202200152
https://doi.org/10.1002/cmdc.202200152
Autor:
Padrutt, Roxane, Babu, Vipin, Klingler, Simon, Kalt, Martina, Schumer, Frank, Anania, Maria I, Schneider, Lukas, Spingler, Bernhard
Publikováno v:
ChemMedChem. 16:694-701
We report the synthesis of the first transplatin-BODIPY conjugates for application in photodynamic therapy (PDT). The distyryl BODIPYs containing two iodine atoms were designed to absorb in the red region, easily undergo intersystem crossing for effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0ed1548ce0a82a3eb34b9a57eb4030
https://doi.org/10.1002/cmdc.202000702
https://doi.org/10.1002/cmdc.202000702
Publikováno v:
Antibiotics; Volume 11; Issue 2; Pages: 213
Schmitt, Kira; Biggel, Michael; Stephan, Roger; Willi, Barbara (2022). Massive Spread of OXA-48 Carbapenemase-Producing Enterobacteriaceae in the Environment of a Swiss Companion Animal Clinic. Antibiotics, 11(2) MDPI 10.3390/antibiotics11020213
Schmitt, Kira; Biggel, Michael; Stephan, Roger; Willi, Barbara (2022). Massive Spread of OXA-48 Carbapenemase-Producing Enterobacteriaceae in the Environment of a Swiss Companion Animal Clinic. Antibiotics, 11(2) MDPI 10.3390/antibiotics11020213
Background: Companion animal clinics contribute to the spread of antimicrobial resistant microorganisms (ARM) and outbreaks with ARM of public health concern have been described. Methods: As part of a project to assess infection prevention and contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c1952c0dff72f5d5b0f3fa3fb39ee0
Publikováno v:
Neuromethods ISBN: 9781071620380
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59cf1a5a050b3d640068cfe7e9dfe89
https://doi.org/10.1007/978-1-0716-2039-7_19
https://doi.org/10.1007/978-1-0716-2039-7_19
Autor:
Georgios Schoretsanitis, Ekkehard Haen, Daria Piacentino, Andreas Conca, Katharina Endres, Christoph Hiemke, Gerhard Gründer, Michael Paulzen
Publikováno v:
Expert review of clinical pharmacology. 15(2)
Knowledge about the impact of body composition features on pharmacokinetics of newer long-acting injectable antipsychotics is limited.We analyzed steady-state plasma concentrations of paliperidone in different body mass index (BMI), age, sex, and smo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d468a99e2d0b07451b20da93626c661b
https://pubmed.ncbi.nlm.nih.gov/34918984
https://pubmed.ncbi.nlm.nih.gov/34918984