Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism

Autor: Ivan Gallotta 1, 2, Nadia Mazzarella 1, Alessandra Donato 1, 3 Alessandro Esposito 1, Justin C. Chaplin 3, Silvana Castro 1, Giuseppina Zampi 1, Giorgio S. Battaglia 4, Massimo A. Hilliard 3, Paolo Bazzicalupo 1, Elia Di Schiavi 1

Publikováno v: Human molecular genetics
(2016): 1–14. doi:10.1093/hmg/ddw119
info:cnr-pdr/source/autori:Ivan Gallotta 1,2, Nadia Mazzarella 1,2, Alessandra Donato 1,3 Alessandro Esposito 1, Justin C. Chaplin 3, Silvana Castro 1, Giuseppina Zampi 1,2, Giorgio S. Battaglia 4, Massimo A. Hilliard 3, Paolo Bazzicalupo 1,2 and Elia Di Schiavi 1,2/titolo:Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism/doi:10.1093%2Fhmg%2Fddw119/rivista:Human molecular genetics (Print)/anno:2016/pagina_da:1/pagina_a:14/intervallo_pagine:1–14/volume
Human Molecular Genetics

Spinal muscular atrophy is a devastating disease that is characterized by degeneration and death of a specific subclass of motor neurons in the anterior horn of the spinal cord. Although the gene responsible, survival motor neuron 1 (SMN1), was ident

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