Zobrazeno 1 - 10
of 2 715
pro vyhledávání: '"3' Untranslated Region"'
Autor:
Daniel P. Neumann, Katherine A. Pillman, B. Kate Dredge, Andrew G. Bert, Caroline A. Phillips, Rachael Lumb, Yesha Ramani, Cameron P. Bracken, Brett G. Hollier, Luke A. Selth, Traude H. Beilharz, Gregory J. Goodall, Philip A. Gregory
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 199-209 (2024)
Epithelial-mesenchymal transition (EMT) plays important roles in tumour progression and is orchestrated by dynamic changes in gene expression. While it is well established that post-transcriptional regulation plays a significant role in EMT, the exte
Externí odkaz:
https://doaj.org/article/f948ce2e7da94619a7c424e6a9a539bd
Autor:
Eric M. Cockman, Vivek Narayan, Belinda Willard, Sumangala P. Shetty, Paul R. Copeland, Donna M. Driscoll
Publikováno v:
RNA Biology, Vol 16, Iss 12, Pp 1682-1696 (2024)
Selenoproteins are a unique class of proteins that contain the 21st amino acid, selenocysteine (Sec). Addition of Sec into a protein is achieved by recoding of the UGA stop codon. All 25 mammalian selenoprotein mRNAs possess a 3′ UTR stem-loop stru
Externí odkaz:
https://doaj.org/article/13e62b08d7d8470e88c3a2f0917b072a
Publikováno v:
Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101720- (2024)
We performed single-cell RNA sequencing (scRNA-seq) on a population of 5,000 Tetrahymena thermophila, using the 10x Genomics 3′ gene expression analysis, to investigate gene expression variability within this clonal population. Initially, we estima
Externí odkaz:
https://doaj.org/article/a685a53722974b4681fe1811a2ad89cc
Autor:
Igor Araujo Vieira, Guilherme Danielski Viola, Eduarda Heidrich Pezzi, Thayne Woycinck Kowalski, Bruna Vieira Fernandes, Tiago Finger Andreis, Natascha Bom, Giulianna Sonnenstrahl, Yasminne Marinho de Araújo Rocha, Bruno da Silveira Corrêa, Luiza Mezzomo Donatti, Gabriela dos Santos Sant’Anna, Helena von Eye Corleta, Ilma Simoni Brum, Clévia Rosset, Fernanda Sales Luiz Vianna, Gabriel S. Macedo, Edenir Inez Palmero, Patricia Ashton-Prolla
Publikováno v:
Genetics and Molecular Biology, Vol 46, Iss 3 suppl 1 (2024)
Abstract The TP53 3’UTR variant rs78378222 A>C has been detected in different tumor types as a somatic alteration that reduces p53 expression through modification of polyadenylation and miRNA regulation. Its prevalence is not yet known in all tumor
Externí odkaz:
https://doaj.org/article/1842083036564d94b5d4456d0ea54ce3
Akademický článek
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Autor:
Marta Lacuna, Alejandro M. Hortal, Claudia Cifuentes, Tania Gonzalo, Miguel Alcoceba, Miguel Bastos, Xosé R. Bustelo, Marcos González, Balbino Alarcón
Publikováno v:
Cells, Vol 12, Iss 23, p 2687 (2023)
Chronic lymphocytic leukemia (CLL) is a hematologic malignancy characterized by progressive accumulation of a rare population of CD5+ B-lymphocytes in peripheral blood, bone marrow, and lymphoid tissues. CLL exhibits remarkable clinical heterogeneity
Externí odkaz:
https://doaj.org/article/841f64528de34f66b0480c1d552f7b9b
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-27 (2021)
Abstract Background The 3′ untranslated region (UTR) plays critical roles in determining the level of gene expression through effects on activities such as mRNA stability and translation. Functional elements within this region have largely been ide
Externí odkaz:
https://doaj.org/article/a05db5009b264eb8844a0af1068e245a
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 22, Iss 1, Pp 1-8 (2021)
Abstract Background Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the expression of the BCR-ABL1 fusion gene. Tyrosine kinase inhibitors (TKI) are used to treat CML, but mutations in the tyrosine kinase domain contr
Externí odkaz:
https://doaj.org/article/6be19435dc74461088dc3a08e7ea59a9
Autor:
Fuxiao Liu, Di Zhao, Ning Wang, Ziwei Li, Yaqin Dong, Shuang Liu, Feng Zhang, Jin Cui, Hailan Meng, Bo Ni, Rong Wei, Hu Shan
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Senecavirus A (SVA) is an emerging virus that belongs to the genus Senecavirus in the family Picornaviridae. Its genome is a positive-sense and single-stranded RNA, containing two untranslated regions (UTRs). The 68-nt-long 3′ UTR is computationall
Externí odkaz:
https://doaj.org/article/27fc0c39efbd4c05a29df8341f8fd6c6