An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

Autor: Siminovitch, Katherine A. ^{25, 26, 27}, Hirschfield, Gideon M. ²⁸, Mason, Andrew ²⁹, Vincent, Catherine ³⁰, Xie, Gang ³¹, Zhang, Jinyi ³², Tang, Ruqi ³³, Ma, Xiong ³³, Li, Zhiqiang ^{34, 35}, Shi, Yongyong ^{34, 35}, Affronti, Andrea ³⁶, Almasio, Piero L. ³⁷, Alvaro, Domenico ³⁸, Andreone, Pietro ³⁹, Andriulli, Angelo ⁴⁰, Azzaroli, Francesco ⁴¹, Battezzati, Pier Maria ⁴², Benedetti, Antonio ⁴³, Bragazzi, MariaConsiglia ⁴⁴, Brunetto, Maurizia ⁴⁵, Bruno, Savino ⁴⁶, Calvaruso, Vincenza ⁴⁷, Cardinale, Vincenzo ⁴⁸, Casella, Giovanni ⁴⁹, Cazzagon, Nora ⁵⁰, Ciaccio, Antonio ⁵¹, Coco, Barbara ⁵², Colli, Agostino ⁵³, Colloredo, Guido ⁵⁴, Colombo, Massimo ⁵⁵, Colombo, Silvia ⁵⁶, Cristoferi, Laura ⁵⁷, Cursaro, Carmela ⁵⁸, Crocè, Lory Saveria ⁵⁹, Crosignani, Andrea ⁶⁰, D’Amato, Daphne ⁶¹, Donato, Francesca ⁶², Elia, Gianfranco ⁶³, Fabris, Luca ⁶⁴, Fagiuoli, Stefano ⁶⁵, Ferrari, Carlo ⁶⁶, Floreani, Annarosa ⁶⁷, Galli, Andrea ⁶⁸, Giannini, Edoardo ⁶⁹, Grattagliano, Ignazio ⁷⁰, Lampertico, Pietro ⁷¹, Lleo, Ana ⁷², Malinverno, Federica ⁷³, Mancuso, Clara ⁷⁴, Marra, Fabio ⁷⁵, Marzioni, Marco ⁷⁶, Massironi, Sara ⁷⁷, Mattalia, Alberto ⁷⁸, Miele, Luca ⁷⁹, Milani, Chiara ⁸⁰, Morini, Lorenzo ⁸¹, Morisco, Filomena ⁸², Muratori, Luigi ⁸³, Muratori, Paolo ⁸⁴, Niro, Grazia A. ⁸⁵, O’Donnell, Sarah ⁸⁶, Picciotto, Antonio ⁸⁷, Portincasa, Piero ⁸⁸, Rigamonti, Cristina ⁸⁹, Ronca, Vincenzo ⁹⁰, Rosina, Floriano ⁹¹, Spinzi, Giancarlo ⁹², Strazzabosco, Mario ⁹³, Tarocchi, Mirko ⁹⁴, Tiribelli, Claudio ⁹⁵, Toniutto, Pierluigi ⁹⁶, Valenti, Luca ⁹⁷, Vinci, Maria ⁹⁸, Zuin, Massimo ⁹⁹, Nakamura, Hitomi ¹⁰⁰, Abiru, Seigo ¹⁰⁰, Nagaoka, Shinya ¹⁰⁰, Komori, Atsumasa ¹⁰⁰, Yatsuhashi, Hiroshi ¹⁰⁰, Ishibashi, Hiromi ¹⁰⁰, Ito, Masahiro ¹⁰⁰, Migita, Kiyoshi ¹⁰¹, Ohira, Hiromasa ¹⁰², Katsushima, Shinji ¹⁰², Naganuma, Atsushi ¹⁰², Sugi, Kazuhiro ¹⁰², Komatsu, Tatsuji ¹⁰², Mannami, Tomohiko ¹⁰², Matsushita, Kouki ¹⁰², Yoshizawa, Kaname ¹⁰², Makita, Fujio ¹⁰², Nikami, Toshiki ¹⁰², Nishimura, Hideo ¹⁰², Kouno, Hiroshi ¹⁰², Kouno, Hirotaka ¹⁰², Ota, Hajime ¹⁰², Komura, Takuya ¹⁰², Nakamura, Yoko ¹⁰², Shimada, Masaaki ¹⁰², Hirashima, Noboru ¹⁰², Komeda, Toshiki ¹⁰², Ario, Keisuke ¹⁰², Nakamuta, Makoto ¹⁰², Yamashita, Tsutomu ¹⁰², Furuta, Kiyoshi ¹⁰², Kikuchi, Masahiro ¹⁰², Naeshiro, Noriaki ¹⁰², Takahashi, Hironao ¹⁰², Mano, Yutaka ¹⁰², Tsunematsu, Seiji ¹⁰², Yabuuchi, Iwao ¹⁰², Shimada, Yusuke ¹⁰², Yamauchi, Kazuhiko ¹⁰², Sugimoto, Rie ¹⁰², Sakai, Hironori ¹⁰², Mita, Eiji ¹⁰², Koda, Masaharu ¹⁰², Tsuruta, Satoru ¹⁰², Kamitsukasa, Hiroshi ¹⁰², Sato, Takeaki ¹⁰², Masaki, Naohiko ¹⁰², Kobata, Tatsuro ¹⁰², Fukushima, Nobuyoshi ¹⁰², Ohara, Yukio ¹⁰², Muro, Toyokichi ¹⁰², Takesaki, Eiichi ¹⁰², Takaki, Hitoshi ¹⁰², Yamamoto, Tetsuo ¹⁰², Kato, Michio ¹⁰², Nagaoki, Yuko ¹⁰², Hayashi, Shigeki ¹⁰², Ishida, Jinya ¹⁰², Watanabe, Yukio ¹⁰², Kobayashi, Masakazu ¹⁰², Koga, Michiaki ¹⁰², Saoshiro, Takeo ¹⁰², Yagura, Michiyasu ¹⁰², Hirata, Keisuke ¹⁰², Tanaka, Atsushu ¹⁰³, Takikawa, Hajime ¹⁰³, Zeniya, Mikio ¹⁰⁴, Abe, Masanori ¹⁰⁵, Onji, Morikazu ¹⁰⁶, Kaneko, Shuichi ¹⁰⁶, Honda, Masao ¹⁰⁶, Arai, Kuniaki ¹⁰⁶, Arinaga-Hino, Teruko ¹⁰⁷, Hashimoto, Etsuko ¹⁰⁸, Taniai, Makiko ¹⁰⁸, Umemura, Takeji ¹⁰⁹, Joshita, Satoru ¹⁰⁹, Nakao, Kazuhiko ¹¹⁰, Ichikawa, Tatsuki ¹¹⁰, Shibata, Hidetaka ¹¹⁰, Yamagiwa, Satoshi ¹¹¹, Seike, Masataka ¹¹², Honda, Koichi ¹¹², Sakisaka, Shotaro ¹¹³, Takeyama, Yasuaki ¹¹³, Harada, Masaru ¹¹⁴, Senju, Michio ¹¹⁴, Yokosuka, Osamu ¹¹⁵, Kanda, Tatsuo ¹¹⁵, Ueno, Yoshiyuki ¹¹⁶, Kikuchi, Kentaro ¹¹⁷, Ebinuma, Hirotoshi ¹¹⁸, Himoto, Takashi ¹¹⁹, Yasunami, Michio ¹²⁰, Murata, Kazumoto ¹²¹, Mizokami, Masashi ¹²¹, Kawata, Kazuhito ¹²², Shimoda, Shinji ¹²³, Miyake, Yasuhiro ¹²⁴, Takaki, Akinobu ¹²⁴, Yamamoto, Kazuhide ¹²⁴, Hirano, Katsuji ¹²⁵, Ichida, Takafumi ¹²⁵, Ido, Akio ¹²⁶, Tsubouchi, Hirohito ¹²⁶, Chayama, Kazuaki ¹²⁷, Harada, Kenichi ¹²⁸, Nakanuma, Yasuni ¹²⁸, Maehara, Yoshihiko ¹²⁹, Taketomi, Akinobu ¹²⁹, Shirabe, Ken ¹²⁹, Soejima, Yuji ¹²⁹, Mori, Akira ¹³⁰, Yagi, Shintaro ¹³⁰, Uemoto, Shinji ¹³⁰, H, Egawa ¹³¹, Tanaka, Tomohiro ¹³², Yamashiki, Noriyo ¹³², Tamura, Sumito ¹³³, Sugawara, Yasuhiro ¹³³, Kokudo, Norihiro ¹³³, Juran, Brian D. ¹³⁴, Atkinson, Elizabeth J. ¹³⁵, Cheung, Angela ¹³⁶, de Andrade, Mariza ¹³⁷, Lazaridis, Konstantinos N. ¹³⁸, Chalasani, Naga ¹³⁹, Luketic, Vel ¹⁴⁰, Odin, Joseph ¹⁴¹, Chopra, Kapil ¹⁴², Baras, Aris ¹⁴³, Horowitz, Julie ¹⁴³, Abecasis, Goncalo ¹⁴³, Cantor, Michael ¹⁴³, Coppola, Giovanni ¹⁴³, Economides, Aris ¹⁴³, Lotta, Luca A. ¹⁴³, Overton, John D. ¹⁴³, Reid, Jeffrey G. ¹⁴³, Shuldiner, Alan ¹⁴³, Beechert, Christina ¹⁴³, Forsythe, Caitlin ¹⁴³, Fuller, Erin D. ¹⁴³, Gu, Zhenhua ¹⁴³, Lattari, Michael ¹⁴³, Lopez, Alexander ¹⁴³, Schleicher, Thomas D. ¹⁴³, Padilla, Maria Sotiropoulos ¹⁴³, Toledo, Karina ¹⁴³, Widom, Louis ¹⁴³, Wolf, Sarah E. ¹⁴³, Pradhan, Manasi ¹⁴³, Manoochehri, Kia ¹⁴³, Ulloa, Ricardo H. ¹⁴³, Bai, Xiaodong ¹⁴³, Balasubramanian, Suganthi ¹⁴³, Barnard, Leland ¹⁴³, Blumenfeld, Andrew ¹⁴³, Eom, Gisu ¹⁴³, Habegger, Lukas ¹⁴³, Hawes, Alicia ¹⁴³, Khalid, Shareef ¹⁴³, Maxwell, Evan K. ¹⁴³, Salerno, William ¹⁴³, Staples, Jeffrey C. ¹⁴³, Jones, Marcus B. ¹⁴³, Mitnaul, Lyndon J. ¹⁴³, Sturgess, Richard ¹⁴⁴, Healey, Christopher ¹⁴⁵, Yeoman, Andrew ¹⁴⁶, Gunasekera, Anton VJ. ¹⁴⁷, Kooner, Paul ¹⁴⁸, Kapur, Kapil ¹⁴⁹, Sathyanarayana, V. ¹⁵⁰, Kallis, Yiannis ¹⁵⁰, Subhani, Javaid ¹⁵¹, Harvey, Rory ¹⁵², McCorry, Roger ¹⁵³, Rooney, Paul ¹⁵³, Ramanaden, David ¹⁵⁴, Evans, Richard ¹⁵⁵, Mathialahan, Thiriloganathan ¹⁵⁶, Gasem, Jaber ¹⁵⁷, Shorrock, Christopher ¹⁵⁸, Bhalme, Mahesh ¹⁵⁹, Southern, Paul ¹⁶⁰, Tibble, Jeremy A. ¹⁶¹, Gorard, David A. ¹⁶², Jones, Susan ¹⁶³, Mells, George ¹⁶⁴, Mulcahy, Victoria ¹⁶⁴, Srivastava, Brijesh ¹⁶⁵, Foxton, Matthew R. ¹⁶⁶, Collins, Carole E. ¹⁶⁷, Elphick, David ¹⁶⁸, Karmo, Mazn ¹⁶⁹, Porras-Perez, Francisco ¹⁷⁰, Mendall, Michael ¹⁷¹, Yapp, Tom ¹⁷², Patel, Minesh ¹⁷³, Ede, Roland ¹⁷⁴, Sayer, Joanne ¹⁷⁵, Jupp, James ¹⁷⁶, Fisher, Neil ¹⁷⁷, Carter, Martyn J. ¹⁷⁸, Koss, Konrad ¹⁷⁹, Shah, Jayshri ¹⁸⁰, Piotrowicz, Andrzej ¹⁸⁰, Scott, Glyn ¹⁸⁰, Grimley, Charles ¹⁸¹, Gooding, Ian R. ¹⁸², Williams, Simon ¹⁸³, Tidbury, Judith ¹⁸⁴, Lim, Guan ¹⁸⁵, Cheent, Kuldeep ¹⁸⁶, Levi, Sass ¹⁸⁷, Mansour, Dina ¹⁸⁸, Beckley, Matilda ¹⁸⁹, Hollywood, Coral ¹⁹⁰, Wong, Terry ¹⁹¹, Marley, Richard ¹⁹¹, Ramage, John ¹⁹², Gordon, Harriet M. ¹⁹³, Ridpath, Jo ¹⁹⁴, Ngatchu, Theodore ¹⁹⁵, Bob Grover, Vijay Paul ¹⁹⁶, Shidrawi, Ray G. ¹⁹⁷, Abouda, George ¹⁹⁸, Corless, L. ¹⁹⁸, Narain, Mark ¹⁹⁹, Rees, Ian ²⁰⁰, Brown, Ashley ²⁰¹, Taylor-Robinson, Simon ²⁰², Wilkins, Joy ²⁰³, Grellier, Leonie ²⁰³, Banim, Paul ²⁰⁴, Das, Debasish ²⁰⁵, Heneghan, Michael A. ²⁰⁶, Curtis, Howard ²⁰⁷, Matthews, Helen C. ²⁰⁸, Mohammed, Faiyaz ²⁰⁹, Aldersley, Mark ²¹⁰, Srirajaskanthan, Raj ²¹¹, Walker, Giles ²¹¹, McNair, Alistair ²¹², Sharif, Amar ²¹³, Sen, Sambit ²¹⁴, Bird, George ²¹⁵, Prince, Martin I. ²¹⁶, Prasad, Geeta ²¹⁷, Kitchen, Paul ²¹⁸, Barnardo, Adrian ²¹⁸, Oza, Chirag ²¹⁹, Sivaramakrishnan, Nurani N. ²²⁰, Gupta, Prakash ²²¹, Shah, Amir ²²², Evans, Chris DJ. ²²³, Saha, Subrata ²²⁴, Pollock, Katharine ²²⁵, Bramley, Peter ²²⁶, Mukhopadhya, Ashis ²²⁷, Barclay, Stephen T. ²²⁸, McDonald, Natasha ²²⁹, Bathgate, Andrew J. ²³⁰, Palmer, Kelvin ²³¹, Dillon, John F. ²³², Rushbrook, Simon M. ²³³, Przemioslo, Robert ²³⁴, McDonald, Chris ²³⁵, Millar, Andrew ²³⁶, Tai, Cheh ²³⁶, Mitchell, Stephen ²³⁷, Metcalf, Jane ²³⁷, Shaukat, Syed ²³⁸, Ninkovic, Mary ²³⁹, Shmueli, Udi ²⁴⁰, Davis, Andrew ²⁴¹, Naqvi, Asifabbas ²⁴², Lee, Tom JW. ²⁴³, Ryder, Stephen ²⁴⁴, Collier, Jane ²⁴⁵, Klass, Howard ²⁴⁶, Cramp, Matthew E. ²⁴⁷, Sharer, Nichols ²⁴⁸, Aspinall, Richard ²⁴⁹, Ghosh, Deb ²⁵⁰, Douds, Andrew C. ²⁵¹, Booth, Jonathan ²⁵², Williams, Earl ²⁵³, Hussaini, Hyder ²⁵⁴, Christie, John ²⁵⁵, Mann, Steven ²⁵⁶, Thorburn, Douglas ²⁵⁷, Marshall, Aileen ²⁵⁷, Patanwala, Imran ²⁵⁸, Ala, Aftab ²⁵⁹, Maltby, Julia ²⁶⁰, Matthew, Ray ²⁶¹, Corbett, Chris ²⁶², Vyas, Sam ²⁶³, Singhal, Saket ²⁶⁴, Gleeson, Dermot ²⁶⁵, Misra, Sharat ²⁶⁶, Butterworth, Jeff ²⁶⁷, George, Keith ²⁶⁸, Harding, Tim ²⁶⁹, Douglass, Andrew ²⁷⁰, Mitchison, Harriet ²⁷¹, Panter, Simon ²⁷², Shearman, Jeremy ²⁷³, Bray, Gary ²⁷⁴, Roberts, Michael ²⁷⁵, Butcher, Graham ²⁷⁵, Forton, Daniel ²⁷⁶, Mahmood, Zahid ²⁷⁷, Cowan, Matthew ²⁷⁸, Das, Debashis ²⁷⁸, Ch’ng, Chin Lye ²⁷⁹, Rahman, Mesbah ²⁸⁰, Whatley, Gregory C.A. ²⁸¹, Wesley, Emma ²⁸², Mandal, Aditya ²⁸³, Jain, Sanjiv ²⁸⁴, Pereira, Stephen P. ²⁸⁵, Wright, Mark ²⁸⁶, Trivedi, Palak ²⁸⁷, Gordon, Fiona H. ²⁸⁸, Unitt, Esther ²⁸⁹, Palejwala, Altaf ²⁹⁰, Austin, Andrew ²⁹¹, Vemala, Vishwaraj ²⁹², Grant, Allister ²⁹², Higham, Andrew D. ²⁹³, Brind, Alison ²⁹⁴, Mathew, Ray ²⁹⁵, Cox, Mark ²⁹⁶, Ramakrishnan, Subramaniam ²⁹⁷, King, Alistair ²⁹⁸, Whalley, Simon ²⁹⁹, Fraser, Jocelyn ³⁰⁰, Thomson, S.J. ³⁰¹, Bell, Andrew ³⁰², Wong, Voi Shim ³⁰³, Kia, Richard ³⁰⁴, Gee, Ian ³⁰⁵, Keld, Richard ³⁰⁶, Ransford, Rupert ³⁰⁷, Gotto, James ³⁰⁸, Millson, Charles ³⁰⁹, Cordell, Heather J. ¹, Fryett, James J. ¹, Ueno, Kazuko ², Darlay, Rebecca ¹, Aiba, Yoshihiro ³, Hitomi, Yuki ⁴, Kawashima, Minae ⁴, Nishida, Nao ⁴, Khor, Seik-Soon ², Gervais, Olivier ^{5, 6}, Kawai, Yosuke ², Nagasaki, Masao ^{5, 6}, Tokunaga, Katsushi ², Gerussi, Alessio ^{12, 13}, Carbone, Marco ^{12, 13}, Asselta, Rosanna ^{14, 15}, Ferreira, Manuel A.R. ¹⁶, Sun, Dylan ¹⁶, Jones, David E. ¹⁷, Flack, Steven ¹⁸, Spicer, Ann ¹⁸, Mulcahy, Victoria L. ¹⁸, Byan, Jinyoung ¹⁹, Han, Younghun ¹⁹, Sandford, Richard N. ¹⁸, Amos, Christopher I. ¹⁹, Seldin, Michael F. ²¹, Invernizzi, Pietro ^{12, 13}, Nakamura, Minoru ^{3, 24}, Mells, George F. ^{18, ∗}

Publikováno v: In Journal of Hepatology September 2021 75(3):572-581

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