Zobrazeno 1 - 10
of 139
pro vyhledávání: '"23andMe Research Team, The"'
Autor:
Mathias Seviiri, Matthew H. Law, Jue-Sheng Ong, Puya Gharahkhani, Pierre Fontanillas, The 23andMe Research Team, Catherine M. Olsen, David C. Whiteman, Stuart MacGregor
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common skin cancers and have genetic overlap. Here, the authors use a multi-trait genetic and phenotypic analysis to reveal susceptibility loci for BCC and SCC, and report an o
Externí odkaz:
https://doaj.org/article/e5e726bee58844e491cc8fdc2767f5c3
Autor:
Kia Joo Puan, Boris San Luis, Nurhashikin Yusof, Dilip Kumar, Anand Kumar Andiappan, Wendy Lee, Samanta Cajic, Dragana Vuckovic, Jing De Chan, Tobias Döllner, Han Wei Hou, Yunxuan Jiang, Chao Tian, the 23andMe Research Team, Erdmann Rapp, Michael Poidinger, De Yun Wang, Nicole Soranzo, Bernett Lee, Olaf Rötzschke
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Puan and San Luis et al. find that FUT6, encoding a fucosyltransferase, is required for the “rolling” behavior of certain white blood cells that enables them to move from blood vessels to tissues. They show that FUT6 deficiency leads to a loss of
Externí odkaz:
https://doaj.org/article/c143d737821c4b528b01c70d7893f2f4
Transcriptome-wide association study identifies new susceptibility genes and pathways for depression
Autor:
Xiaoyan Li, Xi Su, Jiewei Liu, Huijuan Li, Ming Li, the 23andMe Research Team, Wenqiang Li, Xiong-Jian Luo
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Depression is the most prevalent mental disorder with substantial morbidity and mortality. Although genome-wide association studies (GWASs) have identified multiple risk variants for depression, due to the complicated gene regulatory mechani
Externí odkaz:
https://doaj.org/article/9e7a5aa969314fdb8b7ff0556619e225
Autor:
Tianyun Liu, Lichy Han, Mera Tilley, Lovisa Afzelius, Mateusz Maciejewski, Scott Jelinsky, Chao Tian, Matthew McIntyre, the 23andMe Research Team, Nan Bing, Kenneth Hung, Russ B. Altman
Publikováno v:
BMC Gastroenterology, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background Defining clinical phenotypes provides opportunities for new diagnostics and may provide insights into early intervention and disease prevention. There is increasing evidence that patient-derived health data may contain information
Externí odkaz:
https://doaj.org/article/c3ccf1a423d24b01bd3f9a121dd5a241
Autor:
Ong, Jue-Sheng, An, Jiyuan, Law, Matthew H., Nandakumar, Priyanka, Schumacher, Johannes, Gockel, Ines, Bohmer, Anne, Jankowski, Janusz, Palles, Claire, Olsen, Catherine M., Neale, Rachel E., Fitzgerald, Rebecca, Thrift, Aaron P., Vaughan, Thomas L., Buas, Matthew F., Hinds, David A., Gharahkhani, Puya, Kendall, Bradley J., MacGregor, Stuart, 23andMe Research Team, Esophageal cancer consortium
Objective: Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology primarily attributable to its symptom-based definitions. GERD genome-wide association studies (GWASs) have shown strong genetic overlaps with established risk factors suc
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A85814
https://ul.qucosa.de/api/qucosa%3A85814/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A85814/attachment/ATT-0/
Autor:
C. S. Gallagher, N. Mäkinen, H. R. Harris, N. Rahmioglu, O. Uimari, J. P. Cook, N. Shigesi, T. Ferreira, D. R. Velez-Edwards, T. L. Edwards, S. Mortlock, Z. Ruhioglu, F. Day, C. M. Becker, V. Karhunen, H. Martikainen, M.-R. Järvelin, R. M. Cantor, P. M. Ridker, K. L. Terry, J. E. Buring, S. D. Gordon, S. E. Medland, G. W. Montgomery, D. R. Nyholt, D. A. Hinds, J. Y. Tung, the 23andMe Research Team, J. R. B. Perry, P. A. Lind, J. N. Painter, N. G. Martin, A. P. Morris, D. I. Chasman, S. A. Missmer, K. T. Zondervan, C. C. Morton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/0c4b62618c4b49c594faae5d08fef721
Autor:
Yanjun Guo, Pamela M. Rist, Iyas Daghlas, Franco Giulianini, The International Headache Genetics Consortium, The 23andMe Research Team, Tobias Kurth, Daniel I. Chasman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The association between blood pressure (BP) and migraine is poorly understood. Here, the authors explore this relationship using summary-level GWAS data for BP and migraine. Cross-trait meta-analysis reveals shared loci between BP and migraine, while
Externí odkaz:
https://doaj.org/article/092c8891a7dd4e40a00ccb51a6c45afa
Autor:
Ben Brumpton, Eleanor Sanderson, Karl Heilbron, Fernando Pires Hartwig, Sean Harrison, Gunnhild Åberge Vie, Yoonsu Cho, Laura D. Howe, Amanda Hughes, Dorret I. Boomsma, Alexandra Havdahl, John Hopper, Michael Neale, Michel G. Nivard, Nancy L. Pedersen, Chandra A. Reynolds, Elliot M. Tucker-Drob, Andrew Grotzinger, Laurence Howe, Tim Morris, Shuai Li, The Within-family Consortium, The 23andMe Research Team, Adam Auton, Frank Windmeijer, Wei-Min Chen, Johan Håkon Bjørngaard, Kristian Hveem, Cristen Willer, David M. Evans, Jaakko Kaprio, George Davey Smith, Bjørn Olav Åsvold, Gibran Hemani, Neil M. Davies
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Family-based study designs have been applied to resolve confounding by population stratification, dynastic effects and assortative mating in genetic association analyses. Here, Brumpton et al. describe theory and simulations for overcoming such biase
Externí odkaz:
https://doaj.org/article/85accda5604c471488ab1aecb46cd352
Autor:
Karen A. Schlauch, Robert W. Read, Vincent C. Lombardi, Gai Elhanan, William J. Metcalf, Anthony D. Slonim, the 23andMe Research Team, Joseph J. Grzymski
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 2, Pp 645-664 (2020)
The aggregation of Electronic Health Records (EHR) and personalized genetics leads to powerful discoveries relevant to population health. Here we perform genome-wide association studies (GWAS) and accompanying phenome-wide association studies (PheWAS
Externí odkaz:
https://doaj.org/article/ffd8599cc8904bd0a728f91bc5ac97f7
Autor:
C. S. Gallagher, N. Mäkinen, H. R. Harris, N. Rahmioglu, O. Uimari, J. P. Cook, N. Shigesi, T. Ferreira, D. R. Velez-Edwards, T. L. Edwards, S. Mortlock, Z. Ruhioglu, F. Day, C. M. Becker, V. Karhunen, H. Martikainen, M.-R. Järvelin, R. M. Cantor, P. M. Ridker, K. L. Terry, J. E. Buring, S. D. Gordon, S. E. Medland, G. W. Montgomery, D. R. Nyholt, D. A. Hinds, J. Y. Tung, the 23andMe Research Team, J. R. B. Perry, P. A. Lind, J. N. Painter, N. G. Martin, A. P. Morris, D. I. Chasman, S. A. Missmer, K. T. Zondervan, C. C. Morton
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Uterine leiomyomata (UL) or fibroids are neoplasms of the uterine smooth muscle associated with heavy menstrual bleeding and other female reproductive tract morbidity. Here, the authors identify eight previously undescribed genetic loci for UL and fu
Externí odkaz:
https://doaj.org/article/d1a4318550c6403d984ad10ede4120c7