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pro vyhledávání: '"20-HETE"'
Akademický článek
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Autor:
Till Karwen, Katarzyna Kolczynska‐Matysiak, Carina Gross, Mona C Löffler, Mike Friedrich, Angel Loza‐Valdes, Werner Schmitz, Magdalena Wit, Filip Dziaczkowski, Andrei Belykh, Jonathan Trujillo‐Viera, Rabih El‐Merahbi, Carsten Deppermann, Sameena Nawaz, Benoit Hastoy, Agnieszka Demczuk, Manuela Erk, Mariusz R Wieckowski, Patrik Rorsman, Katrin G Heinze, David Stegner, Bernhard Nieswandt, Grzegorz Sumara
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 9, Pp 1-23 (2023)
Abstract Hyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises the possibility that platelets may play a role in the regulation of metabolism. P
Externí odkaz:
https://doaj.org/article/974cd37e10194d4682e8df439ae20f8d
Autor:
Pamela Houeiss, Rachel Njeim, Hani Tamim, Ahmed F. Hamdy, Tanya S. Azar, William S. Azar, Mohamed Noureldein, Youssef H. Zeidan, Awad Rashid, Sami T. Azar, Assaad A. Eid
Publikováno v:
Journal of Advanced Research, Vol 44, Iss , Pp 109-117 (2023)
Introduction: The identification and validation of a non-invasive prognostic marker for early detection of diabetic kidney disease (DKD) can lead to substantial improvement in therapeutic decision-making. Objectives: The main objective of this study
Externí odkaz:
https://doaj.org/article/8ccea6fb8e1842138600c7ef337f8083
Autor:
Dominic A. Siler, Alexa M. Semonche, Ravi Samatham, Jesse J. Liu, Ross P. Martini, Nabil J. Alkayed, Holly E. Hinson, Justin S. Cetas
Publikováno v:
Brain Hemorrhages, Vol 3, Iss 4, Pp 135-142 (2022)
Delayed cerebral ischemia (DCI) is a life-threatening complication of aneurysmal subarachnoid hemorrhage (aSAH). The vasoactive P450 eicosanoids 20-hydroxyeicosatretraenoate (20-HETE) and 14,15-epoxyeicosatrenoate (14,15-EET) are associated with the
Externí odkaz:
https://doaj.org/article/649e36fdb7ca4d6cb14e175935443a7d
Autor:
Iwona Baranowska, Olga Gawrys, Agnieszka Walkowska, Krzysztof H. Olszynski, Luděk Červenka, John R. Falck, Adeniyi M. Adebesin, John D. Imig, Elżbieta Kompanowska-Jezierska
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Numerous studies indicate a significant role for cytochrome P-450-dependent arachidonic acid metabolites in blood pressure regulation, vascular tone, and control of renal function. Epoxyeicosatrienoic acids (EETs) exhibit a spectrum of beneficial eff
Externí odkaz:
https://doaj.org/article/b9fdeecb898742bbaf432726db2343fc
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 783 (2023)
In Dahl salt-sensitive (SS) rats, impaired vascular relaxation can be restored by: (1) minipump infusion of a low (sub-pressor) dose of angiotensin II (ANG II) to restore physiological levels of plasma ANG II, (2) inhibition of 20-HETE production, an
Externí odkaz:
https://doaj.org/article/d8032ec33efa47f0ba2389ffb3712585
Autor:
Batoul Dia, Sahar Alkhansa, Rachel Njeim, Sarah Al Moussawi, Theresa Farhat, Antony Haddad, Mansour E. Riachi, Rashad Nawfal, William S. Azar, Assaad A. Eid
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 965 (2023)
Diabetic kidney disease (DKD) is a serious complication of diabetes, affecting millions of people worldwide. Inflammation and oxidative stress are key contributors to the development and progression of DKD, making them potential targets for therapeut
Externí odkaz:
https://doaj.org/article/d293c3e23089461c8b54c49f5382677e
Autor:
Agnieszka Walkowska, Luděk Červenka, John D. Imig, John R. Falck, Janusz Sadowski, Elżbieta Kompanowska-Jezierska
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Cytochrome P450 (CYP-450) metabolites of arachidonic acid: epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) have established role in regulation of blood pressure (BP) and kidney function. EETs deficiency and increased re
Externí odkaz:
https://doaj.org/article/08d463db50a1474aab1220eec86554a3
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Ezekiel Gonzalez-Fernandez, Daniel Staursky, Kathryn Lucas, Bond V. Nguyen, Man Li, Yedan Liu, Chad Washington, Lique M. Coolen, Fan Fan, Richard J. Roman
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
20-HETE is a potent vasoconstrictor that is implicated in the regulation of blood pressure, cerebral blood flow and neuronal death following ischemia. Numerous human genetic studies have shown that inactivating variants in the cytochrome P450 enzymes
Externí odkaz:
https://doaj.org/article/1ef8b5704a394a9c9240143c37a0137d