Investigation of the Cytotoxic Potencies of substituted dipyrrolo[1,2-a:2',1'-c]pyrazines and substituted pyrrolo[2',1':3',4']pyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-8(9H)-ones

Autor: Azam Barghi lish, Eskandar Kolvari, Alireza Foroumadi, Nadiya Koukabi

Publikováno v: شیمی کاربردی روز, Vol 19, Iss 73, Pp 55-80 (2024)

Cancer is the world's second leading cause of death after cardiovascular diseases. The data reported by the World Health Organization (WHO) about this disease indicates a troubling increase in both prevalence and mortality over the past decade. Conse

Externí odkaz: https://doaj.org/article/1e6768f4139f4b24a9fb012d7df2d89f

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Novel and Selective TLR7 Antagonists among the Imidazo[1,2-a]pyrazines, Imidazo[1,5-a]quinoxalines, and Pyrazolo[1,5-a]quinoxalines Series

Autor: Bou Karroum, Nour, Moarbess, Georges, Guichou, Jean-François, Bonnet, Pierre-Antoine, Patinote, Cindy, Bouharoun-Tayoun, Hasnaa, Chamat, Soulaima, Cuq, Pierre, Diab-Assaf, Mona, Kassab, Issam, Deleuze-Masquéfa, Carine

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (15), pp.7015-7031. ⟨10.1021/acs.jmedchem.9b00411⟩

International audience; The Toll-like receptors (TLRs) 7 and 8 play an important role in the immune system activation, and their agonists may therefore serve as promising candidate vaccine adjuvants. However, the chronic immune activation by excessiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7d21e763e82d77c6cda759f7a8dd8ae6
https://hal.archives-ouvertes.fr/hal-02389036

Synthèse et développement de nouvelles molécules hétérocycliques tricycliques : étude de leurs propriétés immunomodulatrices

Autor: Bou Karroum, Nour

Les récepteurs Toll-like 7 et 8 jouent un rôle important dans l’activation de la réponse immunitaire innée et adaptative. Leur stimulation conduit à la production des cytokines pro-inflammatoires et d’interférons de type I. L’imiquimod et

Externí odkaz: http://www.theses.fr/2018MONTT014/document

A Facile Synthesis of Novel Herbicidal 1-Phenyl-piperazine-2,6-diones

Autor: Chao Wu, Chi-Tung Hsu, Hua-Zheng Yang, Bin Li, Zhen-Long Liu, Dong Xiang

Publikováno v: Molecules, Vol 10, Iss 9, Pp 1119-1125 (2005)
Molecules
Volume 10
Issue 9
Pages 1119-1125
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

Novel 1-phenyl-piperazine-2,6-diones were prepared by a new facile synthetic route using methyl N-substituted iminomonoacetate as starting material. The structures of these compounds were established by (1)H-NMR, (13)C-NMR and GC/MS. 2-(4-Chloro-5-cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e8af7459d50780f108c665960989d6
http://www.mdpi.com/1420-3049/10/9/1119/