The isopeptidase USP2a protects human prostate cancer from apoptosis

Autor: Carmen Priolo, 1, 5, 7 Dan Tang, 1 Mohan Brahamandan, 1 Barbara Benassi, 5 Ewa Sicinska, 1 Shuji Ogino, 2 Antonella Farsetti, 6 Alessandro Porrello, 4, 5 Stephen Finn, 1 Johann Zimmermann, 3 Phillip Febbo, Massimo Loda1, 2

Publikováno v: Cancer research (Chic. Ill.) 66 (2006): 8625–8632.
info:cnr-pdr/source/autori:Carmen Priolo,1,5,7 Dan Tang,1 Mohan Brahamandan,1 Barbara Benassi,1,5 Ewa Sicinska,1 Shuji Ogino,1,2 Antonella Farsetti,5,6 Alessandro Porrello,4,5 Stephen Finn,1 Johann Zimmermann,3 Phillip Febbo,4 and Massimo Loda1,2/titolo:The isopeptidase USP2a protects human prostate cancer from apoptosis/doi:/rivista:Cancer research (Chic. Ill.)/anno:2006/pagina_da:8625/pagina_a:8632/intervallo_pagine:8625–8632/volume:66

Deubiquitinating enzymes can prevent the destruction of protein substrates prior to proteasomal degradation. The ubiquitin-specific protease 2a (USP2a)deubiquitinat es the antiapoptotic proteins Fatty Acid Synthase and Mdm2. Here, we show that when U

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http://www.cnr.it/prodotto/i/4842