Zobrazeno 1 - 10
of 50
pro vyhledávání: '"2'3' dideoxynucleoside"'
Publikováno v:
Chinese Chemical Letters. 25:427-430
The triphosphates and homodinucleotides of AZT and d4T have been efficiently synthesized from the corresponding nucleoside 5′- H -phosphonate monoesters via the reactive pyridinium phosphoramidate intermediates.
Publikováno v:
Tetrahedron. 65:2959-2965
A series of 4′-aryl-2′,3′-dideoxynucleoside analogues were synthesized from optically pure 5-oxo-2-aryl-tetrahydrofuran-2-carboxylic acids up to 62% overall yield. 5-Oxo-2-aryl-tetrahydrofuran-2-carboxylic acids were obtained from 2-hydroxy-3-a
Autor:
Marit Ilves, Anne Paju, Tiiu Kailas, Margus Lopp, Artur Jõgi, Aleksander-Mati Müürisepp, Tõnis Pehk
Publikováno v:
Tetrahedron: Asymmetry. 19:628-634
Both enantiomers of the key intermediate, 2-benzyl-5-oxo-tetrahydro-furan-2-carboxylic acid were obtained by asymmetric oxidation of 3-benzyl-2-hydroxy-2-cyclopenten-1-one with an ee ⩾96%, using the tartaric ester/Ti(O i Pr) 4 / t -BuOOH complex, a
Autor:
Michal Sobkowski, Krystian Kolodziej, Jacek Stawinski, Andrzej Piasek, Jerzy Boryski, Adam Kraszewski, Aleksandra Dabrowska, Andrzej Lipniacki, Joanna Romanowska
Publikováno v:
European journal of medicinal chemistry. 100
Recently, AZT (N-pyridyl)phosphoramidates were reported as a new type of potential anti-HIV therapeutics. In continuation of that work, here we present new (N-heteroaryl)phosphoramidate derivatives of antiviral 2′,3′-dideoxynucleosides containing
Autor:
Elena V. Zhernosek, A. I. Zinchenko, Sergei V. Kvach, Ludmilla A. Eroshevskaya, Elena N. Kalinichenko
Publikováno v:
Chemistry of Natural Compounds. 42:208-211
Previously undescribed conjugates of 2′,3′-dideoxyuridine-5′-monophosphate-(L)-methoxytryptophylphosphoramidate (5) and 2′,3′-dideoxycytidine-5′-monophosphate-(L)-methoxytryptophylphosphoramidate (7) were isolated by a chemical enzymatic
Autor:
Nicholas A. Boyle, Jennifer L. Brooks, Patrick Fagan, John S. Lambert, Marija Prhavc, P. Dan Cook
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 24:1651-1664
Nucleoside reverse transcriptase inhibitors (NRTIs) are prodrugs which require three intracellular phosphorylation steps to yield their corresponding, biologically active, nucleoside triphosphate. In order to circumvent this often inefficient phospho
Publikováno v:
Synthetic Communications. 34:159-170
Novel 1,3‐dioxane C‐nucleoside analogues of tiazofurin 2‐[2‐(hydroxymethyl)‐1,3‐dioxan‐5‐methyl‐5‐yl] 1,3‐thiazole‐4‐carboxamide, 2‐[2‐(hydroxymethyl)‐1,3‐dioxan‐5‐ethyl‐5‐yl] 1,3‐thiazole‐4‐carbox...
Publikováno v:
Organic Letters. 4:3251-3254
[reaction: see text] A new method for the synthesis of 2',3'-dideoxynucleoside analogues has been developed. An electrochemical activation of 2-substituted furans is followed by the coupling with a pyrimidine or purine base. This gives planar furyl n
Autor:
Ranjith Pathinara, Erik De Clercq, Stefano Aquaro, Carlo Federico Perno, Dominique Cahard, Raffaele Caliò, Jan Balzarini, Orson Wedgwood, Christopher Yarnold, Christopher Mcguigan
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:173-177
The anti-human immunodeficiency virus (HIV) activity of aryloxyphosphoramidate protides of a number of anti-HIV nucleoside analogues was assessed in resting primary monocyte-macrophages (M/M). While 2′,3′-dideoxythymidine (d4T), 2′,3′-dideoxy
Autor:
Antonietta R. Belmonte, Kazushige Nagai, Horacio Salomón, Tarek S. Mansour, Mark A. Wainberg, Nathalie Richard
Publikováno v:
Nucleosides and Nucleotides. 16:1235-1240
We have selected for resistance against a novel compound, (+) dOTFC, using HIV-1 tissue culture replication assays. A novel D67G (asp gly) mutation in HIV-1 reverse transcriptase has been identified that confers about 5-fold resistance to this drug b