Zobrazeno 1 - 10
of 302
pro vyhledávání: '"2',3'-Cyclic-nucleotide 3'-phosphodiesterase"'
Autor:
James E. Goldman, Alice Tang, Michelle L. Olsen, Natasha L. Pacheco, Jiangtao Li, Daniel Flint, Brett S. Phinney, Anthony W. Herren, Fatima Khan, Michael R. Heaven
Publikováno v:
Molecular & cellular proteomics : MCP, vol 21, iss 1
Molecular & Cellular Proteomics : MCP
Molecular & Cellular Proteomics : MCP
Alexander disease (AxD) is a rare and fatal neurodegenerative disorder caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). In this report, a mouse model of AxD (GFAPTg;Gfap+/R236H) was analyzed that contains a heterozygou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27db73f1a1ae5cb5705d0a860adbda89
https://hdl.handle.net/10919/111277
https://hdl.handle.net/10919/111277
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10806, p 10806 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Heart failure is the end-stage of all cardiovascular diseases with a ~25% 5-year survival rate, and insufficient mitochondrial energy production to meet myocardial demand is the hallmark of heart failure. Mitochondrial components involved in the regu
Publikováno v:
Cell Proliferation
Objectives Fibrosis is a complex process involved in multiple diseases that result in organ injury and failure. Cataract, one common form of ocular fibrosis, is a main cause of blindness worldwide, and surgery may be the only cure. In this regard, ep
Publikováno v:
Brain Sciences
Brain Sciences, Vol 11, Iss 588, p 588 (2021)
Brain Sciences, Vol 11, Iss 588, p 588 (2021)
The enzyme, 2′-3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) has been known for over fifty years. Nevertheless, the roles this membrane-bound enzyme play have yet to be described completely. Recently, there has been renewed interest in the
Autor:
Junko Sato, Minoru Tsuchitani, Yoshiyasu Kobayashi, Yuki Tomonari, Takeshi Kanno, Tetsuro Kurotaki, Naoaki Yamada
Publikováno v:
The Journal of Veterinary Medical Science
In a previous study, we showed that 2', 3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNPase) expression is induced in different temporal patterns in the cerebrum, cerebellum and medulla oblongata of hexachlorophene (HCP) and cuprizone (CPZ) treated rat
Autor:
Hwan Tae Park, Young Hye Kim, Hyeran Kim, Young Rae Jo, Kyung Eun Lee, Yoon Kyung Shin, Da Kyeong Park, Hana Go, Min-Young Song, Yuna Oh, Sung Joong Lee, Juyeon Jo, Sang-Myung Cheon, So Young Jang, Hyun Kyoung Lee
Publikováno v:
The FASEB Journal. 35
Studies of neuroglial interaction largely depend on cell-specific gene knockout (KO) experiments using Cre recombinase. However, genes known as glial-specific genes have recently been reported to be expressed in neuroglial stem cells, leading to the
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 3217, p 3217 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 3217, p 3217 (2020)
2′,3′-cyclic nucleotide-3′-phosphodiesterase (CNPase) is a myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2’,3’-cyclic nucleotides to 2’-nucleotides. However, its presence is also found in unmyelinated cells and
Publikováno v:
Neurochemical Journal. 12:33-40
Melatonin (N-acetyl-5-methoxytryptamine), a neuroendocrine hormone of the pineal gland, participates in the modulation of the mitochondrial nonspecific pore (mitochondrial permeability transition pore, mPTP). According to the results we obtained, pro
Autor:
Vladimir S. Akatov, Yulia Baburina, Linda Sotnikova, Olga Krestinina, Irina Odinokova, T. S. Azarashvili
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3499 (2018)
International Journal of Molecular Sciences
Volume 19
Issue 11
International Journal of Molecular Sciences
Volume 19
Issue 11
Calcium as a secondary messenger regulates the phosphorylation of several membrane-bound proteins in brain and liver mitochondria. Regulation of the activity of different protein kinases and phosphatases by Ca2+ occurs through its binding with calmod
Autor:
Arne Raasakka, Matti Myllykoski, Gopinath Muruganandam, Andrew E. Torda, Petri Kursula, Leonie Seidel
Publikováno v:
Brain Research. 1641:64-78
2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is an abundant membrane-associated enzyme within the vertebrate myelin sheath. While the physiological function of CNPase still remains to be characterized in detail, it is known - in addition to