Novel Insights Into Epigenetic Reprogramming and Destabilization of Pericentromeric Heterochromatin in Cancer

Autor: Morten Frier Gjerstorff

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Pericentromeric heterochromatin is maintained in a condensed structure by repressive epigenetic control mechanisms and perturbation of these may cause diseases. The chromosome 1q12 region harbors the largest pericentromeric heterochromatin domain in

Externí odkaz: https://doaj.org/article/3922798980804c8e90aecd88291a6b3b

Copy Number Variation of Satellite III (1q12) in Patients With Schizophrenia

Autor: Elizaveta S. Ershova, Oksana N. Agafonova, Natalia V. Zakharova, Lidia V. Bravve, Elizaveta M. Jestkova, Vera E. Golimbet, Tatiana V. Lezheiko, Anna Y. Morozova, Andrey V. Martynov, Roman V. Veiko, Pavel E. Umriukhin, Georgiy P. Kostyuk, Sergey I. Kutsev, Natalia N. Veiko, Svetlana V. Kostyuk

Publikováno v: Frontiers in Genetics, Vol 10 (2019)

Introduction: It was shown that copy number variations (CNVs) of human satellite III (1q12) fragment (f-SatIII) reflects the human cells response to stress of different nature and intensity. Patients with schizophrenia (SZ) experience chronic stress.

Externí odkaz: https://doaj.org/article/07362bddecd548d8b16e69a198adbc30

Gain/Amplification of Chromosome Arm 1q21 in Multiple Myeloma

Autor: Ichiro Hanamura

Publikováno v: Cancers, Vol 13, Iss 256, p 256 (2021)
Cancers

Simple Summary Multiple myeloma (MM), a plasma cell neoplasm, is an incurable hematological malignancy. Gain/amplification of chromosome arm 1q21 (1q21+) is the most common adverse genomic abnormality associated with disease progression and drug resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f97295538ed04e8a27f3928e3f7b55
https://www.mdpi.com/2072-6694/13/2/256

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1q12 chromosome translocations form aberrant heterochromatic foci associated with changes in nuclear architecture and gene expression in B cell lymphoma

Autor: Stéphanie Chauvelier, Alexandra Debernardi, Katia Delaval, Robert Feil, Remy Gressin, Alexandra Fournier, Martin Figeac, Alicia Lajmanovich, Aurélie Granjon, Christine Lefebvre, Mary Callanan, Yves Usson, Claire Vourc'h, Kassambara Alboukadel, Sophie Rousseaux, John De Vos, Alexei Grichine, Juliana Bruder Ribeyron, Florence de Fraipont, Jean-Pierre Kerckaert, Leila Barki, Thierry Bonnefoix, Anne McLeer-Florin, Saadi Khochbin, Sieme Hamaidia, Samuel Duley, Dominique Leroux

Publikováno v: EMBO Molecular Medicine
EMBO Molecular Medicine, 2010, 2 (5), pp.159-71. ⟨10.1002/emmm.201000067⟩
EMBO Molecular Medicine, Wiley Open Access, 2010, 2 (5), pp.159-71. 〈10.1002/emmm.201000067〉
EMBO Molecular Medicine, Wiley Open Access, 2010, 2 (5), pp.159-71. ⟨10.1002/emmm.201000067⟩

International audience; Epigenetic perturbations are increasingly described in cancer cells where they are thought to contribute to deregulated gene expression and genome instability. Here, we report the first evidence that a distinct category of chr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d8fdf9fd716543965ddc000df49f61
https://www.hal.inserm.fr/inserm-00482580/document