IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression

Autor: Sven Hagemann, Danny Misiak, Jessica L. Bell, Tommy Fuchs, Marcell I. Lederer, Nadine Bley, Monika Hämmerle, Ehab Ghazy, Wolfgang Sippl, Johannes H. Schulte, Stefan Hüttelmaier

Publikováno v: Molecular Cancer, Vol 22, Iss 1, Pp 1-23 (2023)

Abstract Background Neuroblastoma is the most common solid tumor in infants accounting for approximately 15% of all cancer-related deaths. Over 50% of high-risk neuroblastoma relapse, emphasizing the need of novel drug targets and therapeutic strateg

Externí odkaz: https://doaj.org/article/ca683df65b6941eab6938839b5d6ab26

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Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers

Autor: Mauro Tutino, Raquel Granell, John A. Curtin, Sadia Haider, Sara Fontanella, Clare S. Murray, Graham Roberts, S. Hasan Arshad, Stephen Turner, Andrew P. Morris, Adnan Custovic, Angela Simpson

Publikováno v: STELAR/UNICORN investigators 2023, ' Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers ', The Journal of allergy and clinical immunology, vol. 151, no. 2, pp. 423-430 . https://doi.org/10.1016/j.jaci.2022.10.012
Tutino, M, Granell, R, Curtin, J A, Haider, S, Fontanella, S, Murray, C S, Roberts, G, Arshad, S H, Turner, S, Morris, A P & Custovic, A & Simpson, A 2022, ' Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers ', Journal of Allergy and Clinical Immunology . https://doi.org/10.1016/j.jaci.2022.10.012
STELAR/UNICORN investigators 2022, ' Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers ', Journal of Allergy and Clinical Immunology . https://doi.org/10.1016/j.jaci.2022.10.012

BackgroundAsthma-associated single nucleotide polymorphisms from large genome-wide association studies only explain a fraction of genetic heritability. Likely causes of the missing heritability include broad phenotype definitions and gene-environment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c092f09e1529356920bc8a80fea871b5
https://doi.org/10.1016/j.jaci.2022.10.012

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Prognostic significance of isochromosome 17q in hematologic malignancies

Autor: Dorota Koczkodaj, Monika Podhorecka, Justyna Muzyka-Kasietczuk, Sylwia Chocholska

Publikováno v: Oncotarget

Isochromosome 17q [i(17q)] with its two identical long arms is formed by duplication of the q arm and loss of the short p arm. The breakpoint in chromosome 17 that allows the formation of this isochromosome is located at 17p11.2, and the ~240 kb regi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf1bc2c6a56b23d8c926c14e0711727
http://europepmc.org/articles/PMC8021031