MYC sensitises cells to apoptosis by driving energetic demand

Autor: Joy Edwards-Hicks, Huizhong Su, Maurizio Mangolini, Kubra K. Yoneten, Jimi Wills, Giovanny Rodriguez-Blanco, Christine Young, Kevin Cho, Heather Barker, Morwenna Muir, Ania Naila Guerrieri, Xue-Feng Li, Rachel White, Piotr Manasterski, Elena Mandrou, Karen Wills, Jingyu Chen, Emily Abraham, Kianoosh Sateri, Bin-Zhi Qian, Peter Bankhead, Mark Arends, Noor Gammoh, Alex von Kriegsheim, Gary J. Patti, Andrew H. Sims, Juan Carlos Acosta, Valerie Brunton, Kamil R. Kranc, Maria Christophorou, Erika L. Pearce, Ingo Ringshausen, Andrew J. Finch

Publikováno v: Edwards-Hicks, J, Su, H, Mangolini, M, Karaosmanoglu Yoneten, K, Wills, J, Rodriguez Blanco, G, Young, C, Cho, K, Barker, H, Muir, M, Guerrieri, A, Li, X-F, White, R, Manasterski, P, Mandrou, E, Wills, K, Chen, J, Abraham, E, Sateri, K, Qian, B-Z, Bankhead, P, Arends, M J, Gammoh, N, von Kriegsheim, A, Patti, G, Sims, A H, Acosta, J C, Brunton, V G, Kranc, K R, Christophorou, M A, Pearce, E, Ringshausen, I & Finch, A J 2022, ' Myc sensitises cells to apoptosis by driving energetic demand ', Nature Communications . https://doi.org/10.1038/s41467-022-32368-z
Nature Communications

Funder: RCUK | Medical Research Council (MRC); doi: https://doi.org/10.13039/501100000265
Funder: Cancer Research UK (CRUK); doi: https://doi.org/10.13039/501100000289
Funder: Wellcome Trust (Wellcome); doi: https://doi.org/10.13039/1000044

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa98506243d4bfe6126ddc3df7039eb
https://www.repository.cam.ac.uk/handle/1810/340915

iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2

Autor: Dulloo, Iqbal, Atakpa-Adaji, Peace, Yeh, Yi-Chun, Levet, Cl��mence, Muliyil, Sonia, Lu, Fangfang, Taylor, Colin, Freeman, Matthew

Publikováno v: Nature Communications. 13

Funder: Human Frontier Science Program (HFSP); doi: https://doi.org/10.13039/501100000854
Funder: Chinese Scholarship Council - University of Oxford Scholarship: 201806240008
The folding capacity of membrane and secretory proteins in the en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4748ec181048a781c25eb3eb7325e9
https://doi.org/10.1038/s41467-022-28930-4

Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2

Autor: Novoyatleva, Tatyana, Rai, Nabham, Kojonazarov, Baktybek, Veeroju, Swathi, Ben-Batalla, Isabel, Caruso, Paola, Shihan, Mazen, Presser, Nadine, Götz, Elsa, Lepper, Carina, Herpel, Sebastian, Manaud, Grégoire, Perros, Frédéric, Gall, Henning, Ghofrani, Hossein Ardeschir, Weissmann, Norbert, Grimminger, Friedrich, Wharton, John, Wilkins, Martin, Upton, Paul D, Loges, Sonja, Morrell, Nicholas W, Seeger, Werner, Schermuly, Ralph T

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Communications Biology

Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e., monocrotaline and Su5416/hypoxia treated r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55808d09bf69bcabbb77ddde5652041c

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Autor: Stephan Spahn, Florian Müller, Revant Gupta, Dominik Pfister, Kornelius Schulze, Pierre Bedossa, Eleni Kotsiliti, Lars Zender, Mathias Heikenwalder, Nicolás Gonzalo Núñez, Peter Schirmacher, Axel Schulz, Jan Kosla, Adrian T. Billeter, Thomas Engleitner, Aleksandra Deczkowska, Danijela Heide, Donato Inverso, Susanne Roth, Olivier Govaere, Carla Montironi, Martha M. Kirstein, Dan G. Duda, Antonio D'Alessio, Jörn M. Schattenberg, Ekaterina Friebel, Tiziana Pressiani, F. Hucke, Jörg Trojan, Michael Bitzer, Suhail Yousuf, Bernhard Scheiner, Marina Ruiz de Galarreta, Markus Peck-Radosavljevic, Michael Allison, Nuh N. Rahbari, Simon Cockell, Brinda Emu, Ahmed Kaseb, David J. Pinato, Matthias P. Ebert, Joachim C. Mertens, Jean-François Dufour, Fabian Rössler, Achim Weber, Katharina Wolter, Thomas Decaens, Amaia Lujambio, Anja Moncsek, Daniela Lenggenhager, Katharina Pomej, Nisar P. Malek, Fabian Finkelmeier, Elisabetta Bugianesi, Valentina Leone, Ann K. Daly, Michael Dudek, Manfred Claassen, Zuzana Macek Jilkova, Henning Wege, Florian Castet, Marta Szydlowska, Beat P. Müller-Stich, Ramy Younes, Nicola Personeni, Philipp K. Haber, Marco Bueter, Manfred Jugold, Andrea Schietinger, Hiroto Kikuchi, Ido Amit, Sandra Koch, Dina Tiniakos, Ana Teijeiro, Jan-Philipp Mallm, Josep M. Llovet, Indrabahadur Singh, Percy A. Knolle, Sara De Dosso, Roland Rad, Arndt Vogel, Henrik E. Mei, Burkhard Becher, Nabil Djouder, Tom Luedde, Felix Meissner, Oliver Waidmann, Parice N. Marche, Viktor Umansky, Hellmut G. Augustin, Thomas U. Marron, Matthias Pinter, Mengjie Qiu, Arndt Weinmann, Ankit Sinha, Kristian Unger, Assaf Weiner, Vlad Ratziu, Quentin M. Anstee, Kristin Stirm, Yi Hsiang Huang, Alexander Siebenhüner, Fabian Kütting, Lorenza Rimassa, Dirk Waldschmidt, Masatoshi Kudo, Marc Ringelhan, Michele Vacca, Roser Pinyol, Fabio Marra

Publikováno v: Nature
Nature, Nature Publishing Group, 2021, 592 (7854), pp.450-456. ⟨10.1038/s41586-021-03362-0⟩
Pfister, Dominik; Núñez, Nicolás Gonzalo; Pinyol, Roser; Govaere, Olivier; Pinter, Matthias; Szydlowska, Marta; Gupta, Revant; Qiu, Mengjie; Deczkowska, Aleksandra; Weiner, Assaf; Müller, Florian; Sinha, Ankit; Friebel, Ekaterina; Engleitner, Thomas; Lenggenhager, Daniela; Moncsek, Anja; Heide, Danijela; Stirm, Kristin; Kosla, Jan; Kotsiliti, Eleni; ... (2021). NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature, 592(7854), pp. 450-456. Springer Nature 10.1038/s41586-021-03362-0
Nature, 2021, 592 (7854), pp.450-456. ⟨10.1038/s41586-021-03362-0⟩

Hepatocellular carcinoma (HCC) can have viral or non-viral causes1–5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification of patients for optimal r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a22b0e0b30f953f3685c09c1fe9c994
https://www.hal.inserm.fr/inserm-03348110

Phosphorylation by Aurora B kinase regulates caspase-2 activity and function

Autor: Luisa Capalbo, Jarrod J. Sandow, Yoon Lim, James M. Murphy, Loretta Dorstyn, Andrew I. Webb, Dylan De Bellis, Sharad Kumar, Pier Paolo D'Avino

Publikováno v: Cell Death and Differentiation

Mitotic catastrophe (MC) is an important oncosuppressive mechanism that serves to eliminate cells that become polyploid or aneuploidy due to aberrant mitosis. Previous studies have demonstrated that the activation and catalytic function of caspase-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa194ad98eaa6d6f201a8e83572f39da
https://www.repository.cam.ac.uk/handle/1810/326919