Zobrazeno 1 - 10
of 52
pro vyhledávání: '"13/109"'
Autor:
Ludek Koreny, Brandon N. Mercado-Saavedra, Christen M. Klinger, Konstantin Barylyuk, Simon Butterworth, Jennifer Hirst, Yolanda Rivera-Cuevas, Nathan R. Zaccai, Victoria J. C. Holzer, Andreas Klingl, Joel B. Dacks, Vern B. Carruthers, Margaret S. Robinson, Simon Gras, Ross F. Waller
Acknowledgements: This work was supported by the Wellcome Trust, United Kingdom, Investigator award 214298/Z/18/Z to R.F.W., a Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) grant 464878930 to S.G., and a DFG Equipment grant INST 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d2d5773dfd5d2a6bf8621c64d002b9
Autor:
Zecchini, Vincent, Paupe, Vincent, Herranz-Montoya, Irene, Janssen, Joëlle, Wortel, Inge MN, Morris, Jordan L, Ferguson, Ashley, Chowdury, Suvagata Roy, Segarra-Mondejar, Marc, Costa, Ana SH, Pereira, Gonçalo C, Tronci, Laura, Young, Timothy, Nikitopoulou, Efterpi, Yang, Ming, Bihary, Dóra, Caicci, Federico, Nagashima, Shun, Speed, Alyson, Bokea, Kalliopi, Baig, Zara, Samarajiwa, Shamith, Tran, Maxine, Mitchell, Thomas, Johnson, Mark, Prudent, Julien, Frezza, Christian
Publikováno v:
Nature, 615, 499-506
Nature 615 (2023) 7952
Nature, 615, pp. 499-506
Nature, 615(7952), 499-506
Nature 615 (2023) 7952
Nature, 615, pp. 499-506
Nature, 615(7952), 499-506
Acknowledgements: This work was supported by the Medical Research Council to J.P. (MC_UU_00015/7 and MC_UU_00028/5) and C.F. (MRC_MC_UU_12022/6). V.P. was supported by the European Union’s Horizon 2020 research and innovation programme (MITODYN-749
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443dcaca27eda909f097910972a5c06d
http://hdl.handle.net/2066/290645
http://hdl.handle.net/2066/290645
Autor:
Shan Tang, Adam T. Beattie, Lucie Kafkova, Gianluca Petris, Nicolas Huguenin-Dezot, Marc Fiedler, Matthew Freeman, Jason W. Chin
Publikováno v:
Nature
Hydrolase enzymes, including proteases, are encoded by 2–3% of the genes in the human genome and 14% of these enzymes are active drug targets1. However, the activities and substrate specificities of many proteases—especially those embedded in mem
Publikováno v:
Nature Communications, 13
MicroRNAs (miRNAs) modulate physiological responses by repressing the expression of gene networks. We found that global deletion of microRNA-7 (miR-7), the most enriched miRNA in the hypothalamus, causes obesity in mice. Targeted deletion of miR-7 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc6f25cf8c49cca849549d6f21cbfc6
https://www.repository.cam.ac.uk/handle/1810/341547
https://www.repository.cam.ac.uk/handle/1810/341547
Autor:
Amadei, Gianluca, Handford, Charlotte E., Qiu, Chengxiang, De Jonghe, Joachim, Greenfeld, Hannah, Tran, Martin, Martin, Beth K., Chen, Dong-Yuan, Aguilera-Castrejon, Alejandro, Hanna, Jacob H., Elowitz, Michael B., Hollfelder, Florian, Shendure, Jay, Glover, David M., Zernicka-Goetz, Magdalena
Embryonic stem (ES) cells can undergo many aspects of mammalian embryogenesis in vitro1–5, but their developmental potential is substantially extended by interactions with extraembryonic stem cells, including trophoblast stem (TS) cells, extraembry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035ef1fefe5868fd725c507c65932c55
https://www.repository.cam.ac.uk/handle/1810/341688
https://www.repository.cam.ac.uk/handle/1810/341688
Autor:
Yu Yuan, Dawid Jaślan, Taufiq Rahman, Stephen R. Bolsover, Vikas Arige, Larry E. Wagner, Carla Abrahamian, Rachel Tang, Marco Keller, Jonas Hartmann, Anna S. Rosato, Eva-Maria Weiden, Franz Bracher, David I. Yule, Christian Grimm, Sandip Patel
Two-pore channels are endo-lysosomal cation channels with malleable selectivity filters that drive endocytic ion flux and membrane traffic. Here we show that TPC2 can differentially regulate its cation permeability when co-activated by its endogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71859e25e0ebfbb43c889752e0fbccca
https://www.repository.cam.ac.uk/handle/1810/339751
https://www.repository.cam.ac.uk/handle/1810/339751
Autor:
Ariella Weinberg-Shukron, Raz Ben-Yair, Nozomi Takahashi, Marko Dunjić, Alon Shtrikman, Carol A. Edwards, Anne C. Ferguson-Smith, Yonatan Stelzer
Funder: Minerva Foundation (Minerva Stiftung); doi: https://doi.org/10.13039/501100001658
Funder: Israel Cancer Research Fund (Israel Cancer Research Fund, Inc.); doi: https://doi.org/10.13039/100001698
Funder: Moross Integrated Cancer Cent
Funder: Israel Cancer Research Fund (Israel Cancer Research Fund, Inc.); doi: https://doi.org/10.13039/100001698
Funder: Moross Integrated Cancer Cent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca98933e9f925e9ab396fb87ca3bcae3
Publikováno v:
Nature communications. 13(1)
The unprecedented emergence and spread of SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, underscores the need for diagnostic and therapeutic technologies that can be rapidly tailored to novel threats. Here, we show that site-speci
Autor:
Steurer, Barbara, Janssens, Roel C, Geijer, Marit E, Aprile-Garcia, Fernando, Geverts, Bart, Theil, Arjan F, Hummel, Barbara, Van Royen, Martin E, Evers, Bastiaan, Bernards, René, Houtsmuller, Adriaan B, Sawarkar, Ritwick, Marteijn, Jurgen
Funder: Oncode Institute
The precise regulation of RNA Polymerase II (Pol II) transcription after genotoxic stress is crucial for proper execution of the DNA damage-induced stress response. While stalling of Pol II on transcription-blocking lesi
The precise regulation of RNA Polymerase II (Pol II) transcription after genotoxic stress is crucial for proper execution of the DNA damage-induced stress response. While stalling of Pol II on transcription-blocking lesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834a9b8389b04eed753b66e9255fd0fa
https://www.repository.cam.ac.uk/handle/1810/339497
https://www.repository.cam.ac.uk/handle/1810/339497
Autor:
L. F. L. Wilson, T. Dendooven, S. W. Hardwick, A. Echevarría-Poza, T. Tryfona, K. B. R. M. Krogh, D. Y. Chirgadze, B. F. Luisi, D. T. Logan, K. Mani, P. Dupree
Funder: University of Cambridge; doi: https://doi.org/10.13039/501100000735
Funder: AstraZeneca; doi: https://doi.org/10.13039/100004325
Funder: RCUK | Biotechnology and Biological Sciences Research Council (BBSRC); doi: https://doi.org/10.
Funder: AstraZeneca; doi: https://doi.org/10.13039/100004325
Funder: RCUK | Biotechnology and Biological Sciences Research Council (BBSRC); doi: https://doi.org/10.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411486da94d4cb16bd50cc82cd3b0560
https://www.repository.cam.ac.uk/handle/1810/338975
https://www.repository.cam.ac.uk/handle/1810/338975