Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors

Autor: Mélina Blairvacq, Olivier Lozach, Christophe Labrière, Laurent Meijer, Catherine Guillou

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2016, 124, pp.920-934. ⟨10.1016/j.ejmech.2016.08.069⟩
European Journal of Medicinal Chemistry, 2016, 124, pp.920-934. ⟨10.1016/j.ejmech.2016.08.069⟩

International audience; Starting from a known compound, identified as the first inhibitor of the kinesin MKLP-2 and named Paprotrain, we have investigated its reactivity to produce through photochemistry a potent nanomolar inhibitor of the kinase DYR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3fd3248a79d43ef381e4337bccb7c6c
https://hal.univ-brest.fr/hal-01517780