OTTERS:a powerful TWAS framework leveraging summary-level reference data

Autor: Dai, Qile, Zhou, Geyu, Zhao, Hongyu, Võsa, Urmo, Franke, Lude, Battle, Alexis, Teumer, Alexander, Lehtimäki, Terho, Raitakari, Olli T., Esko, Tõnu, Agbessi, Mawussé, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand Kumar, Arindrarto, Wibowo, Awadalla, Philip, Beutner, Frank, Jan Bonder, Marc, Boomsma, Dorret I., Christiansen, Mark W., Claringbould, Annique, Deelen, Patrick, Favé, Marie-Julie, Frayling, Timothy, Gharib, Sina A., Gibson, Greg, Heijmans, Bastiaan T., Hemani, Gibran, Jansen, Rick, Kähönen, Mika, Kalnapenkis, Anette, Kasela, Silva, Kettunen, Johannes, Kim, Yungil, Kirsten, Holger, Kovacs, Peter, Krohn, Knut, Kronberg, Jaanika, Kukushkina, Viktorija, Kutalik, Zoltan, Lee, Bernett, Loeffler, Markus, Marigorta, Urko M., Mei, Hailang, Milani, Lili, Montgomery, Grant W., Müller-Nurasyid, Martina, Nauck, Matthias, Nivard, Michel G., Penninx, Brenda, Perola, Markus, Pervjakova, Natalia, Pierce, Brandon L., Powell, Joseph, Prokisch, Holger, Psaty, Bruce M., Ripatti, Samuli, Rotzschke, Olaf, Rüeger, Sina, Saha, Ashis, Scholz, Markus, Schramm, Katharina, Seppälä, Ilkka, Slagboom, Eline P., Stehouwer, Coen D. A., Stumvoll, Michael, Sullivan, Patrick, ‘t Hoen, Peter A. C., Thiery, Joachim, Tong, Lin, Tönjes, Anke, van Dongen, Jenny, van Iterson, Maarten, van Meurs, Joyce, Veldink, Jan H., Verlouw, Joost, Visscher, Peter M., Völker, Uwe, Westra, Harm-Jan, Wijmenga, Cisca, Yaghootkar, Hanieh, Yang, Jian, Zeng, Biao, Zhang, Futao, Epstein, Michael P., Yang, Jingjing

Publikováno v: eQTLGen Consortium 2023, ' OTTERS : a powerful TWAS framework leveraging summary-level reference data ', Nature Communications, vol. 14, no. 1, 1271 . https://doi.org/10.1038/s41467-023-36862-w
Nature Communications, 14(1):1271. Nature Publishing Group UK
Nature Communications, 14(1):1271. Nature Publishing Group
Dai, Q, Zhou, G, Zhao, H, Esko, T, Boomsma, D I, Nivard, M G, van Dongen, J, Epstein, M P, Yang, J & eQTLGen Consortium 2023, ' OTTERS : a powerful TWAS framework leveraging summary-level reference data ', Nature Communications, vol. 14, no. 1, 1271 . https://doi.org/10.1038/s41467-023-36862-w

Most existing TWAS tools require individual-level eQTL reference data and thus are not applicable to summary-level reference eQTL datasets. The development of TWAS methods that can harness summary-level reference data is valuable to enable TWAS in br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8dab0fd328cc49401a235e20c029df7
https://research.vumc.nl/en/publications/c3d690a5-0e48-4778-bab7-0e612d8b2086

Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases

Autor: Kiiskinen, Tuomo, Helkkula, Pyry, Krebs, Kristi, Karjalainen, Juha, Saarentaus, Elmo, Mars, Nina, Lehisto, Arto, Zhou, Wei, Cordioli, Mattia, Jukarainen, Sakari, Rämö, Joel T., Mehtonen, Juha, Veerapen, Kumar, Räsänen, Markus, Ruotsalainen, Sanni, Maasha, Mutaamba, Niiranen, Teemu, Tuomi, Tiinamaija, Salomaa, Veikko, Kurki, Mitja, Pirinen, Matti, Palotie, Aarno, Daly, Mark, Ganna, Andrea, Havulinna, Aki S., Milani, Lili, Ripatti, Samuli

Publikováno v: Nature Medicine. 29:209-218

Little is known about the genetic determinants of medication use in preventing cardiometabolic diseases. Using the Finnish nationwide drug purchase registry with follow-up since 1995, we performed genome-wide association analyses of longitudinal patt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf58c6aa9c292b7fba40d603627b6d1
https://doi.org/10.1038/s41591-022-02122-5

Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development

Autor: Samu N, Kurki, Pavel, Uvarov, Alexey S, Pospelov, Kalevi, Trontti, Antje K, Hübner, Rakenduvadhana, Srinivasan, Masahiko, Watanabe, Iiris, Hovatta, Christian A, Hübner, Kai, Kaila, Mari A, Virtanen

Publikováno v: Cerebral Cortex. 33:5906-5923

The Na-K-2Cl cotransporter NKCC1 is widely expressed in cells within and outside the brain. However, our understanding of its roles in brain functions throughout development, as well as in neuropsychiatric and neurological disorders, has been severel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1675d7539bde8f0051e5a421a767a3
https://doi.org/10.1093/cercor/bhac470

Azulene as a biphenyl mimetic in orexin/hypocretin receptor agonists

Autor: Teppo O. Leino, Ainoleena Turku, Lauri Urvas, Karuna Adhikari, Jouni Oksanen, Yana Steynen, Jari Yli-Kauhaluoma, Henri Xhaard, Jyrki P. Kukkonen, Erik A.A. Wallén

Azulene is a rare ring structure in drugs, and we investigated whether it could be used as a biphenyl mimetic in known orexin receptor agonist Nag 26, which is binding to both orexin receptors OX1 and OX2 with preference towards OX2. The most potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7df09711b7611d8344b9ac76de0bc4c
http://hdl.handle.net/10138/359559

TargIDe : a machine -learning workflow for target identification of molecules with antibiofilm activity against Pseudomonas aeruginosa

Autor: João Carneiro, Rita P. Magalhães, Victor M. de la Oliva Roque, Manuel Simões, Diogo Pratas, Sérgio F. Sousa

Bacterial biofilms are a source of infectious human diseases and are heavily linked to antibiotic resistance. Pseudomonas aeruginosa is a multidrug-resistant bacterium widely present and implicated in several hospital-acquired infections. Over the la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6623907079b7abed4c8acf4469f1eb
http://hdl.handle.net/10138/358420