Výsledky vyhledávání - "1115 Pharmacology and Pharmaceutical Sciences"

Enhancing the Therapeutic Potential of Nanomedicines by Modifying Surface Characteristics

Autor: Gulati, N, Dua, K, Dureja, H

Publikováno v: Current Drug Delivery. 20:1031-1036

Abstract: Nanomedicines have been used over time because of their significant impact on human health care for the prevention, early detection, diagnosis, treatment, and follow-up of a wide range of illnesses. Nanomedicines must be adequately characte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91117037855441d01da062055162652f
https://doi.org/10.2174/1567201819666220508175434

Zobrazit plný text záznamu

Management of Bacterial and Fungal Infections in the ICU: Diagnosis, Treatment, and Prevention Recommendations

Autor: Rawson, TM, Antcliffe, D, Wilson, R, Abdolrasouli, A, Moore, L

Publikováno v: Infection and Drug Resistance. 16:2709-2726

Bacterial and fungal infections are common issues for patients in the intensive care unit (ICU). Large, multinational point prevalence surveys have identified that up to 50% of ICU patients have a diagnosis of bacterial or fungal infection at any one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28daecd833b72a2630f5c37d9b4d0db
https://doi.org/10.2147/idr.s390946

Zobrazit plný text záznamu

Impact of Smoking Status and Nicotine Dependence on Academic Performance of Health Sciences Students

Autor: Jaber S Alqahtani, Abdulelah M Aldhahir, Zaid Alanazi, Emad Zahi Alsulami, Mujahid A Alsulaimani, Abdullah A Alqarni, Abdullah S Alqahtani, Ayadh Yahya AlAyadi, Musallam Alnasser, Ibrahim A AlDraiwiesh, Saeed M Alghamdi, Hussam M Almarkhan, Abdullah S Alsulayyim, Saad M AlRabeeah, Mohammed D AlAhmari

Publikováno v: Substance Abuse and Rehabilitation. 14:13-24

Jaber S Alqahtani,1 Abdulelah M Aldhahir,2 Zaid Alanazi,3 Emad Zahi Alsulami,4 Mujahid A Alsulaimani,5 Abdullah A Alqarni,6 Abdullah S Alqahtani,1 Ayadh Yahya AlAyadi,1 Musallam Alnasser,1 Ibrahim A AlDraiwiesh,1 Saeed M Alghamdi,7 Hussam M Almarkhan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d8ead833c4f06be23dcd786fa0c6c5
https://doi.org/10.2147/sar.s393062

Zobrazit plný text záznamu

Managing Apoptosis in Lung Diseases using Nano-assisted Drug Delivery System

Autor: Kamal Dua, Deepak Kumar, Monu K. Shukla, Amit Dubey, Sadanand Pandey, Sachin K. Singh, Gaurav Gupta, Parteek Prasher, Dinesh K. Chellappan, Brian G. Oliver

Publikováno v: Current Pharmaceutical Design. 28:3202-3211

Abstract: Several factors exist that limit the efficacy of lung cancer treatment. These may be tumor-specific delivery of therapeutics, airway geometry, humidity, clearance mechanisms, presence of lung diseases, and therapy against tumor cell resista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04198418afc8221b945e7a9c2bb4bea0
https://doi.org/10.2174/1381612828666220413103831

Zobrazit plný text záznamu

Identification of Inhibitors of the Schistosoma mansoni VKR2 Kinase Domain

Autor: Indran Mathavan, Lawrence J. Liu, Sean W. Robinson, Nelly El-Sakkary, Adam Jo J. Elatico, Darwin Gomez, Ricky Nellas, Raymond J. Owens, William Zuercher, Iva Navratilova, Conor R. Caffrey, Konstantinos Beis

Publikováno v: ACS Medicinal Chemistry Letters. 13:1715-1722

Schistosomiasis is a neglected tropical disease caused by parasitic flatworms. Current treatment relies on just one partially effective drug, praziquantel (PZQ). Schistosoma mansoni Venus Kinase Receptors 1 and 2 (SmVKR1 and SmVKR2) are important for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd467f9ab145aedfa061c18c71d111d
https://doi.org/10.1021/acsmedchemlett.2c00248

Zobrazit plný text záznamu

Nanoparticulate drugs and vaccines: Breakthroughs and bottlenecks of repurposing in breast cancer

Autor: Kumbhar, P, Kole, K, Khadake, V, Marale, P, Manjappa, A, Nadaf, S, Jadhav, R, Patil, A, Singh, SK, Dua, K, Jha, NK, Disouza, J, Patravale, V

Publikováno v: Journal of Controlled Release. 349:812-830

Breast cancer (BC) is a highly diagnosed and topmost cause of death in females worldwide. Drug repurposing (DR) has shown great potential against BC by overcoming major shortcomings of approved anticancer therapeutics. However, poor physicochemical p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ec3314cbcc848e33ee8614a3b2cfa4
https://doi.org/10.1016/j.jconrel.2022.07.039

Zobrazit plný text záznamu

Natural products as novel anti-obesity agents: insights into mechanisms of action and potential for therapeutic management

Autor: Shaik Mohamed Sayed, UF, Moshawih, S, Goh, HP, Kifli, N, Gupta, G, Singh, SK, Chellappan, DK, Dua, K, Hermansyah, A, Ser, HL, Ming, LC, Goh, BH

Obesity affects more than 10% of the adult population globally. Despite the introduction of diverse medications aimed at combating fat accumulation and obesity, a significant number of these pharmaceutical interventions are linked to substantial occu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::f16fbd94bc754cf5622a5eac57a8d6ab
https://hdl.handle.net/10453/170829

Zobrazit plný text záznamu

Berberine nanostructures attenuate ß-catenin, a key component of epithelial mesenchymal transition in lung adenocarcinoma

Autor: Malyla, V, De Rubis, G, Paudel, KR, Chellappan, DK, Hansbro, NG, Hansbro, PM, Dua, K

Lung cancer (LC) is the leading cause of cancer-related deaths globally. It accounts for more than 1.9 million cases each year due to its complex and poorly understood molecular mechanisms that result in unregulated cell proliferation and metastasis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::c43765902161ca34fbd078e976f082e4
https://hdl.handle.net/10453/170599

Zobrazit plný text záznamu

Understanding the Stabilizing Effect of Histidine on mAb Aggregation: A Molecular Dynamics Study

Autor: Suman Saurabh, Cavan Kalonia, Zongyi Li, Peter Hollowell, Thomas Waigh, Peixun Li, John Webster, John M. Seddon, Jian R. Lu, Fernando Bresme

Publikováno v: Molecular Pharmaceutics. 19:3288-3303

Histidine, a widely used buffer in monoclonal antibody (mAb) formulations, is known to reduce antibody aggregation. While experimental studies suggest a nonelectrostatic, nonstructural (relating to secondary structure preservation) origin of the phen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cfc736a2bbb02338069722ffd49724
https://doi.org/10.1021/acs.molpharmaceut.2c00453

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání