Zobrazeno 1 - 10
of 19
pro vyhledávání: '"111207 Molecular Targets"'
Autor:
Daniel Ryan (7898252)
Molecular testing for targetable driver mutations is fundamental in advanced stage lung cancer. Small diagnostic tissue samples can miss driver mutations and fail to reflect intratumour heterogeneity (ITGH). Liquid biopsies are non-invasive and may b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d88209b7bb9db204fd2189d84d81a08
Autor:
Emagha, Unwana
Bloodstream infections carry a high economic and health burdenand can develop into invasive life-threatening conditions such as sepsis, meningitis and infective endocarditis, characterised byaberrant thrombus formation and endothelial dysregulation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad1c3f81363d3a6a3b10fefd091cc2c
Publikováno v:
Journal of Organometallic Chemistry. 883:86-89
The first examples of adenine binding by isomeric organoplatinum(II) complexes bearing H-bonding nicotinic and isonicotinic acid ligands are reported. Notably, a subtle switching of the H-bonding functionality from the 3- to 4-position of the pyridyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb09fc7535c09b2d49dc0e1c66f8040e
https://doi.org/10.1016/j.jorganchem.2018.12.005
https://doi.org/10.1016/j.jorganchem.2018.12.005
Autor:
Powles, Thomas, Sridhar, Srikala S., Loriot, Yohann, Bellmunt, Joaquim, Jasmine Mu, Xinmeng, A. Ching, Keith, Pu, Jie, Sternberg, Cora N., Petrylak, Daniel P., Tambaro, Rosa, Dourthe, Louis M., ��lvarez-Fern��ndez, Carlos, Aarts, Maureen, Pietro, Alessandra di, Grivas, Petros, Davis, Craig B.
These figures contain details of the study population, elastic net model parameters, and CytoPro method validation.These tables report results from statistical analyses of biomarker associations with overall survival in JAVELIN Bladder 100.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cecb6509dfe7167da2699dc8ddb8525
Autor:
Thamil Vaani Komarasamy
Zika virus infection has been associated with adverse pregnancy and birth outcomes with numerous neurological complications such as microcephaly and other congenital abnormalities. When a virus infects a host cell, it alters host cell protein product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b50be9ea001327a96a4d62c17d14475
Autor:
Pal, Arpita S
Lung cancer is the third most prevalent cancer in the world; however it is the leading cause of cancer related deaths worldwide. Non-small cell lung cancer (NSCLC) accounts for ~85% of the lung cancer cases. The current strategies to treat NSCLC pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219c87038e48861d505143cd9b657a0b
Autor:
Neha S. Gandhi, Deirdre R. Coombe
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 9 (2019)
Frontiers in Oncology, Vol 9 (2019)
Heparanase has been viewed as a promising anti-cancer drug target for almost two decades, but no anti-heparanase therapy has yet reached the clinic. This endoglycosidase is highly expressed in a variety of malignancies, and its high expression is ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfaf64441087ed853a91b9094f72734
https://doi.org/10.3389/fonc.2019.01316
https://doi.org/10.3389/fonc.2019.01316
Pre-mRNA splicing is an important biological process that allows production of multiple proteins from a single gene in the genome, and mainly contributes to protein diversity in eukaryotic organisms. Alternative splicing is commonly governed by RNA b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262cb3d8960605921f668098bf181eb6
Autor:
JAY JOHN HOCKING
Multiple myeloma is an incurable haematologic malignancy. This thesis examines the use of a new medication that targets a specific mutation present in multiple myeloma. We show this treatment is effective in a subset of myeloma, and its effects enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a49cd48589097ece42e6d3ace02fc662
Major facilitator superfamily domain-containing protein-2a (Mfsd2a) which was considered as an orphan transporter has recently gained attention for its regulatory role in the maintenance of proper functioning of the blood-brain barrier. Besides the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6658e110be3805838a09d08a974ee5ba