Zobrazeno 1 - 10 of 44 pro vyhledávání: '"101/28"'
2
Activation mechanism of the class D fungal GPCR dimer Ste2
Autor: Vaithish Velazhahan, Ning Ma, Nagarajan Vaidehi, Christopher G. Tate
Publikováno v: Nature. 603:743-748
The fungal class D1 G-protein-coupled receptor (GPCR) Ste2 has a different arrangement of transmembrane helices compared with mammalian GPCRs and a distinct mode of coupling to the heterotrimeric G protein Gpa1–Ste2–Ste181. In addition, Ste2 lack
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a00b52c83b6da6a0f3f5846c3d80fe
https://doi.org/10.1038/s41586-022-04498-3
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4
α-Synuclein fibril and synaptic vesicle interactions lead to vesicle destruction and increased lipid-associated fibril uptake into iPSC-derived neurons
Autor: Stephens, Amberley D, Villegas, Ana Fernandez, Chung, Chyi Wei, Vanderpoorten, Oliver, Pinotsi, Dorothea, Mela, Ioanna, Ward, Edward, McCoy, Thomas M, Cubitt, Robert, Routh, Alexander F, Kaminski, Clemens F, Kaminski Schierle, Gabriele S
Publikováno v: Communications Biology, 6
Monomeric alpha-synuclein (aSyn) is a well characterised protein that importantly binds to lipids. aSyn monomers assemble into amyloid fibrils which are localised to lipids and organelles in insoluble structures found in Parkinson's disease patient's
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baa7f119b85759d35dccc34ca72fcad
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5
MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA
Autor: Qin Yu, Yorgo Modis, Alba Herrero del Valle, Rahul Singh
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, 12 (1)
Nature Communications
Our innate immune responses to viral RNA are vital defenses. Long cytosolic double-stranded RNA (dsRNA) is recognized by MDA5. The ATPase activity of MDA5 contributes to its dsRNA binding selectivity. Mutations that reduce RNA selectivity can cause a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be0473d4f75a5612346c5478f88ed7f
https://doaj.org/article/4ed51115fdf7407f8d5ba6033a51c511
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6
Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution
Autor: Nejc Kejzar, Elina Laanto, Ilona Rissanen, Vahid Abrishami, Muniyandi Selvaraj, Sylvain Moineau, Janne Ravantti, Lotta-Riina Sundberg, Juha T. Huiskonen
The origin of viruses remains an open question. While lack of detectable sequence similarity hampers the analysis of distantly related viruses, structural biology investigations of conserved capsid protein structures facilitate the study of distant e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b7e34a0bc0a832805b8698253da5b5
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7
Donor-strand exchange drives assembly of the TasA scaffold in Bacillus subtilis biofilms
Autor: Jan Böhning, Mnar Ghrayeb, Conrado Pedebos, Daniel K. Abbas, Syma Khalid, Liraz Chai, Tanmay A. M. Bharat
Many bacteria in nature exist in multicellular communities termed biofilms, where cells are embedded in an extracellular matrix that provides rigidity to the biofilm and protects cells from chemical and mechanical stresses. In the Gram-positive model
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae94cd0ad40ef069d0eb60f8ed9c9381
https://www.repository.cam.ac.uk/handle/1810/344554
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8
Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti
Autor: Yoann Saucereau, Tom H. Wilson, Matthew C. K. Tang, Martin C. Moncrieffe, Steven W. Hardwick, Dimitri Y. Chirgadze, Sandro G. Soares, Maria Jose Marcaida, Nick Gay, Monique Gangloff
Aedes aegypti can act as a vector for viral pathogens but the mechanism of viral resistance and evolving host-pathogen tolerance are poorly understood. Here the authors structurally characterise a duplicated pair of interacting Toll immunoreceptors a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65d6b47144d1c470df66fe7b6c819cb
https://www.repository.cam.ac.uk/handle/1810/341567
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9
AAV9-mediated Schwann cell-targeted gene therapy rescues a model of demyelinating neuropathy
Autor: Kleopas A. Kleopa, Christina Tryfonos, Alexia Kagiava, Irene Sargiannidou, Amanda Heslegrave, Christos Karaiskos, Henrik Zetterberg, Rita Horvath, Matthew J. Jennings, Marina Stavrou, Mary M. Reilly, Jan Richter, Christina Christodoulou
Publikováno v: Gene Therapy
Funder: The Republic of Cyprus through the Research and Innovation Foundation Foundation (Project: CULTURE/BR-NE/0416/07)
Funder: Wallenberg Scholar and the fluid biomarker measurements in the lab of HZ and AJH were supported by the UK Dementia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a7d016c910d27a9d4d31b885ccc7eb
https://doi.org/10.1038/s41434-021-00250-0
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10
The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis
Autor: L. F. L. Wilson, T. Dendooven, S. W. Hardwick, A. Echevarría-Poza, T. Tryfona, K. B. R. M. Krogh, D. Y. Chirgadze, B. F. Luisi, D. T. Logan, K. Mani, P. Dupree
Funder: University of Cambridge; doi: https://doi.org/10.13039/501100000735
Funder: AstraZeneca; doi: https://doi.org/10.13039/100004325
Funder: RCUK | Biotechnology and Biological Sciences Research Council (BBSRC); doi: https://doi.org/10.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411486da94d4cb16bd50cc82cd3b0560
https://www.repository.cam.ac.uk/handle/1810/338975
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Plný text Recenzováno Digitální knihovna AV ČR
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