Zobrazeno 1 - 10
of 723
pro vyhledávání: '"10061 Institute of Molecular Cancer Research"'
Autor:
Müller, Anne, He, Jiazhuo
Publikováno v:
New England Journal of Medicine. 388:1225-1229
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388a855713b7420975627fe44baf6bca
https://doi.org/10.1056/nejme2215503
https://doi.org/10.1056/nejme2215503
Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids
Autor:
Stoy, Henriette, Zwicky, Katharina, Kuster, Danina, Lang, Kevin S, Krietsch, Jana, Crossley, Magdalena P, Schmid, Jonas A, Cimprich, Karlene A, Merrikh, Houra, Lopes, Massimo
Publikováno v:
Nature Structural & Molecular Biology. 30:348-359
Transcription-replication collisions (TRCs) are crucial determinants of genome instability. R-loops were linked to head-on TRCs and proposed to obstruct replication fork progression. The underlying mechanisms, however, remained elusive due to the lac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eaac980854d67ab3e7fbe7a03197866
https://doi.org/10.1038/s41594-023-00928-6
https://doi.org/10.1038/s41594-023-00928-6
Autor:
Martinikova, Andra S, Stoyanov, Miroslav, Oravetzova, Anna, Kok, Yannick P, Yu, Shibo, Dobrovolna, Jana, Janscak, Pavel, van Vugt, Marcel, Macurek, Libor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d31ee099733d2f9be003a1b8e191c3
https://www.zora.uzh.ch/id/eprint/234309/
https://www.zora.uzh.ch/id/eprint/234309/
Autor:
Andrs, Martin, Stoy, Henriette, Boleslavska, Barbora, Chappidi, Nagaraja, Kanagaraj, Radhakrishnan, Nascakova, Zuzana, Menon, Shruti, Rao, Satyajeet, Oravetzova, Anna, Dobrovolna, Jana, Surendranath, Kalpana, Lopes, Massimo, Janscak, Pavel
Elevated levels of reactive oxygen species (ROS) reduce replication fork velocity by causing dissociation of the TIMELESS-TIPIN complex from the replisome. Here, we show that ROS generated by exposure of human cells to the ribonucleotide reductase in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6c8fd3d1b400ea1609067e8cc5c07c
https://www.zora.uzh.ch/id/eprint/234308/
https://www.zora.uzh.ch/id/eprint/234308/
Autor:
Han, Zhe, Andrs, Martin, Madhavan, Bindhu K, Kaymak, Serap, Sulaj, Alba, Kender, Zoltan, Kopf, Stefan, Kihm, Lars, Pepperkok, Rainer, Janscak, Pavel, Nawroth, Peter, Kumar, Varun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e826baaffc2647b591ef8d3a6bbcb3
Autor:
Reuter, Sebastian, Raspe, Jonas, Uebner, Hendrik, Contoyannis, Alexandros, Pastille, Eva, Westendorf, Astrid M, Caso, Georgia C, Cover, Timothy L, Müller, Anne, Taube, Christian
BackgroundAsthma is an incurable heterogeneous disease with variations in clinical and underlying immunological phenotype. New approaches could help to support existing therapy concepts. Neonatal infection of mice with Helicobacter pylori or administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50fac2696cd4a270c00868f42fd11ea
https://www.ncbi.nlm.nih.gov/pubmed/36761723
https://www.ncbi.nlm.nih.gov/pubmed/36761723
Autor:
Boonen, Rick A C M, Wiegant, Wouter W, Celosse, Nandi, Vroling, Bas, Heijl, Stephan, Kote-Jarai, Zsofia, Mijuskovic, Martina, Cristea, Simona, Solleveld-Westerink, Nienke, van Wezel, Tom, Beerenwinkel, Niko, Eeles, Rosalind, Devilee, Peter, Vreeswijk, Maaike P G, Marra, Giancarlo, van Attikum, Haico
Publikováno v:
Cancer Research, 82 (4)
Cancer Research, 82(4), 615-631. AMER ASSOC CANCER RESEARCH
Cancer Research, 82(4), 615-631. AMER ASSOC CANCER RESEARCH
Heterozygous carriers of germline loss-of-function variants in the tumor suppressor gene checkpoint kinase 2 (CHEK2) are at an increased risk for developing breast and other cancers. While truncating variants in CHEK2 are known to be pathogenic, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5366d9302b7f65035ddfaa5aff5f71e
https://doi.org/10.1158/0008-5472.can-21-1845
https://doi.org/10.1158/0008-5472.can-21-1845
Autor:
Boleslavska, Barbora, Oravetzova, Anna, Shukla, Kaustubh, Nascakova, Zuzana, Ibini, Oluwakemi Ngozi, Hasanova, Zdenka, Andrs, Martin, Kanagaraj, Radhakrishnan, Dobrovolna, Jana, Janscak, Pavel
Publikováno v:
Nucleic acids research.
R-loops are three-stranded nucleic acid structures composed of an RNA:DNA hybrid and displaced DNA strand. These structures can halt DNA replication when formed co-transcriptionally in the opposite orientation to replication fork progression. A recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d06c3b1d1ba6ab9b8d0518ced25b247
https://pubmed.ncbi.nlm.nih.gov/36453994
https://pubmed.ncbi.nlm.nih.gov/36453994
Autor:
Kurt Jacobs, Cyril Doerdelmann, Jana Krietsch, Daniel González-Acosta, Nicolas Mathis, Saul Kushinsky, Estrella Guarino, Carmen Gómez-Escolar, Dolores Martinez, Jonas A. Schmid, Peter J. Leary, Raimundo Freire, Almudena R. Ramiro, Christine M. Eischen, Juan Mendez, Massimo Lopes
Publikováno v:
Mol Cell
Stem cell division is linked to tumorigenesis by yet-elusive mechanisms. The hematopoietic system reacts to stress by triggering hematopoietic stem and progenitor cell (HSPC) proliferation, which can be accompanied by chromosomal breakage in activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7beccda09e45b21eae3c4f4c087add
https://hdl.handle.net/20.500.12105/15286
https://hdl.handle.net/20.500.12105/15286
Autor:
Dibitetto, Diego, Marshall, Shannon, Sanchi, Andrea, Liptay, Martin, Badar, Jumana, Lopes, Massimo, Rottenberg, Sven, Smolka, Marcus B.
The DNA-PKcs kinase mediates the repair of DNA double-strand breaks via classical non-homologous end joining (NHEJ). DNA-PKcs is also recruited to active replication forks, although a role for DNA-PKcs in the control of fork dynamics is unclear. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79c7b72b27d0dae510374e8956777f4
https://doi.org/10.5167/uzh-231951
https://doi.org/10.5167/uzh-231951