Zobrazeno 1 - 10
of 1 100
pro vyhledávání: '"10019 Department of Biochemistry"'
Publikováno v:
Annual Review of Biophysics. 52:433-462
Many proteins contain large structurally disordered regions or are entirely disordered under physiological conditions. The functions of these intrinsically disordered proteins (IDPs) often involve interactions with other biomolecules. An important em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a151792e5911ce003c51ca87fbe90a9f
https://doi.org/10.1146/annurev-biophys-101122-071930
https://doi.org/10.1146/annurev-biophys-101122-071930
Autor:
Kiss, Cedric, Gall, Flavio M, Dreier, Birgit, Adams, Michael, Riedl, Rainer, Plückthun, Andreas, Mittl, Peer R E
Publikováno v:
Acta Crystallographica Section D Structural Biology. 78:1439-1450
Peptides comprising many hydrophobic amino acids are almost insoluble under physiological buffer conditions, which complicates their structural analysis. To investigate the three-dimensional structure of the hydrophobic leucinostatin derivative ZHAWO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b410e6e24f173fe03eacaea7dbb384c
https://doi.org/10.1107/s2059798322010762
https://doi.org/10.1107/s2059798322010762
Autor:
Freitag, Patrick C, Kaulfuss, Meike, Flühler, Lea, Mietz, Juliane, Weiss, Fabian, Brücher, Dominik, Kolibius, Jonas, Hartmann, K Patricia, Smith, Sheena N, Münz, Christian, Chijioke, Obinna, Plückthun, Andreas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b269596a03c5e27f017816c4dff125
https://www.zora.uzh.ch/id/eprint/233903/
https://www.zora.uzh.ch/id/eprint/233903/
Autor:
Andrea Dalle Vedove, Giulia Cazzanelli, Laurent Batiste, Jean-Rémy Marchand, Dimitrios Spiliotopoulos, Jessica Corsi, Vito Giuseppe D’Agostino, Amedeo Caflisch, Graziano Lolli
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1434-1443
BAZ2A is an epigenetic regulator affecting transcription of ribosomal RNA. It is overexpressed in aggressive and recurrent prostate cancer, promoting cellular migration. Its bromodomain is characterized by a shallow and difficult-to-drug pocket. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b542646d355aeeef41490b1c3531e2c
https://doi.org/10.1021/acsmedchemlett.2c00173
https://doi.org/10.1021/acsmedchemlett.2c00173
Autor:
Strubel, Alexander, Münick, Philipp, Chaikuad, Apirat, Dreier, Birgit, Schaefer, Jonas, Gebel, Jakob, Osterburg, Christian, Tuppi, Marcel, Schäfer, Birgit, Knapp, Stefan, Plückthun, Andreas, Dötsch, Volker
Publikováno v:
Cell Death & Differentiation. 29:2445-2458
The function of the p53 transcription factor family is dependent on several folded domains. In addition to a DNA-binding domain, members of this family contain an oligomerization domain. p63 and p73 also contain a C-terminal Sterile α-motif domain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3999307ca1fa599d9df6d19a933a71a
https://doi.org/10.1038/s41418-022-01030-y
https://doi.org/10.1038/s41418-022-01030-y
Autor:
Ramanadane, Karthik, Liziczai, Márton, Markovic, Dragana, Straub, Monique S, Rosalen, Gian T, Udovcic, Anto, Dutzler, Raimund, Manatschal, Cristina
Publikováno v:
eLife. 12
The transport of transition metal ions by members of the SLC11/NRAMP family constitutes a ubiquitous mechanism for the uptake of Fe2+ and Mn2+ across all kingdoms of life. Despite the strong conservation of the family, two of its branches have evolve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7fb5a0f80bdc139f27ebb040a6d562
https://doi.org/10.7554/elife.85641
https://doi.org/10.7554/elife.85641
Autor:
Schubert, Rajib, Bae, Taegeun, Simic, Branko, Smith, Sheena N, Park, Seong-Ho, Nagy-Davidescu, Gabriela, Gradinaru, Viviana, Plückthun, Andreas, Hur, Junho K
Tissue clearing combined with deep imaging has emerged as a powerful technology to expand classical histological techniques. Current techniques have been optimized for imaging sparsely pigmented organs such as the mammalian brain. In contrast, melani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941ba716b84614aa2bf9a446f27d12f3
https://resolver.caltech.edu/CaltechAUTHORS:20230525-772152300.6
https://resolver.caltech.edu/CaltechAUTHORS:20230525-772152300.6
Autor:
Adam Karoutas, Witold Szymanski, Tobias Rausch, Sukanya Guhathakurta, Eva A. Rog-Zielinska, Remi Peyronnet, Janine Seyfferth, Hui-Ru Chen, Rebecca de Leeuw, Benjamin Herquel, Hiroshi Kimura, Gerhard Mittler, Peter Kohl, Ohad Medalia, Jan O. Korbel, Asifa Akhtar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f40791bb094a69705e68e299b588cb
https://doi.org/10.5167/uzh-232288
https://doi.org/10.5167/uzh-232288
Autor:
Christoph Klenk, Maria Scrivens, Anina Niederer, Shuying Shi, Loretta Mueller, Elaine Gersz, Maurice Zauderer, Ernest S. Smith, Ralf Strohner, Andreas Plückthun
Directed evolution in bacterial or yeast display systems has been successfully used to improve stability and expression of G protein-coupled receptors for structural and biophysical studies. Yet, several receptors cannot be tackled in microbial syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2453d77035b033dc3434d9e096e17f47
https://www.zora.uzh.ch/id/eprint/233902/
https://www.zora.uzh.ch/id/eprint/233902/
Autor:
Lehmann, Elena Farah, Liziczai, Márton, Drożdżyk, Katarzyna, Altermatt, Patrick, Langini, Cassiano, Manolova, Vania, Sundstrom, Hanna, Dürrenberger, Franz, Dutzler, Raimund, Manatschal, Cristina
Publikováno v:
eLife. 12
A central regulatory mechanism of iron homeostasis in humans involves ferroportin (FPN), the sole cellular iron exporter, and the peptide hormone hepcidin, which inhibits Fe2+ transport and induces internalization and degradation of FPN. Dysregulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c0429acddac41b3b045f9f6113f656
https://doi.org/10.7554/elife.83053
https://doi.org/10.7554/elife.83053