Studying the adaptogenic activity of a series of tetrahydropyrido[2,1-b] [1,3,5] thiadiazine derivatives

Autor: E. Yu. Bibik, I. A. Nekrasa, A. V. Demenko, K. A. Frolov, V. V. Dotsenko, S. G. Krivokolysko

Publikováno v: Бюллетень сибирской медицины, Vol 18, Iss 3, Pp 21-28 (2019)

Introduction. In the modern world people are exposed to the influence of adverse psychological and physical factors, escalating in intensity. The search for new pharmacodynamic effects of [1,3,5]-thiadiazine derivatives designated by significant biol

Externí odkaz: https://doaj.org/article/2e60ea1c02894f95b21db4df182fa1bb

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DESIGN OF SF3B1 SUBUNIT MODULATORS OF THE SF3B SPLICEOSOME COMPLEX

Autor: Randazzo, Ornella

Publikováno v: Randazzo, O 2022, ' Design of SF3B1 subunit modulators of the SF3B spliceosome complex ', PhD, Vrije Universiteit Amsterdam .
Randazzo, O 2022, ' Design of SF3B1 subunit modulators of the SF3B spliceosome complex ', Doctor of Philosophy, Vrije Universiteit Amsterdam . < https://hdl.handle.net/1871.1/053bd79d-15bd-42aa-bd0f-bfab5f5d94f4 >

The subject of this dissertation is the search for new therapeutic strategies for pancreatic cancer and aims to implement a Drug Discovery process for the rational design and synthesis of molecules active in the modulation of pathways related to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a1db90dcf5a5a71c518fef3703ad6daa
http://hdl.handle.net/10447/533610

Crystal structure and identification of a pyrimido[6,1-b][1,3]oxazin-6-one derivative from the reaction of acrolein with 5-(phenoxymethyl)-2-amino-2-oxazoline

Autor: Pascal Sonnet, Jean Guillon, Solène Savrimoutou, Sandra Rubio, Stéphane Moreau, Mathieu Marchivie, François Hallé

Publikováno v: Comptes Rendus. Chimie
Comptes Rendus. Chimie, Académie des sciences (Paris), 2018, 21 (11), pp.987-992. ⟨10.1016/j.crci.2018.09.013⟩
Comptes Rendus. Chimie, 2018, 21 (11), pp.987-992. ⟨10.1016/j.crci.2018.09.013⟩

International audience; The X-ray crystal structure of 2-(4,5-dihydro-5-phenoxymethyl-1,3-oxazol-2-ylamino)-7-(2-hydroxy-3-phenoxypropyl)hexahydro-2H,6H-pyrimido[6,1-b][1,3]oxazin-6-one (1), a structure of adduct formed by the reaction of 5-(phenoxym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8c633a0bf0a982f157c62f2378c9e6
https://doi.org/10.1016/j.crci.2018.09.013

Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives against Pancreatic Cancer Cells*

Autor: Giovanna Li Petri, Patrizia Diana, Elisa Giovannetti, Godefridus J. Peters, Stella Cascioferro, Barbara Parrino, Btissame El Hassouni, Girolamo Cirrincione, Daniela Carbone

Publikováno v: Anticancer Research, 39(7), 3615-3620. International Institute of Anticancer Research
Li Petri, G, Cascioferro, S, el Hassouni, B, Carbone, D, Parrino, B, Cirrincione, G, Peters, G J, Diana, P & Giovannetti, E 2019, ' Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives against Pancreatic Cancer Cells* ', Anticancer Research, vol. 39, no. 7, pp. 3615-3620 . https://doi.org/10.21873/anticanres.13509

Heterocyclic rings are recognized as key components of many natural, semi-synthetic and synthetic molecules with a broad spectrum of biological activities. Among these molecules, the indole and imidazo[2,1-b][1,3,4]thiadiazole systems have recently b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::befd9a0f4921b003bef1c177b66e796e
https://research.vumc.nl/en/publications/7406b72f-5dc6-44f3-8d98-9d5cf83e1d41