Metabolic engineering of Bacillus amyloliquefaciens for efficient production of α-glucosidase inhibitor1-deoxynojirimycin

Autor: Xujie Li, Meng Zhang, Yu Lu, Ningyang Wu, Jian'gang Chen, Zhixia Ji, Yangyang Zhan, Xin Ma, Junyong Chen, Dongbo Cai, Shouwen Chen

Publikováno v: Synthetic and Systems Biotechnology, Vol 8, Iss 3, Pp 378-385 (2023)

Owing to the feature of strong α-glucosidase inhibitory activity, 1-deoxynojirimycin (1-DNJ) has broad application prospects in areas of functional food, biomedicine, etc., and this research wants to construct an efficient strain for 1-DNJ productio

Externí odkaz: https://doaj.org/article/0372c22f802848ee99fd537b5ed2bfd9

Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors

Autor: Ana I. Ahuja-Casarín, Penélope Merino-Montiel, José Luis Vega-Baez, Sara Montiel-Smith, Miguel X. Fernandes, Irene Lagunes, Inés Maya, José M. Padrón, Óscar López, José G. Fernández-Bolaños

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 138-146 (2021)

We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. Compounds are comprised of three key structural motifs: the iminosugar, for interaction with cholinesterase catalytic anionic

Externí odkaz: https://doaj.org/article/c92efde9bb9247df94bfcbcfbdc69f9c

Determination of 1-Deoxynojirimycin (1-DNJ) in Leaves of Italian or Italy-Adapted Cultivars of Mulberry (Morus sp.pl.) by HPLC-MS

Autor: Lucia Marchetti, Alessio Saviane, Antonella dalla Montà, Graziella Paglia, Federica Pellati, Stefania Benvenuti, Davide Bertelli, Silvia Cappellozza

Publikováno v: Plants, Vol 10, Iss 8, p 1553 (2021)

Recently, 1-DNJ has been widely studied by scientists for its capacity to inhibit α-glucosidase and reduce postprandial blood glucose and fat accumulation. To the best of our knowledge, this is the first analytical determination of 1-DNJ in Morus sp

Externí odkaz: https://doaj.org/article/04f4bffc30c34d04830541cfa05e2ed4

Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors

Autor: José M. Padrón, Sara Montiel-Smith, José Luis Vega-Baez, Óscar López, José G. Fernández-Bolaños, Penélope Merino-Montiel, Inés Maya, Ana I Ahuja-Casarín, Miguel X. Fernandes, Irene Lagunes

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 138-146 (2021)
idUS. Depósito de Investigación de la Universidad de Sevilla
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We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. Compounds are comprised of three key structural motifs: the iminosugar, for interaction with cholinesterase catalytic anionic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dbbea38adbde4e30d41c3de35afa569
https://doaj.org/article/c92efde9bb9247df94bfcbcfbdc69f9c

Kinetic analysis of inhibition of α-glucosidase by leaf powder from Morus australis and its component iminosugars

Autor: Ying Qiao, Teisuke Takita, Juri Nakayama, Takeaki Ikeuchi, Kenji Kojima, Toshiyuki Kimura, Kiyoshi Yasukawa, Masaaki Ito

Publikováno v: Bioscience, Biotechnology, and Biochemistry. 84:2149-2156

Mulberry leaves contain iminosugars, such as 1-deoxynojirimycin (1-DNJ), fagomine, and 2-O-α-D-galactopyranosyl deoxynojirimycin (GAL-DNJ) that inhibit α-glucosidase. In this study, we quantified iminosugars in Morus australis leaves and made the k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1c5a7d2e1569b9ca0c9ac3bc75e2a4
https://doi.org/10.1080/09168451.2020.1783991