Zobrazeno 1 - 10
of 232
pro vyhledávání: '"1 3 4 thiadiazole derivatives"'
Publikováno v:
Research Journal of Pharmacy and Technology. :5293-5296
1,3,4-Thiadiazole is an important heterocyclic moiety, forms an integral core structural component of different categories of drugs such as antimicrobial, antitubercular, anti-inflammatory, antiepileptic, antiviral, antineoplastics, and analgesic age
Publikováno v:
East European Scientific Journal. 1:54-61
The article describes the synthesis of new modifications of derivatives of 6-phenyl-, 6-piodophenyl- and 6-p-bromophenylimidazo[2,1-b][1,3,4]-thiadiazoles - N -((6-(4-iodophenyl)-2-R-imidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methyl)-alkyl/ heterylamine b
Autor:
Khalid Zain Alabdeen
Publikováno v:
Journal of Petroleum Research and Studies. 2:59-88
That Thiadiazoles derivative is biologically active as antimicrobial agents in cooling fluids. Derivatives of 1, 3, 4- thiadiazole have prepared: 2-amino-3-[(2-amino-1, 3, 4-thiadiazol-5-yl) dithio] propanoic acid. 2-(2-Carbethoxyamino-1, 3, 4-thiadi
Publikováno v:
Journal of Agricultural and Food Chemistry. 69:4645-4654
A series of novel 6-sulfonyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives were designed and synthesized. CoMFA models were established to analyze the quantitative structure-activity relationships on the basis of the EC50 values of the compound
Publikováno v:
Polycyclic Aromatic Compounds. 42:4240-4254
An efficient rapid synthesis of a new class of diversely functionalized 6-phenyl-3-(1H-pyrazol-1-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives (4a–q) is described via a facile one-pot, t...
Publikováno v:
ChemistrySelect. 5:12087-12097
Publikováno v:
Letters in Organic Chemistry. 17:517-522
In the current study, a green, one-pot, three-component reaction was performed to prepare novel N-substituted 5-amino-1,3,4-thiadiazole derivatives. The thiadiazoles were obtained from the reaction of a ketene S,S-acetal of Meldrum’s acid or barbit
Autor:
Mantelingu Kempegowda, Hassan A. Swarup, Kemparaje Gowda, Rangappa S. Kanchugarkoppal, Sandhya C. Nagarakere, Shobith Rangappa
Publikováno v:
Synthetic Communications. 50:1528-1544
A series of 2,5-disubstituted 1,3,4-thiadiazole was synthesized and evaluated for their antioxidant and molecular docking studies. These molecules were efficiently synthesized under mild and inexpensive starting material. Construction of these molecu
Autor:
Sudipta Saha, Vinit Raj, Ashok K. Singh, Amit Rai, Amit K Keshari, Mohamed H. Aboumanei, Suraj P. Verma
Publikováno v:
Pharmaceutical Chemistry Journal. 54:12-25
Interleukin-6 (IL-6) is the new molecular target to treat colorectal cancer (CRC) for investigation of potential lead molecules. The main objective of this study was to develop the three-dimensional quantitative structure – activity relationship (3
Publikováno v:
Journal of the Iranian Chemical Society. 17:2083-2094
γ-Secretase inhibitors (GSIs) are repurposed as cancer therapeutics based on the promising inhibition of NOTCH1 signalling pathway in various cancers. GSIs are a class of small-molecule compounds that target the Notch pathway and have been tested to