Zobrazeno 1 - 10
of 59
pro vyhledávání: '"030406 Proteins and Peptides"'
Autor:
Brett Hamilton, Paul F. Alewood, Yanni K.-Y. Chin, Jennifer J. Smith, Ben Cristofori-Armstrong, Eivind A. B. Undheim, Jan Tytgat, Zoltan Dekan, Sónia Troeira Henriques, Bruno Madio, Steve Peigneur, Glenn F. King, Berin A. Boughton
Publikováno v:
Cellular and Molecular Life Sciences
Sea anemone venoms have long been recognized as a rich source of peptides with interesting pharmacological and structural properties, but they still contain many uncharacterized bioactive compounds. Here we report the discovery, three-dimensional str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbfcdb65e809054c6233015877da770f
https://doi.org/10.1007/s00018-018-2897-6
https://doi.org/10.1007/s00018-018-2897-6
Publikováno v:
Oncotarget
The neural-specific transcription factor Engrailed 1 - is overexpressed in basal-like breast tumours. Synthetic interference peptides - comprising a cell-penetrating peptide/nuclear localisation sequence and the Engrailed 1-specific sequence from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92cf07e9b3588ed293a18589ac78968
http://europepmc.org/articles/PMC5976472
http://europepmc.org/articles/PMC5976472
Autor:
Imala Alwis, Jorge Ripoll-Rozada, Pedro Pereira, Choy-Theng Loh, Mike Wu, Robert E. Thompson, Gottfried Otting, Shaun P. Jackson, Emma E. Watson, Xuyu Liu, Richard J. Payne, Benjamin L. Parker, Alessandro Gori
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Central Science, Vol 4, Iss 4, Pp 468-476 (2018)
ACS Central Science
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Central Science, Vol 4, Iss 4, Pp 468-476 (2018)
ACS Central Science
The anophelins are small protein thrombin inhibitors that are produced in the salivary glands of the Anopheles mosquito to fulfill a vital role in blood feeding. A bioinformatic analysis of anophelin sequences revealed the presence of conserved tyros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3458cdb95b6867cf76f215a2669021
https://doi.org/10.1021/acscentsci.7b00612
https://doi.org/10.1021/acscentsci.7b00612
Publikováno v:
Neuropharmacology
Spider peptide toxins have attracted attention because of their ability to target voltage-gated ion channels, which are involved in several pathologies including chronic pain and some cardiovascular conditions. A class of these peptides acts by modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1a966ba144df9580a2185878effda5
https://doi.org/10.1016/j.neuropharm.2017.04.004
https://doi.org/10.1016/j.neuropharm.2017.04.004
Autor:
David J. Craik, Alysha G. Elliott, Yen-Hua Huang, Nicole Lawrence, Mark E. Cooper, Aurélie H. Benfield, Stephanie Chaousis, Olivier Cheneval, Sónia Troeira Henriques, Lai Yue Chan, Angela M. Kavanagh, Anjaneya S. Ravipati
Publikováno v:
ACS Chemical Biology
Gomesin, a disulfide-rich antimicrobial peptide produced by the Brazilian spider Acanthoscurria gomesiana, has been shown to be potent against Gram-negative bacteria and to possess selective anticancer properties against melanoma cells. In a recent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7463082d30e58b13c9b13a56d706128b
https://doi.org/10.1021/acschembio.7b00459
https://doi.org/10.1021/acschembio.7b00459
Autor:
Charles G. Cranfield, Boris Martinac, Paul Duckworth, Bruce Cornell, Sónia Troeira Henriques, David J. Craik
Publikováno v:
Langmuir
© 2017 American Chemical Society. Cyclotides are cyclic disulfide-rich peptides that are chemically and thermally stable and possess pharmaceutical and insecticidal properties. The activities reported for cyclotides correlate with their ability to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea94e4bab1bd05f4672d33e1b3ce218
https://doi.org/10.1021/acs.langmuir.7b01642
https://doi.org/10.1021/acs.langmuir.7b01642
Autor:
François-Xavier Cantrelle, Xavier Hanoulle, Ralf Bartenschlager, Marie Dujardin, Guy Lippens, Vanesa Madan, Isabelle Huvent, Hélène Launay, Neha S. Gandhi
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, 2019, 294 (35), pp.13171-13185. ⟨10.1074/jbc.RA119.009537⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, 294 (35), pp.13171-13185. ⟨10.1074/jbc.RA119.009537⟩
J Biol Chem
Journal of Biological Chemistry, 2019, 294 (35), pp.13171-13185. ⟨10.1074/jbc.RA119.009537⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, 294 (35), pp.13171-13185. ⟨10.1074/jbc.RA119.009537⟩
J Biol Chem
International audience; Implicated in numerous human diseases, intrinsically disordered proteins (IDPs) are dynamic ensembles of interconverting conformers that often contain many proline residues. Whether and how proline conformation regulates the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a3919ac688f598e1879a01b7a0b54d
https://hal.science/hal-02998113/file/Dujardin_Hanoulle_JBC_NS5A_diagonal_2019.pdf
https://hal.science/hal-02998113/file/Dujardin_Hanoulle_JBC_NS5A_diagonal_2019.pdf
Autor:
Irina Vetter, Jennifer R. Deuis, Sónia Troeira Henriques, Christina I. Schroeder, Marco Inserra, Zoltan Dekan, David J. Craik, Tzong-Hsien Lee, Richard J. Lewis, Paul F. Alewood, Mehdi Mobli, Marie-Isabel Aguilar
Publikováno v:
Journal of Biological Chemistry
Free to read at publisher's site. The μO-conotoxins MrVIA, MrVIB, and MfVIA inhibit the voltage-gated sodium channel NaV1.8, a well described target for the treatment of pain; however, little is known about the residues or structural elements that d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b3f96b520d204d4b6c4a845490818b
https://doi.org/10.1074/jbc.m116.721662
https://doi.org/10.1074/jbc.m116.721662
Autor:
Anne C. Conibear, David J. Craik, Gordon J. King, Sónia Troeira Henriques, Conan K. Wang, Mariana C. Ramos, Stephanie Chaousis
Publikováno v:
Journal of the American Chemical Society
Enantiomeric forms of BTD-2, PG-1, and PM-1 were synthesized to delineate the structure and function of these β-sheet antimicrobial peptides. Activity and lipid-binding assays confirm that these peptides act via a receptor-independent mechanism invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732484279d48341b6ead16a99ada56f3
https://doi.org/10.1021/jacs.6b02575
https://doi.org/10.1021/jacs.6b02575
Autor:
Alan E. Mark, Sónia Troeira Henriques, Christina I. Schroeder, Jennifer J. Smith, David J. Craik, Evelyne Deplazes, Glenn F. King
Publikováno v:
Biochimica et Biophysica Acta (BBA)-Biomembranes
Free to read at publisher's site. Many venom peptides are potent and selective inhibitors of voltage-gated ion channels, including channels that are validated therapeutic targets for treatment of a wide range of human diseases. However, the developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0877f4af06f02e7092f8b50768b12f4e
https://doi.org/10.1016/j.bbamem.2016.02.002
https://doi.org/10.1016/j.bbamem.2016.02.002