Zobrazeno 1 - 10
of 45
pro vyhledávání: '"030403 Characterisation of Biological Macromolecules"'
Autor:
Bogdan Lev, Thi Hanh Nguyen Pham, Alvaro Garcia, Amy Gorman, Flemming Cornelius, Toby W. Allen, Dil Diaz, Khondker R. Hossain, Ronald J. Clarke
Publikováno v:
Garcia, A, Lev, B, Hossain, K R, Gorman, A, Diaz, D, Thi Hanh Nguyen Pham,, Cornelius, F, Allen, T W & Clarke, R J 2019, ' Cholesterol depletion inhibits Na+,K+-ATPase activity in a near-native membrane environment ', Journal of Biological Chemistry, vol. 294, no. 15, pp. 5956-5969 . https://doi.org/10.1074/jbc.RA118.006223
Cholesterol’s effects on Na+,K+-ATPase reconstituted in phospholipid vesicles have been extensively studied. However, previous studies have reported both cholesterol-mediated stimulation and inhibition of Na+,K+-ATPase activity. Here, using partial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baab50f2b762754056da98040a3da7e
https://doi.org/10.1074/jbc.ra118.006223
https://doi.org/10.1074/jbc.ra118.006223
Autor:
Haipei Zou, Ronald J. Clarke, Annabelle Buda, Alvaro Garcia, Khondker R. Hossain, Qikui Henry Xu
Publikováno v:
ACS Omega
ACS Omega, Vol 4, Iss 1, Pp 518-527 (2019)
ACS Omega, Vol 4, Iss 1, Pp 518-527 (2019)
© 2019 American Chemical Society. Conformational changes of membrane proteins are accompanied by deformation in the surrounding lipid bilayer. To gain insight into the energetics of membrane deformation, the phase behavior of dimyristoylphosphatidyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de20dfc7a31e344119e102e3db779431
https://doi.org/10.1021/acsomega.8b03102
https://doi.org/10.1021/acsomega.8b03102
Publikováno v:
Neuropharmacology
Spider peptide toxins have attracted attention because of their ability to target voltage-gated ion channels, which are involved in several pathologies including chronic pain and some cardiovascular conditions. A class of these peptides acts by modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1a966ba144df9580a2185878effda5
https://doi.org/10.1016/j.neuropharm.2017.04.004
https://doi.org/10.1016/j.neuropharm.2017.04.004
Autor:
David J. Craik, Alysha G. Elliott, Yen-Hua Huang, Nicole Lawrence, Mark E. Cooper, Aurélie H. Benfield, Stephanie Chaousis, Olivier Cheneval, Sónia Troeira Henriques, Lai Yue Chan, Angela M. Kavanagh, Anjaneya S. Ravipati
Publikováno v:
ACS Chemical Biology
Gomesin, a disulfide-rich antimicrobial peptide produced by the Brazilian spider Acanthoscurria gomesiana, has been shown to be potent against Gram-negative bacteria and to possess selective anticancer properties against melanoma cells. In a recent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7463082d30e58b13c9b13a56d706128b
https://doi.org/10.1021/acschembio.7b00459
https://doi.org/10.1021/acschembio.7b00459
Autor:
Charles G. Cranfield, Boris Martinac, Paul Duckworth, Bruce Cornell, Sónia Troeira Henriques, David J. Craik
Publikováno v:
Langmuir
© 2017 American Chemical Society. Cyclotides are cyclic disulfide-rich peptides that are chemically and thermally stable and possess pharmaceutical and insecticidal properties. The activities reported for cyclotides correlate with their ability to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea94e4bab1bd05f4672d33e1b3ce218
https://doi.org/10.1021/acs.langmuir.7b01642
https://doi.org/10.1021/acs.langmuir.7b01642
Autor:
Alvaro Garcia, Simon Pochinda, Paninnguaq Naja Elgaard-Jørgensen, Ronald J. Clarke, Himanshu Khandelia
Publikováno v:
Garcia, A, Pochinda, S, Elgaard-Jørgensen, P N, Khandelia, H & Clarke, R J 2019, ' Evidence for ATP Interaction with Phosphatidylcholine Bilayers ', Langmuir, vol. 35, no. 30, pp. 9944-9953 . https://doi.org/10.1021/acs.langmuir.9b01240
© 2019 American Chemical Society. ATP is a fundamental intracellular molecule and is thought to diffuse freely throughout the cytosol. Evidence obtained from nucleotide-sensing sarcolemmal ion channels and red blood cells, however, suggest that ATP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae1457c491fdee45cadf7ac961d424f
https://hdl.handle.net/2123/21054
https://hdl.handle.net/2123/21054
Autor:
Ronald J. Clarke, Khondker R. Hossain
© 2019, International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature. Protein structure and function are modulated via interactions with their environment, representing both the surrounding aq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08952bf223330195764dbd9c63a09e5
https://europepmc.org/articles/PMC6557964/
https://europepmc.org/articles/PMC6557964/
Autor:
Hans-Jürgen Apell, Minwoo Han, Qiucen Jiang, Alvaro Garcia, Ronald J. Clarke, Himanshu Khandelia, Flemming Cornelius
Publikováno v:
Jiang, Q, Garcia, A, Han, M, Cornelius, F, Apell, H J, Khandelia, H & Clarke, R J 2017, ' Electrostatic Stabilization Plays a Central Role in Autoinhibitory Regulation of the Na +,K +-ATPase ', Biophysical Journal, vol. 112, no. 2, pp. 288-299 . https://doi.org/10.1016/j.bpj.2016.12.008
Jiang, Q, Garcia, A, Han, M, Cornelius, F, Apell, H-J, Khandelia, H & Clarke, R J 2017, ' Electrostatic Stabilization Plays a Central Role in Autoinhibitory Regulation of the Na+,K+-ATPase ', Biophysical Journal, vol. 112, no. 2, pp. 288-299 . https://doi.org/10.1016/j.bpj.2016.12.008
Jiang, Q, Garcia, A, Han, M, Cornelius, F, Apell, H-J, Khandelia, H & Clarke, R J 2017, ' Electrostatic Stabilization Plays a Central Role in Autoinhibitory Regulation of the Na+,K+-ATPase ', Biophysical Journal, vol. 112, no. 2, pp. 288-299 . https://doi.org/10.1016/j.bpj.2016.12.008
The Na+,K+-ATPase is present in the plasma membrane of all animal cells. It plays a crucial role in maintaining the Na+ and K+ electrochemical potential gradients across the membrane, which are essential in numerous physiological processes, e.g., ner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee9c8d156e4fa59b9da3015cb7f9e5c
https://doi.org/10.1016/j.bpj.2016.12.008
https://doi.org/10.1016/j.bpj.2016.12.008
Autor:
Alan E. Mark, Sónia Troeira Henriques, Christina I. Schroeder, Jennifer J. Smith, David J. Craik, Evelyne Deplazes, Glenn F. King
Publikováno v:
Biochimica et Biophysica Acta (BBA)-Biomembranes
Free to read at publisher's site. Many venom peptides are potent and selective inhibitors of voltage-gated ion channels, including channels that are validated therapeutic targets for treatment of a wide range of human diseases. However, the developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0877f4af06f02e7092f8b50768b12f4e
https://doi.org/10.1016/j.bbamem.2016.02.002
https://doi.org/10.1016/j.bbamem.2016.02.002
Publikováno v:
Current Opinion in Chemical Biology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e8497d22c4676e90cf90f318a1251a
https://doi.org/10.1016/j.cbpa.2017.05.012
https://doi.org/10.1016/j.cbpa.2017.05.012