Zobrazeno 1 - 10
of 6 591
pro vyhledávání: '"020602 bioinformatics"'
Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 19:2842-2850
Chromatin immunoprecipitation (ChIP-Seq) has emerged as a superior alternative to microarray technology as it provides higher resolution, less noise, greater coverage and wider dynamic range. While ChIP-Seq enables probing of DNA-protein interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038c0ea99fb7035da47fad0d2539a8f2
https://doi.org/10.1109/tcbb.2021.3104734
https://doi.org/10.1109/tcbb.2021.3104734
Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics
( Early Access ) Drug combination therapies have been a viable strategy for the treatment of complex diseases such as cancer due to increased efficacy and reduced side effects. However, experimentally validating all possible combinations for synergis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8a892a41ffbd2bdf1ccb729a497a93
https://doi.org/10.1109/tcbb.2021.3086702
https://doi.org/10.1109/tcbb.2021.3086702
Autor:
Qingfeng Chen, Jianxin Wang, Jin Liu, Ximin Wu, Dehuan Lai, Baoshan Chen, Wei Lan, Yi-Ping Phoebe Chen
Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 19:1715-1723
It has been proved that long noncoding RNA (lncRNA) plays critical roles in many human diseases. Therefore, inferring associations between lncRNAs and diseases can contribute to disease diagnosis, prognosis and treatment. To overcome the limitation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb11d81ab28f4c749c0c6c57cb092bd
https://doi.org/10.1109/tcbb.2020.3034910
https://doi.org/10.1109/tcbb.2020.3034910
Autor:
Fengpan Zhao, Pavel Skums, Yan Huang, Eric L. Sevigny, Alexander Zelikovsky, Yubao Wu, Monica H. Swahn, Sheryl Strasser
Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 19:180-191
The opioid abuse epidemic represents a major public health threat to global populations. The role social media may play in facilitating illicit drug trade is largely unknown due to limited research. However, it is known that social media use among ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93dac8b13928c3714bd755f748cb4a3a
https://doi.org/10.1109/tcbb.2020.2978476
https://doi.org/10.1109/tcbb.2020.2978476
Autor:
Devleena Ghosh, Chittaranjan Mandal
Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 19:343-354
An ordinary differential equation (ODE) model of the working of the thyroid system for euthyroidism has been presented. As clinical data for thyroid hormones is relatively scarce, such modelling offers potential benefits over wet lab procedures. Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656c4c1b53f48cb3dd50dab5b5258dd4
https://doi.org/10.1109/tcbb.2020.2995589
https://doi.org/10.1109/tcbb.2020.2995589
Autor:
Sanzo Miyazawa
Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 19:328-342
The inverse Potts problem to infer a Boltzmann distribution for homologous protein sequences from their single-site and pairwise amino acid frequencies recently attracts a great deal of attention in the studies of protein structure and evolution. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ed48c9f39aee5d78da0e580c269e3c
https://doi.org/10.1109/tcbb.2020.2993232
https://doi.org/10.1109/tcbb.2020.2993232
Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 19:168-179
A drug-drug interaction (DDI) is defined as an association between two drugs where the pharmacological effects of a drug are influenced by another drug. Positive DDIs can usually improve the therapeutic effects of patients, but negative DDIs cause th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2b799d67bd1d9fef46dff611225c0c
https://doi.org/10.1109/tcbb.2020.2988018
https://doi.org/10.1109/tcbb.2020.2988018
Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 19:383-394
Non-small cell lung cancer with an activating epidermal growth factor receptor (EGFR) mutation responds well to targeted drugs. In most cases, drug resistance appears after about a year. Several studies have been conducted on the kinase domain of EGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d585c7ff209732e1ecfad86b0eacc8
https://doi.org/10.1109/tcbb.2020.2995569
https://doi.org/10.1109/tcbb.2020.2995569
Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 19:614-623
Highly portable Oxford Nanopore sequencer producing long reads in real-time at low cost has made many breakthroughs in genomics studies. However, a major limitation of nanopore sequencing is its high errors when deciphering DNA sequences from noisy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4605faec2675f17750b571bb1694b83
https://doi.org/10.1109/tcbb.2020.3039244
https://doi.org/10.1109/tcbb.2020.3039244
Publikováno v:
Journal of Intelligent & Fuzzy Systems. 42:87-96
The use of fuzzy logic in machine learning is becoming widespread. In machine learning problems, the data, which have different characteristics, are trained and predicted together. Training the model consisting of data with different characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5c4187c1506982e5c9bb960c0fc6cd2
https://doi.org/10.3233/jifs-219177
https://doi.org/10.3233/jifs-219177