Zobrazeno 1 - 10
of 60
pro vyhledávání: '"0000-0001-5597-8127"'
Autor:
Oroz, Paula, Navo, Claudio D., Avenoza, Alberto, Busto, Jesús H., Corzana, Francisco, Jiménez-Osés, Gonzalo, Peregrina, Jesús M., 0000-0003-0161-412X, 0000-0003-4403-4790, 0000-0001-5597-8127, 0000-0003-0105-4337, 0000-0003-3778-7065
Publikováno v:
The Journal of Organic Chemistry. 87:14308-14318
Chemo- and diastereoselective 1,4-conjugate additions of anionic and radical
Autor:
Sousa, Bárbara B., de Almeida, Cátia Rebelo, Barahona, Ana F., Lopes, Raquel, Martins-Logrado, Ana, Cavaco, Marco, Neves, Vera, Carvalho, Luís A.R., Labaõ-Almeida, Carlos, Coelho, Ana R., Bento, Marta Leal, Lopes, Ricardo M.R.M., Oliveira, Bruno L., Castanho, Miguel A.R.B., Neumeister, Peter, Deutsch, Alexander, Vladimer, Gregory I., Krall, Nikolaus, Joaõ, Cristina, Corzana, Francisco, Seixas, Joaõ D., Fior, Rita, Bernardes, Gonçalo J.L., 0000-0002-0938-9038, 0000-0002-2989-7208, 0000-0001-7891-7562, 0000-0003-4205-7585, 0000-0001-5597-8127, 0000-0001-6594-8917
Bruton's tyrosine kinase (BTK) is a member of the TEC-family kinases and crucial for the proliferation and differentiation of B-cells. We evaluated the therapeutic potential of a covalent inhibitor (JS25) with nanomolar potency against BTK and with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe3f9b0697dca6740a74f3e7bf89647
https://www.repository.cam.ac.uk/handle/1810/343251
https://www.repository.cam.ac.uk/handle/1810/343251
Autor:
Ferhati, Xhenti, Jiménez-Moreno, Ester, Hoyt, Emily A., Salluce, Giulia, Cabeza-Cabrerizo, Mar, Navo, Claudio D., Compañón, Ismael, Akkapeddi, Padma, Matos, Maria J., Salaverri, Noelia, Garrido, Pablo, Martínez, Alfredo, Laserna, Víctor, Murray, Thomas V., Jiménez-Osés, Gonzalo, Ravn, Peter, Bernardes, Gonçalo J. L., Corzana, Francisco, 0000-0002-5045-433X, 0000-0001-6940-8803, 0000-0002-1615-6822, 0000-0003-0161-412X, 0000-0002-3470-8299, 0000-0002-5960-8569, 0000-0003-4882-4044, 0000-0003-0105-4337, 0000-0001-6594-8917, 0000-0001-5597-8127
Publikováno v:
RIUR. Repositorio Institucional de la Universidad de La Rioja
instname
instname
Copyright © 2022 The Authors. Published by American Chemical Society
Antibody-drug conjugates (ADCs) are a class of targeted therapeutics used to selectively kill cancer cells. It is important that they remain intact in the bloodstream and rele
Antibody-drug conjugates (ADCs) are a class of targeted therapeutics used to selectively kill cancer cells. It is important that they remain intact in the bloodstream and rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602082ac290726aecf4a1ef02e832266
Autor:
Díaz-Casado, Laura, Santana, Andrés G., Gómez-Pinto, Irene, Villacampa, Alejandro, Corzana, Francisco, Jiménez-Barbero, Jesús, González, Carlos, Asensio, Juan Luis, 0000-0003-0333-8624, 0000-0003-3568-7714, 0000-0001-7514-9991, 0000-0001-5597-8127, 0000-0001-5421-8513, 0000-0001-8796-1282, 0000-0001-7536-5221
Publikováno v:
Communications Chemistry. 5
10 pags., 8 figs.
NMR methods, and in particular ligand-based approaches, are among the most robust and reliable alternatives for binding detection and consequently, they have become highly popular in the context of hit identification and drug d
NMR methods, and in particular ligand-based approaches, are among the most robust and reliable alternatives for binding detection and consequently, they have become highly popular in the context of hit identification and drug d
Autor:
Istrate, Alena, Geeson, Michael B., Navo, Claudio D., Sousa, Barbara B., Marques, Marta C., Taylor, Ross J., Journeaux, Toby, Oehler, Sebastian R., Mortensen, Michael R., Deery, Michael J., Bond, Andrew D., Corzana, Francisco, Jiménez-Osés, Gonzalo, Bernardes, Gonçalo J. L., 0000-0002-9228-7947, 0000-0003-0161-412X, 0000-0003-4561-1828, 0000-0002-1744-0489, 0000-0001-5597-8127, 0000-0003-0105-4337, 0000-0001-6594-8917
Publikováno v:
RIUR. Repositorio Institucional de la Universidad de La Rioja
instname
Journal of the American Chemical Society, 144 (23)
instname
Journal of the American Chemical Society, 144 (23)
Protein conjugates are valuable tools for studying biological processes or producing therapeutics, such as antibody-drug conjugates. Despite the development of several protein conjugation strategies in recent years, the ability to modify one specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa740cfe85dd76a13a1f924d2b40d43
https://investigacion.unirioja.es/documentos/62c9e7a6a405bc00e417fb39
https://investigacion.unirioja.es/documentos/62c9e7a6a405bc00e417fb39
Autor:
Francesconi, Oscar, Corzana, Francisco, Kontogianni, Georgia-Ioanna, Pesciullesi, Giorgio, Gualdani, Roberta, Supuran, Claudiu T., Angeli, Andrea, Kavasi, Rafaela Maria, Chatzinikolaidou, Maria, Nativi, Cristina, 0000-0002-6155-4926, 0000-0001-5597-8127, 0000-0003-3617-4953, 0000-0003-4262-0323, 0000-0002-1470-7192, 0000-0002-6312-3230
Publikováno v:
ACS Pharmacology and Translational Science, Vol. 5, no. 11, p. 1119-1127 (2022)
Osteosarcoma is a heterogeneous tumor intimately linked to its microenvironment, which promotes its growth and spread. It is generally accompanied by cancer-induced bone pain (CIBP), whose main component is neuropathic pain. The TRPA1 ion channel pla
Autor:
Taleb, Víctor, Liao, Qinghua, Narimatsu, Yoshiki, García-García, Ana, Compañón, Ismael, Borges, Rafael Junqueira, González-Ramírez, Andrés Manuel, Corzana, Francisco, Clausen, Henrik, Rovira, Carme, Hurtado-Guerrero, Ramon, 0000-0003-1428-5695, 0000-0003-3791-2997, 0000-0001-6049-8806, 0000-0002-5838-0857, 0000-0001-5597-8127, 0000-0002-0915-5055, 0000-0003-1477-5010, 0000-0002-3122-9401
Publikováno v:
RIUR. Repositorio Institucional de la Universidad de La Rioja
instname
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Taleb, V, Liao, Q, Narimatsu, Y, García-García, A, Compañón, I, Borges, R J, González-Ramírez, A M, Corzana, F, Clausen, H, Rovira, C & Hurtado-Guerrero, R 2022, ' Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut ', Nature Communications, vol. 13, no. 1, 4324 . https://doi.org/10.1038/s41467-022-32021-9
instname
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Taleb, V, Liao, Q, Narimatsu, Y, García-García, A, Compañón, I, Borges, R J, González-Ramírez, A M, Corzana, F, Clausen, H, Rovira, C & Hurtado-Guerrero, R 2022, ' Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut ', Nature Communications, vol. 13, no. 1, 4324 . https://doi.org/10.1038/s41467-022-32021-9
Mucinases of human gut bacteria cleave peptide bonds in mucins strictly depending on the presence of neighboring O-glycans. The Akkermansia muciniphila AM0627 mucinase cleaves specifically in between contiguous (bis) O-glycans of defined truncated st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4e0539b8ea6dc97c6efec179f956a2
https://investigacion.unirioja.es/documentos/62f80c9f9162cc4ea7f1fcb9
https://investigacion.unirioja.es/documentos/62f80c9f9162cc4ea7f1fcb9
Autor:
González-Ramírez, Andrés Manuel, Grosso, Ana Sofia, Yang, Zhang, Compañón, Ismael, Coelho, Helena, Narimatsu, Yoshiki, Clausen, Henrik, Marcelo, Filipa, Corzana, Francisco, Hurtado-Guerrero, Ramon, 0000-0002-5838-0857, 0000-0002-4756-5813, 0000-0003-1428-5695, 0000-0002-0915-5055, 0000-0001-5597-8127, 0000-0002-3122-9401
Publikováno v:
RIUR. Repositorio Institucional de la Universidad de La Rioja
instname
Zaguán. Repositorio Digital de la Universidad de Zaragoza
González-Ramírez, A M, Grosso, A S, Yang, Z, Compañón, I, Coelho, H, Narimatsu, Y, Clausen, H, Marcelo, F, Corzana, F & Hurtado-Guerrero, R 2022, ' Structural basis for the synthesis of the core 1 structure by C1GalT1 ', Nature Communications, vol. 13, no. 1, 2398 . https://doi.org/10.1038/s41467-022-29833-0
instname
Zaguán. Repositorio Digital de la Universidad de Zaragoza
González-Ramírez, A M, Grosso, A S, Yang, Z, Compañón, I, Coelho, H, Narimatsu, Y, Clausen, H, Marcelo, F, Corzana, F & Hurtado-Guerrero, R 2022, ' Structural basis for the synthesis of the core 1 structure by C1GalT1 ', Nature Communications, vol. 13, no. 1, 2398 . https://doi.org/10.1038/s41467-022-29833-0
LA/P/0140/2020 MX20229-11 BFU2016-75633-P PID2019-105451GB-I00 RTI2018-099592-B-C21 E34_R17 LMP58_18 DNRF107 LA/P/0140/2020 2020.00233.CEECIND 2020.03261.CEECIND ROTEIRO/0031/2013–PINFRA/22161/2016 N°283570 BIOSTRUCTX_5186). Publisher Copyright:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0a22fe46c5990d3b306b6ba2e334a3
https://investigacion.unirioja.es/documentos/628009a43333e458234bb7e1
https://investigacion.unirioja.es/documentos/628009a43333e458234bb7e1
Autor:
Calabrese, Camilla, Uriarte, Iciar, Insausti, Aran, Vallejo-López, Montserrat, Basterretxea, Francisco J., Cochrane, Stephen A., Davis, Benjamin G., Corzana, Francisco, Cocinero, Emilio J., 0000-0003-4299-2098, 0000-0002-6239-6915, 0000-0002-5056-407X, 0000-0001-5597-8127, 0000-0001-7632-3728
Publikováno v:
Calabrese, C, Uriarte, I, Vallejo-Lopez, M, Basterretxea, F, Cochrane, S, Davis, B, Corzana, F & Cocinero, E J 2020, ' Observation of the Unbiased Conformers of Putative DNA-Scaffold Ribosugars ', ACS Central Science, vol. 6, no. 2, pp. 293-303 . https://doi.org/10.1021/acscentsci.9b01277
RIUR. Repositorio Institucional de la Universidad de La Rioja
instname
ACS Central Science
ACS Central Science, Vol 6, Iss 2, Pp 293-303 (2020)
RIUR. Repositorio Institucional de la Universidad de La Rioja
instname
ACS Central Science
ACS Central Science, Vol 6, Iss 2, Pp 293-303 (2020)
The constitution, configuration, and flexibility of the core sugars of DNA molecules alter their function in diverse roles. Conformational itineraries of the ribofuranosides (fs) have long been known to finely determine rates of processing, yet we al
Autor:
García-García, Ana, Ceballos-Laita, Laura, Serna, Sonia, Artschwager, Raik, Reichardt, Niels C., Corzana, Francisco, Hurtado-Guerrero, Ramon, 0000-0002-7223-1719, 0000-0001-5597-8127, 0000-0002-3122-9401
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
RIUR. Repositorio Institucional de la Universidad de La Rioja
instname
Nature Communications
García-García, A, Ceballos-Laita, L, Serna, S, Artschwager, R, Reichardt, N C, Corzana, F & Hurtado-Guerrero, R 2020, ' Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase ', Nature Communications, vol. 11, no. 1, 973 . https://doi.org/10.1038/s41467-020-14794-z
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Consejo Superior de Investigaciones Científicas (CSIC)
RIUR. Repositorio Institucional de la Universidad de La Rioja
instname
Nature Communications
García-García, A, Ceballos-Laita, L, Serna, S, Artschwager, R, Reichardt, N C, Corzana, F & Hurtado-Guerrero, R 2020, ' Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase ', Nature Communications, vol. 11, no. 1, 973 . https://doi.org/10.1038/s41467-020-14794-z
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Consejo Superior de Investigaciones Científicas (CSIC)
Core-fucosylation is an essential biological modification by which a fucose is transferred from GDP-β-L-fucose to the innermost N-acetylglucosamine residue of N-linked glycans. A single human enzyme α1,6-fucosyltransferase (FUT8) is the only enzyme