Zobrazeno 1 - 10
of 21
pro vyhledávání: '"‡ Marie-Hélène Fouchet"'
Autor:
Stéphane Sautet, Emilie Jigorel, Nicolas Faucher, Jamel Meslamani, Lara Kathryn Leister, Pascal Grondin, Julie A. Cox, Bryan W. King, Pamela Nassau, Gemma Victoria White, Brad J. Geddes, Alain Claude-Marie Daugan, Helen H. Sun, Michael T. Ouellette, Pauline Lamoureux, Elizabeth J. Rivera, Scott B. Berger, James H. Thorpe, Philip A. Harris, J. Mosley, Susan E. Hutchinson, Frédéric Donche, John Bertin, Sandra J. Hoffman, Natalie Wellaway, Patrick M. Eidam, Paris Ward, Florent Potvain, Clark A. Sehon, Sebastien Andre Campos, Robert W. Marquis, Peter J. Gough, Mukesh K. Mahajan, Veronique Beneton, Jae U. Jeong, Michelle C. Schaeffer, John D. Lich, Allison M. Beal, Rakesh Nagilla, James Michael Woolven, Bonnie L. Hoffman, Anderson Niall Andrew, Marie-Hélène Fouchet, Deepak Bandyopadhyay, Carol A. Capriotti, Rachel D. Totoritis, Joshua N. Finger, Kishore K. Pasikanti, David D. Wisnoski, Sze-Ling Ng, Nino Campobasso, Nicolas George, Michael Reilly
Publikováno v:
Journal of Medicinal Chemistry. 62:5096-5110
RIP1 kinase regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including inflammatory and neurological diseases. Currently, RIP1 kinase inhibitors have advanced into early clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ff65b82b2e1feff6acc28b9dcac4dc
https://doi.org/10.1021/acs.jmedchem.9b00318
https://doi.org/10.1021/acs.jmedchem.9b00318
Autor:
Andrew C. Pearce, Alexis Denis, Ann Louise Walker, Pam Nassau, Emma V. Edgar, Anne Marie Jeanne Bouillot, Lionel Trottet, Yichen Wang, Alain Hovnanian, Oxana Polyakova, Marie-Hélène Fouchet, Alexandre Moquette, Duncan S. Holmes, Alan R. Ferrie, Alain Laroze, Kathrine J. Smith, John Liddle, Ryan P. Bingham, Pamela Thomas, James H. Thorpe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:126771
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b1a57828183ae24040336d881d16820
https://doi.org/10.1016/j.bmcl.2019.126771
https://doi.org/10.1016/j.bmcl.2019.126771
Autor:
Julien Sançon, Veronique Beneton, Paul Martres, Edwige Nicodeme, Nicolas Ancellin, Nicolas Faucher, Jean-Jacques Tousaint, Yannick Saintillan, Yann Lamotte, Stéphane Sautet, Didier Grillot, Marie-Hélène Fouchet, Olivier Pineau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1098-1103
Identification of indazole derivatives acting as dual angiotensin II type 1 (AT1) receptor antagonists and partial peroxisome proliferator-activated receptor-γ (PPARγ) agonists is described. Starting from Telmisartan, we previously described that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7734bd05776715f9fce40d12fc7a62
https://doi.org/10.1016/j.bmcl.2014.01.004
https://doi.org/10.1016/j.bmcl.2014.01.004
Autor:
Pam Nassau, Andrew C. Pearce, Lionel Trottet, Ann Louise Walker, Alexis Denis, Duncan S. Holmes, Pamela Thomas, Alan R. Ferrie, Kathrine J. Smith, Alexandre Moquette, James H. Thorpe, Emma V. Edgar, Anne Marie Jeanne Bouillot, Marie-Hélène Fouchet, Alain Laroze, John Liddle, Ryan P. Bingham, Alain Hovnanian, Oxana Polyakova, Yichen Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:126675
The connection between Netherton syndrome and overactivation of epidermal/dermal proteases, particularly Kallikrein 5 (KLK5) has been well established and it is expected that a KLK5 inhibitor would improve the dermal barrier and also reduce the pain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f23e1bc1a3359bd89418e4e0a463a7
https://doi.org/10.1016/j.bmcl.2019.126675
https://doi.org/10.1016/j.bmcl.2019.126675
Autor:
Hervé Coste, Marie-Hélène Fouchet, Frédéric Donche, Sylvie Demaria Magny, Florent Potvain, M Walker, Marc Issandou, Nerina Dodic, Anne-Benedicte Boullay, Anne Marie Jeanne Bouillot, Christophe Junot, Christelle Martin
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6218-6232
We describe the discovery of novel potent inhibitors of 2,3-oxidosqualene:lanosterol cyclase inhibitors (OSCi) from a focused pharmacophore-based screen. Optimization of the most tractable hits gave a series of compounds showing inhibition of cholest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cc548326435712eff6b2fe670048ac
https://doi.org/10.1016/j.bmc.2008.04.034
https://doi.org/10.1016/j.bmc.2008.04.034
Autor:
‡ Marie-Hélène Fouchet, Valerie Boullay, Francoise Jeanne Gellibert, Anne-Charlotte De Gouville, Victoria Lucy Helen Lovegrove, Ward Smith, Stéphane Huet, C. A. Janson, Neil Mathews, Gael Krysa, ‡ Van-Loc Nguyen, Ruolan Wang, David Hartley, James Michael Woolven, Alain Laroze, Helen Susanne Goodland, Stéphane Sautet
Publikováno v:
Journal of Medicinal Chemistry. 47:4494-4506
Optimization of the screening hit 1 led to the identification of novel 1,5-naphthyridine aminothiazole and pyrazole derivatives, which are potent and selective inhibitors of the transforming growth factor-beta type I receptor, ALK5. Compounds 15 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5649bddf59110f498fc52810d4fce222
https://doi.org/10.1021/jm0400247
https://doi.org/10.1021/jm0400247
Autor:
Marc Le Bret, Corinne Gauthier, Jiří Kozelka, Karel Zimmermann, Eric Guittet, Marie-Hélène Fouchet, J.A.H. Cognet, Jean-Claude Chottard
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 2:83-92
The structure of the second major adduct formed by the antitumor drug cisplatin with DNA, the intrastand cis–Pt(NH3)2{d(ApG)N7–N7} chelate (A*G*), has been investigated using a double-stranded nonanucleotide, d(CTCA*G*CCTC)-d(GAGGCTGAG), by means
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8a897aa4a096faec9253691fd9d8531
https://doi.org/10.1007/s007750050109
https://doi.org/10.1007/s007750050109
Autor:
Michal Sabat, Jirí Kozelka, Marie-Hélène Fouchet, Bernhard Lippert, Guy Schröder, Rut Beyerle-Pfnür
Publikováno v:
Inorganic Chemistry. 35:1647-1652
A model compound of the second most abundant DNA adduct of the antitumor agent cisplatin has been synthesized and structurally and spectroscopically characterized and its conformational behavior examined: cis-[(NH3)2Pt(9-MeA-N7)(9-EtGH-N7)](NO3)2·2H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dc5031ddeda19fd315a02f145e544f2
https://doi.org/10.1021/ic950754s
https://doi.org/10.1021/ic950754s
Autor:
Marie-Hélène Fouchet, Patrick Gaillard, Dominique Meyer, Pierre-Alain Carrupt, Bernard Testa, Myriam Petta
Publikováno v:
Pharmaceutical Research. 12:1583-1591
Purpose. The regular distribution in space and the stability in time of the hydrophilic sphere surrounding iobitridol were investigated. This is a novel yet important concept in the design of polyiodinated contrast agents since such a sphere is meant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34dc7c5a628f5d983040843f669ae467
https://doi.org/10.1023/a:1016272412775
https://doi.org/10.1023/a:1016272412775
Publikováno v:
Journal of Inorganic Biochemistry. 53:261-271
Platinum coordination to the N7 atom of a purine nucleotide generally shifts the H8 and H2 resonances downfield. This downfield shift originates from the “inductive effect,” i.e., the effect of diminishing the electron density on the H8 or H2 ato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31a3ac27572a43e05533fa340534d5c3
https://doi.org/10.1016/0162-0134(94)85113-1
https://doi.org/10.1016/0162-0134(94)85113-1