Zobrazeno 1 - 10
of 31
pro vyhledávání: '"‡ Jean-Michel Luccarini"'
Autor:
Leticia Laura Niborski, Paul Gueguen, Mengliang Ye, Allan Thiolat, Rodrigo Nalio Ramos, Pamela Caudana, Jordan Denizeau, Ludovic Colombeau, Raphaël Rodriguez, Christel Goudot, Jean-Michel Luccarini, Anne Soudé, Bruno Bournique, Pierre Broqua, Luigia Pace, Sylvain Baulande, Christine Sedlik, Jean-Pierre Quivy, Geneviève Almouzni, José L. Cohen, Elina Zueva, Joshua J. Waterfall, Sebastian Amigorena, Eliane Piaggio
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Abstract Tumor-infiltrating CD8 + T cells progressively lose functionality and fail to reject tumors. The underlying mechanism and re-programing induced by checkpoint blockers are incompletely understood. We show here that genetic ablation or pharmac
Externí odkaz:
https://doaj.org/article/22bfa2b345944a4983ce8b49f08339e4
Autor:
Leticia Laura Niborski, Paul Gueguen, Mengliang Ye, Allan Thiolat, Rodrigo Nalio Ramos, Pamela Caudana, Jordan Denizeau, Ludovic Colombeau, Raphaël Rodriguez, Christel Goudot, Jean-Michel Luccarini, Anne Soudé, Bruno Bournique, Pierre Broqua, Luigia Pace, Sylvain Baulande, Christine Sedlik, Jean-Pierre Quivy, Geneviève Almouzni, José L. Cohen, Elina Zueva, Joshua J. Waterfall, Sebastian Amigorena, Eliane Piaggio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/103f997df819424ea57c7cf97b5024dc
Autor:
Eugeni Entchev, Ingrid Jantzen, Philippe Masson, Stephanie Bocart, Bruno Bournique, Jean-Michel Luccarini, Andre Bouchot, Olivier Lacombe, Jean-Louis Junien, Pierre Broqua, Mireille Tallandier
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233032 (2020)
Mucopolysaccharidoses are a class of lysosomal storage diseases, characterized by enzymatic deficiency in the degradation of specific glycosaminoglycans (GAG). Pathological accumulation of excess GAG leads to multiple clinical symptoms with systemic
Externí odkaz:
https://doaj.org/article/18aaeaa92fd84ae2983028dab3ec1275
Autor:
Bruno Bournique, Eugeni Entchev, Stephanie Bocart, Ingrid Jantzen, Jean-Louis Junien, Jean-Michel Luccarini, Olivier Lacombe, Philippe Masson, Mireille Tallandier, Pierre Broqua, André Bouchot
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2020, 15 (5), pp.e0233032. ⟨10.1371/journal.pone.0233032⟩
PLoS ONE, Vol 15, Iss 5, p e0233032 (2020)
PLoS ONE, 2020, 15 (5), pp.e0233032. ⟨10.1371/journal.pone.0233032⟩
PLoS ONE, Public Library of Science, 2020, 15 (5), pp.e0233032. ⟨10.1371/journal.pone.0233032⟩
PLoS ONE, Vol 15, Iss 5, p e0233032 (2020)
PLoS ONE, 2020, 15 (5), pp.e0233032. ⟨10.1371/journal.pone.0233032⟩
International audience; Mucopolysaccharidoses are a class of lysosomal storage diseases, characterized by enzymatic deficiency in the degradation of specific glycosaminoglycans (GAG). Pathological accumulation of excess GAG leads to multiple clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57cf8f55479c409e7f909dd02436ef8
https://www.hal.inserm.fr/inserm-02894692
https://www.hal.inserm.fr/inserm-02894692
Autor:
Jean-Michel Luccarini, Christophe Guignabert, Irena Konstantinova, Sonia Pezet, Jérémy Sadoine, Jean-Louis Junien, Pierre Broqua, Yannick Allanore, Anne Cauvet, Thomas Guilbert, Ly Tu, Jérôme Avouac
Publikováno v:
Annals of the Rheumatic Diseases. 76:1931-1940
ObjectiveTo evaluate the antifibrotic effects of the pan-peroxisome proliferator-activated receptor (PPAR) agonist IVA337 in preclinical mouse models of pulmonary fibrosis and related pulmonary hypertension (PH).MethodsIVA337 has been evaluated in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa63a66592a1f101e0abc351675cb4a9
https://doi.org/10.1136/annrheumdis-2016-210821
https://doi.org/10.1136/annrheumdis-2016-210821
Autor:
Guillaume Wettstein, Jean-Michel Luccarini, Laurence Poekes, Patrick Faye, Ingrid Jantzen, Evelyne Defrêne, Irena Konstantinova, Francine Kupkowski, Sven Francque, Isabelle Leclercq, Alain Philippot, Pascale Tuyaa‐Boustugue, Vanessa Adarbes, Julien Tessier, Dereck A. Mann, Xavier Gawronski, Pierre Broqua, Fiona Oakley, Jean-Louis Junien, Céline Estivalet
Publikováno v:
Hepatology Communications
IVA337 is a pan-peroxisome proliferator-activated receptor (PPAR) agonist with moderate and well-balanced activity on the three PPAR isoforms (α, γ, δ). PPARs are regulators of lipid metabolism, inflammation, insulin resistance, and fibrogenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d57e1bb7cc8792647ba67870166e86
https://doi.org/10.1002/hep4.1057
https://doi.org/10.1002/hep4.1057
Autor:
Richard McCarthy, Rebecca M. Edelmayer, Maria A. Argiriadi, Didier Bressac, Craig Wallace, Michael E. Kort, Yibing Wang, Laura Leys, Eric C. Breinlinger, J. Wetter, Zhi Su, Jean-Michel Luccarini, P. Honore, K. Salte, Philippe Masson, Christian Goess, Stephen B. Gauld, Kevin P. Cusack, Donna Gauvin, S. Huang, Dominique Potin, Sébastien Jacquet, S. McGaraughty, Kelly E. Desino
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 371(1)
Blockade of interleukin (IL)-23 or IL-17 with biologics is clinically validated as a treatment of psoriasis. However, the clinical impact of targeting other nodes within the IL-23/IL-17 pathway, especially with small molecules, is less defined. We re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034e971e80621670c1cc818c78451615
https://pubmed.ncbi.nlm.nih.gov/31375639
https://pubmed.ncbi.nlm.nih.gov/31375639
Autor:
Sonia Pezet, Thomas Guilbert, Nadira Ruzehaji, Yannick Allanore, Matthieu Ponsoye, Jean-Louis Junien, Jérôme Avouac, Pierre Broqua, Jean-Michel Luccarini, Camelia Frantz
Publikováno v:
Annals of the Rheumatic Diseases
Background The pathogenesis of systemic sclerosis (SSc) involves a distinctive triad of autoimmune, vascular and inflammatory alterations resulting in fibrosis. Evidence suggests that peroxisome proliferator-activated receptors (PPARs) play an import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e97c8b03f49e0f243a19c8aa8664e66
https://doi.org/10.1136/annrheumdis-2015-208029
https://doi.org/10.1136/annrheumdis-2015-208029
Autor:
Irena Konstantinova, Marie Dorchie, Christelle Valaire, Aude Boulay, Didier Jean, Pascale Tuya-Boustugue, Jean-Louis Junien, Robin Tranchand, Anne Soude, Florence Chirade, Céline Estivalet, Lisa Quetel, Jean-Michel Luccarini, Martine Barth, Pierre Broqua, Jean-Baptiste Assié, Geneviève Cheret, Séverine Delaporte
Publikováno v:
Molecular Cancer Research. 18:B14-B14
We have recently reported the development of YAP-TEAD interaction inhibitors that disrupt the YAP-TEAD complex and block proliferation of tumor cells. These compounds represent promising new treatment modalities for mesothelioma where the Hippo pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e6197646dcafbf0238f68e6baa8e4ff
https://doi.org/10.1158/1557-3125.hippo19-b14
https://doi.org/10.1158/1557-3125.hippo19-b14
Autor:
Jérémy Sadoine, Jean-Louis Junien, G Thomas, Pierre Broqua, Irena Konstantinova, Jérôme Avouac, Sonia Pezet, Christophe Guignabert, Jean-Michel Luccarini, Yannick Allanore, A. Cauvet, Ly Tu
Publikováno v:
Oral Presentations.
Background Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors known to modulate fibrosis. The pan-PPAR agonist IVA337 recently demonstrated efficacy in prevention and treatment of experimental skin fibrosis (1). Objectives Our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::905e630db91110a69d9a1b9e55626ef2
https://doi.org/10.1136/annrheumdis-2017-eular.3805
https://doi.org/10.1136/annrheumdis-2017-eular.3805