Výsledky vyhledávání - "† J.-L. Aubagnac"

O–N-Acyl migration in N-terminal serine-containing peptides: mass spectrometric elucidation and subsequent development of site-directed acylation protocols

Autor: J.-L. Aubagnac, Gilles Subra, Laetitia Mouls, Jean Martinez, Christine Enjalbal

Publikováno v: Tetrahedron Letters. 45:1173-1178

The synthesis of a modified pentapeptide involving the palmitoylation of the hydroxyl group of a serine residue present at the N-terminal position is presented. An O–N-acyl shift was observed by LC/MS/MS, the two isobaric molecules exhibiting upon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ece690f73fdf6babb7a21578af9325a
https://doi.org/10.1016/j.tetlet.2003.12.008

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Characterization of Soluble Polymer Supported Organic Compounds by LC/Electrospray Ionization MS Toward a Complete Automation of the Liquid-Phase Process in Combinatorial Chemistry

Autor: R. Lazaro, Frédéric Lamaty, Neerja Yadav-Bhatnagar, and J. Martinez, S. Varray, † J.-L. Aubagnac, P. Sanchez, P. Ribière, E. Suberchicot, Christine Enjalbal

Publikováno v: Analytical Chemistry. 75:175-184

In the case of a soluble polymer supported synthesis, the tuning of the support solubility depending on the solvent offers new opportunities for combinatorial chemistry for two reasons. First, organic syntheses in solution are generally easily transl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570c15867668267f318bf4d6ed1528f8
https://doi.org/10.1021/ac0203701

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Time-of-flight secondary ion mass spectrometry of Fmoc-amino acids linked to solid supports through ionic interactions

Autor: Jean Martinez, Christine Enjalbal, J.-L. Aubagnac, Robert Combarieu, Gilles Subra

Publikováno v: Rapid Communications in Mass Spectrometry. 12:1715-1720

The TOF-SIMS (time-of-flight- secondary ion mass spectrometry) spectra of Fmoc-amino acids linked to solid supports through ionic interactions have been studied to examine if easy desorption of preformed ions from the surface occurred. Preliminary re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3ae9140c22fdd60b65c36a8362eb97a
https://doi.org/10.1002/(sici)1097-0231(19981130)12:22<1715::aid-rcm397>3.0.co

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Tof-SIMS Analysis of Polymer Bound Fmoc-protected Peptides

Autor: Robert Combarieu, Christine Enjalbal, Jean Martinez, J.-L. Aubagnac, C. Drouot, Pierre Fulcrand, Y. de Puydt

Publikováno v: Tetrahedron Letters. 38:2455-2458

We report the results obtained in the step by step control of a solid phase peptide synthesis carried out on Sheppard polyamide resin by Time of flight - Secondary Ion Mass Spectrometry. © 1997 Published by Elsevier Science Ltd.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7484f935341eef77b12d83c96e723f2a
https://doi.org/10.1016/s0040-4039(97)00367-5

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Step-by-step Control by Time-of-flight Secondary Ion Mass Spectrometry of a Peptide Synthesis Carried Out on Polymer Beads

Autor: Jean Martinez, J.-L. Aubagnac, Christine Enjalbal, Robert Combarieu, C. Drouot, Pierre Fulcrand, Y. de Puydt

Publikováno v: Rapid Communications in Mass Spectrometry. 10:1509-1511

The use of time-of-flight secondary ion mass spectrometry (Tof-SIMS) for the step-by-step control of a peptide synthesis on a solid support is illustrated. The positive secondary ions, issuing from energetic fragmentation, are characteristic of the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::499f7081380302359f1b1b6767e867c7
https://doi.org/10.1002/(sici)1097-0231(199609)10:12<1509::aid-rcm663>3.0.co

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Imaging polymer supported organic molecules by mass spectrometry Application in combinatorial chemistry

Autor: José Luis Martínez, Christine Enjalbal, Robert Combarieu, D. Maux, J.-L. Aubagnac

Publikováno v: Scopus-Elsevier

In combinatorial chemistry, most libraries are prepared according to solid-phase synthesis strategies using resins or pins. Although synthesis and purification steps are facilitated, reaction monitoring presents difficulties. Since the polymeric supp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd3876942b65503625deb1674583e91
https://doi.org/10.1557/proc-804-jj10.2

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Quantitative determination of rocuronium in human plasma by liquid chromatography-electrospray ionization mass spectrometry

Autor: J.-L. Aubagnac, C Farenc, Michel Audran, Jean Martinez, Christine Enjalbal, Françoise Bressolle, Pierre Sanchez

Publikováno v: Journal of chromatography. A. 910(1)

Liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) was used for the quantification of the neuromuscular blocking agent rocuronium in human plasma. Verapamil was used as internal standard. The samples were subjected to a dichl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad469bc439a107506dc6390821220d1
https://pubmed.ncbi.nlm.nih.gov/11263576

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