Zobrazeno 1 - 10
of 2 671
pro vyhledávání: '"κ opioid receptor"'
Publikováno v:
BMC Plant Biology, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Diviner’s sage (Salvia divinorum; Lamiaceae) is the source of the powerful hallucinogen salvinorin A (SalA). This neoclerodane diterpenoid is an agonist of the human Κ-opioid receptor with potential medical applications in the
Externí odkaz:
https://doaj.org/article/acef4c1fb64d41e6b9f03b7720e66129
Autor:
Yoshihisa UENOYAMA, Miku NONOGAKI, Hitomi TSUCHIDA, Marina TAKIZAWA, Sena MATSUZAKI, Naoko INOUE, Hiroko TSUKAMURA
Publikováno v:
The Journal of Reproduction and Development, Vol 70, Iss 5, Pp 327-337 (2024)
In mammals, secretion of tonic (pulsatile) gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) is often suppressed during lactation. Suppression of GnRH/LH pulses in lactating dams is assumed to be caused by suckling stimuli and a chronic
Externí odkaz:
https://doaj.org/article/1de02d5e56d340ed8d509f7bff937d8b
Publikováno v:
PeerJ, Vol 12, p e17333 (2024)
Acute heart attack is the primary cause of cardiovascular-related death worldwide. A common treatment is reperfusion of ischemic tissue, which can cause irreversible damage to the myocardium. The number of mitochondria in cardiomyocytes is large, whi
Externí odkaz:
https://doaj.org/article/07c4bc17b7034aafbd3c3648e9cb861c
Autor:
Shi Yi, Tao Huaqiang, Li Xueyan, Zhang Liyuan, Li Chunhui, Sun Wen, Chu Miao, Chen Kai, Zhu Pengfei, Wang Qiang, Gu Chengyong, Wang Liangliang, Yang Xing, Hao Yuefeng
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 82-95 (2023)
Osteoarthritis (OA) is a prevalent and chronic joint disease that affects the aging population, causing pain and disability. Macrophages in synovium are important mediators of synovial inflammatory activity and pathological joint pain. Previous studi
Externí odkaz:
https://doaj.org/article/611fa88370a240b8b72466cf09e91e77
Autor:
Mingming Pan, Guihua Wang, Li Zhou, Yan Xu, Li Yao, Chaoqing Wu, Changlin Mei, Zhanzheng Zhao, Dong Sun, Tianjun Guan, Qinkai Chen, Ming Shi, Hui Xu, Weifang Zeng, Fangqiong Li, Rui Yan, Bi-Cheng Liu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: HSK21542, a novel selective peripherally-restricted κ-opioid receptor agonist has been proven to be a safe and effective analgesic and antipruritic drug in both in vitro and in vivo studies. We aimed to evaluate its safety, pharmacokinet
Externí odkaz:
https://doaj.org/article/6ffce28274cf400f8494918263c44e91
Akademický článek
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Autor:
Christos Karoussiotis, Aggeliki Sotiriou, Alexia Polissidis, Alexandra Symeonof, Danae Papavranoussi-Daponte, Vassiliki Nikoletopoulou, Zafiroula Georgoussi
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Recent evidence has shown that G protein-coupled receptors (GPCRs) are direct sensors of the autophagic machinery and opioid receptors regulate neuronal plasticity and neurotransmission with an as yet unclarified mechanism. Using in vitro and in vivo
Externí odkaz:
https://doaj.org/article/b851696575124806880da1cfeb859931
Akademický článek
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Autor:
Steven Fishbane, Warren Wen, Catherine Munera, Rong Lin, Sukirti Bagal, Kieran McCafferty, Frédérique Menzaghi, Joana Goncalves
Publikováno v:
Kidney Medicine, Vol 4, Iss 8, Pp 100513- (2022)
Rationale & Objective: We report a pooled safety analysis of intravenous difelikefalin in participants with moderate to severe chronic kidney disease–associated pruritus (CKD-aP) treated by hemodialysis in 4 phase 3 clinical studies. Study Design:
Externí odkaz:
https://doaj.org/article/8d26c49df96b4c5b9ae526ccb4ca3b96
Autor:
Joel Topf, Thomas Wooldridge, Kieran McCafferty, Michael Schömig, Botond Csiky, Rafal Zwiech, Warren Wen, Sarbani Bhaduri, Catherine Munera, Rong Lin, Alia Jebara, Joshua Cirulli, Frédérique Menzaghi
Publikováno v:
Kidney Medicine, Vol 4, Iss 8, Pp 100512- (2022)
Rationale & Objective: Chronic kidney disease–associated pruritus (CKD-aP) in patients treated by hemodialysis (HD) impairs quality of life (QoL). Difelikefalin, a selective κ-opioid receptor agonist, decreased the intensity of CKD-aP in patients
Externí odkaz:
https://doaj.org/article/5fb7b3df14f54a62a57229d07fedc475