Zobrazeno 1 - 10
of 191
pro vyhledávání: '"γ-secretase inhibitors"'
Autor:
Marta Weinstock
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Alzheimer’s disease (AD) is the most common form of dementia. Mutations in genes and precursors of β amyloid (Aβ) are found in the familial form of the disease. This led to the evaluation of seven monoclonal antibodies against Aβ in subjects wit
Externí odkaz:
https://doaj.org/article/fe27bf7088a74360a4db3ce26714976e
Autor:
Zheng, Chuanxi a, Huang, Jianghong b, Xu, Gang a, Li, Wei a, Weng, Xin c, Zhang, Shiquan a, ⁎
Publikováno v:
In BBA - Molecular Basis of Disease January 2024 1870(1)
Autor:
Jiaxuan Li, Xin Wu, Xin Tan, Shixin Wang, Ruisi Qu, Xiaofeng Wu, Zhouqing Chen, Zhong Wang, Gang Chen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
BackgroundThis meta-analysis evaluates the efficacy and safety of amyloid-β (Aβ) targeted therapies for delaying cognitive deterioration in Alzheimer’s disease (AD).MethodsPubMed, EMBASE, the Cochrane Library, and ClinicalTrials.gov were systemat
Externí odkaz:
https://doaj.org/article/b614396effef43078df3520f6bb820c4
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/0f77c0081f1d42b49febc63bcef80bd8
Publikováno v:
Experimental Hematology & Oncology, Vol 9, Iss 1, Pp 1-9 (2020)
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is one of the hematological malignancies. With the applications of chemotherapy regimens and allogeneic hematopoietic stem cell transplantation, the cure rate of T-ALL has been significantly improv
Externí odkaz:
https://doaj.org/article/766f020f66c14c478143d39920198f4d
Autor:
Zhongbo Du, Luo Li, Wei Sun, Pingyu Zhu, Shulin Cheng, Xuesong Yang, Chunli Luo, Xiaodong Yu, Xiaohou Wu
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The treatment of castration-resistant prostate cancer (CRPC) remains challenging due to the failure of androgen deprivation therapy (ADT); hence the search for other molecular therapeutic targets besides androgen receptor signaling is ongoing. This s
Externí odkaz:
https://doaj.org/article/3809515b097e45259b90213bdd524baf
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Alzheimer’s disease (AD) is the most common type of senile dementia, characterized by neurofibrillary tangle and amyloid plaque in brain pathology. Major efforts in AD drug were devoted to the interference with the production and accumulation of am
Externí odkaz:
https://doaj.org/article/dda4eee2bf234c228a47b10bc249e7bc
Autor:
Shinji Tagami, Kanta Yanagida, Takashi S. Kodama, Mako Takami, Naoki Mizuta, Hiroshi Oyama, Kouhei Nishitomi, Yu-wen Chiu, Toru Okamoto, Takeshi Ikeuchi, Gaku Sakaguchi, Takashi Kudo, Yoshiharu Matsuura, Akio Fukumori, Masatoshi Takeda, Yasuo Ihara, Masayasu Okochi
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 259-273 (2017)
γ-secretase inhibitors (GSI) are drugs developed to decrease amyloid-β peptide (Aβ) production by inhibiting intramembranous cleavage of β-amyloid protein precursor (βAPP). However, a large phase 3 trial of semagacestat, a potential non-transiti
Externí odkaz:
https://doaj.org/article/e0c2b7842afc48ba9915c840c0c2dbd5
Autor:
Yong Ran, Fokhrul Hossain, Antonio Pannuti, Christian B Lessard, Gabriela Z Ladd, Joo In Jung, Lisa M Minter, Barbara A Osborne, Lucio Miele, Todd E Golde
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 7, Pp 950-966 (2017)
Abstract γ‐Secretase inhibitors (GSIs) are being actively repurposed as cancer therapeutics based on the premise that inhibition of NOTCH1 signaling in select cancers is therapeutic. Using novel assays to probe effects of GSIs against a broader pa
Externí odkaz:
https://doaj.org/article/3fbd1320bd9d4856944b5a4a455c213b
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